FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1541722522> ?p ?o ?g. }

• W1541722522 endingPage "54" @default.
• W1541722522 startingPage "247" @default.
• W1541722522 abstract "To investigate the signal transduction mechanisms involved in the cell death of human retinal pigment epithelial (RPE) cells after their exposure to either hydrogen peroxide (H(2)O(2)) or tri-butyl hydroxperoxide (tBH).Cultured human RPE (hRPE) cells were treated with the chemical oxidants tBH and H(2)O(2) as well as with the synthetic ceramide analogs C(2), C(6), and dihydroceramide for different time periods. Apoptosis was determined by TUNEL staining and annexin-V labeling of phosphatidylserine exposure. Ceramide levels were quantified by the diacylglycerol kinase assay using thin-layer chromatography.H(2)O(2) and tBH caused a high level of apoptosis in the hRPE cells. At the same time, both of these oxidants induced an early and late increase in the intracellular production of ceramide, a lipid second messenger. Moreover, addition of C(2) and C(6) synthetic ceramides caused a high level of apoptosis in these hRPE cells. In contrast, treatment with the immediate precursor of ceramide, dihydroceramide, resulted in no apoptotic response.The results demonstrate that H(2)O(2) and tBH induce apoptosis in hRPE cells and suggest that the underlying signaling mechanism involves ceramide generation." @default.
• W1541722522 created "2016-06-24" @default.
• W1541722522 creator A5005902735 @default.
• W1541722522 creator A5029053264 @default.
• W1541722522 creator A5045074249 @default.
• W1541722522 date "2001-01-01" @default.
• W1541722522 modified "2023-10-03" @default.
• W1541722522 title "Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells." @default.
• W1541722522 cites W113490788 @default.
• W1541722522 cites W1446970532 @default.
• W1541722522 cites W1503456481 @default.
• W1541722522 cites W1522283730 @default.
• W1541722522 cites W1523528479 @default.
• W1541722522 cites W1536956900 @default.
• W1541722522 cites W1590434810 @default.
• W1541722522 cites W1607687470 @default.
• W1541722522 cites W166477924 @default.
• W1541722522 cites W169563596 @default.
• W1541722522 cites W1879184430 @default.
• W1541722522 cites W19113225 @default.
• W1541722522 cites W1969158591 @default.
• W1541722522 cites W1970054633 @default.
• W1541722522 cites W1971335269 @default.
• W1541722522 cites W1972331889 @default.
• W1541722522 cites W1981883990 @default.
• W1541722522 cites W1984373476 @default.
• W1541722522 cites W1991865867 @default.
• W1541722522 cites W2000823512 @default.
• W1541722522 cites W2007604755 @default.
• W1541722522 cites W2015899487 @default.
• W1541722522 cites W2017729786 @default.
• W1541722522 cites W2026993099 @default.
• W1541722522 cites W2027127436 @default.
• W1541722522 cites W2036566995 @default.
• W1541722522 cites W2036951674 @default.
• W1541722522 cites W2038882649 @default.
• W1541722522 cites W2047393488 @default.
• W1541722522 cites W2049108649 @default.
• W1541722522 cites W2053858732 @default.
• W1541722522 cites W2056217426 @default.
• W1541722522 cites W2075338210 @default.
• W1541722522 cites W2083545792 @default.
• W1541722522 cites W2083549154 @default.
• W1541722522 cites W2089346216 @default.
• W1541722522 cites W2090663997 @default.
• W1541722522 cites W2112694631 @default.
• W1541722522 cites W2118385360 @default.
• W1541722522 cites W2126544407 @default.
• W1541722522 cites W2135687585 @default.
• W1541722522 cites W2159453240 @default.
• W1541722522 cites W2161990266 @default.
• W1541722522 cites W2280929046 @default.
• W1541722522 cites W2292538025 @default.
• W1541722522 cites W2396031219 @default.
• W1541722522 cites W1988212470 @default.
• W1541722522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11133876" @default.
• W1541722522 hasPublicationYear "2001" @default.
• W1541722522 type Work @default.
• W1541722522 sameAs 1541722522 @default.
• W1541722522 citedByCount "26" @default.
• W1541722522 countsByYear W15417225222015 @default.
• W1541722522 countsByYear W15417225222019 @default.
• W1541722522 countsByYear W15417225222020 @default.
• W1541722522 countsByYear W15417225222021 @default.
• W1541722522 countsByYear W15417225222022 @default.
• W1541722522 countsByYear W15417225222023 @default.
• W1541722522 crossrefType "journal-article" @default.
• W1541722522 hasAuthorship W1541722522A5005902735 @default.
• W1541722522 hasAuthorship W1541722522A5029053264 @default.
• W1541722522 hasAuthorship W1541722522A5045074249 @default.
• W1541722522 hasConcept C153911025 @default.
• W1541722522 hasConcept C163235415 @default.
• W1541722522 hasConcept C170493617 @default.
• W1541722522 hasConcept C180899940 @default.
• W1541722522 hasConcept C181199279 @default.
• W1541722522 hasConcept C185592680 @default.
• W1541722522 hasConcept C190283241 @default.
• W1541722522 hasConcept C195794163 @default.
• W1541722522 hasConcept C196795494 @default.
• W1541722522 hasConcept C2777851122 @default.
• W1541722522 hasConcept C2778024200 @default.
• W1541722522 hasConcept C2778703144 @default.
• W1541722522 hasConcept C2778918659 @default.
• W1541722522 hasConcept C2779637612 @default.
• W1541722522 hasConcept C2780827179 @default.
• W1541722522 hasConcept C36020004 @default.
• W1541722522 hasConcept C41625074 @default.
• W1541722522 hasConcept C55493867 @default.
• W1541722522 hasConcept C61322309 @default.
• W1541722522 hasConcept C62478195 @default.
• W1541722522 hasConcept C79879829 @default.
• W1541722522 hasConcept C86803240 @default.
• W1541722522 hasConcept C88634738 @default.
• W1541722522 hasConcept C95444343 @default.
• W1541722522 hasConceptScore W1541722522C153911025 @default.
• W1541722522 hasConceptScore W1541722522C163235415 @default.
• W1541722522 hasConceptScore W1541722522C170493617 @default.
• W1541722522 hasConceptScore W1541722522C180899940 @default.

• next