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• W1541926685 endingPage "1691" @default.
• W1541926685 startingPage "1685" @default.
• W1541926685 abstract "Abstract Background and Aim We have reported previously that RNA interference targeting stathmin1 (STMN1) gene in human gastric cancer cells inhibits proliferation in vitro and tumor growth in vivo . Based on these observations, in the present study, the possibility that local injection of lentivirus‐delivered stathmin sh RNA would induce regression of the established human gastric cancer xenograft in animal model was investigated. Methods BALB /c nude mice were inoculated subcutaneously into the right armpit with human gastric cancer cells SGC ‐7901 (2 × 10 6 cells in 200 μL phosphate‐buffered saline) to develop a xenograft model of human gastric cancer . When tumor reached suitable size, mice were randomly divided into two groups. STMN 1 shRNA group ( n = 6) were given local injection of lentivirus‐delivered STMN 1 shRNA , and the non‐silencing shRNA group ( n = 6) were administered with local injection of lentivirus‐delivered non‐silencing shRNA . Quantitative reverse transcription–polymerase chain reaction and Western blot were used to verify the knockdown of the gene expression in dissected tumor at m RNA and protein level, respectively. Results Experimental therapy on the nude mice model bearing subcutaneous tumor of SGC ‐7901 cells showed that local administration of STMN 1 shRNA effectively regressed the pre‐established tumors. Stathmin shRNA ‐treated tumors were significantly regressed as compared with that of the tumor injected with non‐silencing shRNA ( P < 0.05). Tumor weight was significantly decreased in STMN 1‐treated group as compared with non‐silencing shRNA group ( P < 0.05). Quantitative reverse transcription–polymerase chain reaction and Western blot showed downregulation of STMN 1 gene expression in STMN 1 shRNA group as compared with non‐silencing shRNA group ( P < 0.05). Conclusion These findings highlight the potential use of local injection of lentivirus‐delivered shRNA for the treatment of early localized human gastric carcinoma." @default.
• W1541926685 created "2016-06-24" @default.
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• W1541926685 date "2014-08-25" @default.
• W1541926685 modified "2023-10-03" @default.
• W1541926685 title "Effectiveness of local injection of lentivirus-delivered stathmin1 and stathmin1 shRNA in human gastric cancer xenograft mouse" @default.
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• W1541926685 doi "https://doi.org/10.1111/jgh.12594" @default.
• W1541926685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24720379" @default.
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