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• W1541620413 abstract "The metabolic inter-relationships between malarial parasites and their host erythrocytes are poorly understood. They have been investigated hitherto mostly by observing parasite behavior in erythrocyte variants, in metabolically altered erythrocytes, or in cell-free in vitro systems. We have studied the interconnection between the bioenergetic metabolism of host and parasite through compartment analysis of ATP in Plasmodium falciparum-infected human red blood cells, using Sendai virus-induced host cell lysis. ATP concentrations in host and parasite compartments were found to be equal. Inhibitors of mitochondrial activity reduce ATP levels to a similar extent in host and parasite compartments, although only the parasite contains functional mitochondria. It is shown that equalization of ATP levels is brought about by means of an adenylate translocator, probably localized at the parasite plasma membrane, in conjunction with adenylate kinase activity detected both in host and parasite compartments. The translocator is inhibited by compounds which are known to inhibit specifically the translocator of the inner membrane of mammalian mitochondria, with identical inhibitory constants. Addition of these inhibitors to intact infected cells causes a rapid depletion of ATP in the host compartment and a parallel increase in the parasite, suggesting that the parasite supplies ATP to its host cell rather than the reverse." @default.
• W1541620413 created "2016-06-24" @default.
• W1541620413 creator A5006955278 @default.
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• W1541620413 date "1989-02-01" @default.
• W1541620413 modified "2023-10-16" @default.
• W1541620413 title "Metabolic Interconnection between the Human Malarial Parasite Plasmodium falciparum and Its Host Erythrocyte" @default.
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• W1541620413 doi "https://doi.org/10.1016/s0021-9258(18)94050-0" @default.
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