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- W1541891857 abstract "Introduction: Infants with critical congenital heart disease exhibit a high prevalence of hypoxic-ischemic white matter injury (WMI). Infants with transposition of the great arteries (TGA) have a greater risk for pre-operative injury, whereas infants with hypoplastic left heart syndrome (HLHS) have post-operative injury. Recent work has shown that increasing time from birth to surgery increases these risks for WMI in both cohorts. Understanding the changing preoperative cerebral physiology will help shed light on the differences in the timing of injury between diagnoses. Methods: Term neonates with TGA or HLHS were recruited. Frequency domain diffuse optical spectroscopy and diffuse correlation spectroscopy were employed to noninvasively quantify cerebral oxygen saturation (ScO2) and cerebral blood flow (CBF) prior to surgery. Cerebral oxygen extraction fraction (OEF) was calculated from ScO2 and arterial oxygen saturation from arterial blood gases. Subjects were grouped by time-to-surgery, with one group..." @default.
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- W1541891857 date "2014-11-25" @default.
- W1541891857 modified "2023-09-23" @default.
- W1541891857 title "Abstract 19783: Cerebral Oxygenation on Morning of Surgery Dependent on Time-to-Surgery in Infants with Critical Congenital Heart Disease" @default.
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