Matches in SemOpenAlex for { <https://semopenalex.org/work/W1541948668> ?p ?o ?g. }
- W1541948668 endingPage "1152" @default.
- W1541948668 startingPage "1145" @default.
- W1541948668 abstract "Summary: Purpose: The imbalance between neuronal inhibition and excitation contributes to epileptogenesis. Inhibition in the central nervous system (CNS) is mediated by γ‐aminobutyric acid (GABA) and glycine. Recent studies indicate the expression of glycine receptor (GlyR) in hippocampus and neocortex. However, the function of GlyR in these regions is not clarified completely. The aim of this study was to investigate whether the GlyR agonists glycine and taurine promote an anticonvulsive effect. Methods: We induced epileptiform discharges by reducing extracellular Mg 2+ concentration in combined rat entorhinal cortex–hippocampal slices (400 μm). Epileptiform discharges were detected by using extracellular recording techniques. Results: Seizure‐like events were suppressed by taurine, exhibiting a half‐maximal inhibitory effect (IC 50 ) of 0.9 m M . Suppression of late recurrent discharges in the medial entorhinal cortex and recurrent short discharges in the hippocampus was obtained at an IC 50 value of 1.6 and 2.1 m M , respectively. Strychnine at concentrations <1 μ M abolished these effects. Likewise glycine, after an initial proconvulsant effect, suppressed epileptiform discharges. Conclusions: These findings show that GlyR agonists, in particular taurine, could serve as potential anticonvulsants and suggest an important role of GlyR in cortical function and dysfunction." @default.
- W1541948668 created "2016-06-24" @default.
- W1541948668 creator A5012579071 @default.
- W1541948668 creator A5030931801 @default.
- W1541948668 creator A5038636074 @default.
- W1541948668 creator A5076655042 @default.
- W1541948668 creator A5091270897 @default.
- W1541948668 date "2003-08-12" @default.
- W1541948668 modified "2023-10-14" @default.
- W1541948668 title "Effects of Taurine and Glycine on Epileptiform Activity Induced by Removal of Mg2+ in Combined Rat Entorhinal Cortex-Hippocampal Slices" @default.
- W1541948668 cites W1509513803 @default.
- W1541948668 cites W1599587228 @default.
- W1541948668 cites W1628508588 @default.
- W1541948668 cites W1828807460 @default.
- W1541948668 cites W1965572139 @default.
- W1541948668 cites W1969090298 @default.
- W1541948668 cites W1985931825 @default.
- W1541948668 cites W1986416004 @default.
- W1541948668 cites W1993673975 @default.
- W1541948668 cites W1994466328 @default.
- W1541948668 cites W2002976069 @default.
- W1541948668 cites W2004554357 @default.
- W1541948668 cites W2012958850 @default.
- W1541948668 cites W2018241752 @default.
- W1541948668 cites W2023457194 @default.
- W1541948668 cites W2023478773 @default.
- W1541948668 cites W2040742860 @default.
- W1541948668 cites W2043863538 @default.
- W1541948668 cites W2044300873 @default.
- W1541948668 cites W2055690117 @default.
- W1541948668 cites W2081246829 @default.
- W1541948668 cites W2081678712 @default.
- W1541948668 cites W2095881782 @default.
- W1541948668 cites W2108308578 @default.
- W1541948668 cites W2149991357 @default.
- W1541948668 cites W2191585768 @default.
- W1541948668 cites W2413277475 @default.
- W1541948668 cites W2435599913 @default.
- W1541948668 cites W277323024 @default.
- W1541948668 cites W279177745 @default.
- W1541948668 cites W69531756 @default.
- W1541948668 doi "https://doi.org/10.1046/j.1528-1157.2003.01603.x" @default.
- W1541948668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12919385" @default.
- W1541948668 hasPublicationYear "2003" @default.
- W1541948668 type Work @default.
- W1541948668 sameAs 1541948668 @default.
- W1541948668 citedByCount "65" @default.
- W1541948668 countsByYear W15419486682012 @default.
- W1541948668 countsByYear W15419486682013 @default.
- W1541948668 countsByYear W15419486682014 @default.
- W1541948668 countsByYear W15419486682015 @default.
- W1541948668 countsByYear W15419486682016 @default.
- W1541948668 countsByYear W15419486682017 @default.
- W1541948668 countsByYear W15419486682018 @default.
- W1541948668 countsByYear W15419486682019 @default.
- W1541948668 countsByYear W15419486682021 @default.
- W1541948668 countsByYear W15419486682022 @default.
- W1541948668 crossrefType "journal-article" @default.
- W1541948668 hasAuthorship W1541948668A5012579071 @default.
- W1541948668 hasAuthorship W1541948668A5030931801 @default.
- W1541948668 hasAuthorship W1541948668A5038636074 @default.
- W1541948668 hasAuthorship W1541948668A5076655042 @default.
- W1541948668 hasAuthorship W1541948668A5091270897 @default.
- W1541948668 hasBestOaLocation W15419486681 @default.
- W1541948668 hasConcept C148762608 @default.
- W1541948668 hasConcept C169760540 @default.
- W1541948668 hasConcept C17077164 @default.
- W1541948668 hasConcept C185592680 @default.
- W1541948668 hasConcept C2777222312 @default.
- W1541948668 hasConcept C2777725853 @default.
- W1541948668 hasConcept C2777756961 @default.
- W1541948668 hasConcept C2779701627 @default.
- W1541948668 hasConcept C2780715579 @default.
- W1541948668 hasConcept C2781161787 @default.
- W1541948668 hasConcept C28406088 @default.
- W1541948668 hasConcept C35599011 @default.
- W1541948668 hasConcept C515207424 @default.
- W1541948668 hasConcept C55493867 @default.
- W1541948668 hasConcept C57236427 @default.
- W1541948668 hasConcept C86803240 @default.
- W1541948668 hasConceptScore W1541948668C148762608 @default.
- W1541948668 hasConceptScore W1541948668C169760540 @default.
- W1541948668 hasConceptScore W1541948668C17077164 @default.
- W1541948668 hasConceptScore W1541948668C185592680 @default.
- W1541948668 hasConceptScore W1541948668C2777222312 @default.
- W1541948668 hasConceptScore W1541948668C2777725853 @default.
- W1541948668 hasConceptScore W1541948668C2777756961 @default.
- W1541948668 hasConceptScore W1541948668C2779701627 @default.
- W1541948668 hasConceptScore W1541948668C2780715579 @default.
- W1541948668 hasConceptScore W1541948668C2781161787 @default.
- W1541948668 hasConceptScore W1541948668C28406088 @default.
- W1541948668 hasConceptScore W1541948668C35599011 @default.
- W1541948668 hasConceptScore W1541948668C515207424 @default.
- W1541948668 hasConceptScore W1541948668C55493867 @default.
- W1541948668 hasConceptScore W1541948668C57236427 @default.
- W1541948668 hasConceptScore W1541948668C86803240 @default.
- W1541948668 hasIssue "9" @default.
- W1541948668 hasLocation W15419486681 @default.