FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1541972404> ?p ?o ?g. }

• W1541972404 endingPage "1017" @default.
• W1541972404 startingPage "1006" @default.
• W1541972404 abstract "The Galphaq protein-coupled metabotropic glutamate receptor subtype-5 (mGluR5) is densely expressed in medium spiny projection neurons of striatum. Emerging evidence suggests a significant role of mGluR5 in the addictive plasticity of striatal neurons that is likely derived from inducible cellular gene expression related to stimulation of mGluR5 and associative signaling proteins. In this study, we found that activation of mGluR5 with a selective agonist (RS)-2-chloro-5-hydroxy-phenylglycine (CHPG) induced a rapid and transient phosphorylation of a transcription regulator Elk-1 in cultured striatal neurons from rat E19 embryos or neonatal day-1 pups. The Elk-1 phosphorylation was dose-dependent and occurred in neurochemically identified GABAergic neurons, but not glia. A series of experiments further demonstrated that the CHPG-stimulated Elk-1 phosphorylation was mediated through selective activation of mGluR5-regulated phospholipase C and associative second messenger system, i.e. 1,4,5,-triphosphate-sensitive Ca2+ release. Moreover, the Elk-1 phosphorylation was partially dependent on mGluR5-mediated co-activation of NMDA, but not kainate/AMPA receptors and L-type voltage-operated Ca2+ channels. Using an immediate early gene c-fos as a report of inducible gene expression, we found that CHPG induced marked c-fos mRNA expression. The c-fos induction kinetically corresponded to the Elk-1 phosphorylation and was attenuated by antisense oligonucleotides that selectively knocked down Elk-1 proteins. These results indicate that glutamatergic tone on mGluR5 is positively coupled to Elk-1 phosphorylation in striatal neurons via multiple signaling mechanisms involving Ca2+ release and NMDA activation, and the mGluR5-mediated Elk-1 phosphorylation facilitates gene transcription." @default.
• W1541972404 created "2016-06-24" @default.
• W1541972404 creator A5049821571 @default.
• W1541972404 creator A5069926062 @default.
• W1541972404 date "2003-04-23" @default.
• W1541972404 modified "2023-10-16" @default.
• W1541972404 title "Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons" @default.
• W1541972404 cites W1485811943 @default.
• W1541972404 cites W1494401713 @default.
• W1541972404 cites W1526274619 @default.
• W1541972404 cites W1584917605 @default.
• W1541972404 cites W1606273823 @default.
• W1541972404 cites W1656928430 @default.
• W1541972404 cites W1674210262 @default.
• W1541972404 cites W1784311570 @default.
• W1541972404 cites W1902968354 @default.
• W1541972404 cites W1908744325 @default.
• W1541972404 cites W1919086687 @default.
• W1541972404 cites W1964327045 @default.
• W1541972404 cites W1965435203 @default.
• W1541972404 cites W1965828206 @default.
• W1541972404 cites W1969499006 @default.
• W1541972404 cites W1972174862 @default.
• W1541972404 cites W1980166477 @default.
• W1541972404 cites W1991262933 @default.
• W1541972404 cites W1999157780 @default.
• W1541972404 cites W2000595326 @default.
• W1541972404 cites W2001232602 @default.
• W1541972404 cites W2003472138 @default.
• W1541972404 cites W2006703412 @default.
• W1541972404 cites W2012959255 @default.
• W1541972404 cites W2022446197 @default.
• W1541972404 cites W2030668938 @default.
• W1541972404 cites W2034998738 @default.
• W1541972404 cites W2038884731 @default.
• W1541972404 cites W2039524747 @default.
• W1541972404 cites W2041894539 @default.
• W1541972404 cites W2042007534 @default.
• W1541972404 cites W2050153206 @default.
• W1541972404 cites W2051628416 @default.
• W1541972404 cites W2057234179 @default.
• W1541972404 cites W2062464911 @default.
• W1541972404 cites W2069504977 @default.
• W1541972404 cites W2073632705 @default.
• W1541972404 cites W2089271111 @default.
• W1541972404 cites W2089913300 @default.
• W1541972404 cites W2092511667 @default.
• W1541972404 cites W2094993760 @default.
• W1541972404 cites W2101024344 @default.
• W1541972404 cites W2106042714 @default.
• W1541972404 cites W2108415605 @default.
• W1541972404 cites W2115120555 @default.
• W1541972404 cites W2130227962 @default.
• W1541972404 cites W2138435646 @default.
• W1541972404 cites W2151473045 @default.
• W1541972404 cites W2157450061 @default.
• W1541972404 cites W2157630627 @default.
• W1541972404 cites W2163302723 @default.
• W1541972404 cites W2170571477 @default.
• W1541972404 cites W2233543443 @default.
• W1541972404 cites W2330457575 @default.
• W1541972404 cites W2501810239 @default.
• W1541972404 doi "https://doi.org/10.1046/j.1471-4159.2003.01750.x" @default.
• W1541972404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12716432" @default.
• W1541972404 hasPublicationYear "2003" @default.
• W1541972404 type Work @default.
• W1541972404 sameAs 1541972404 @default.
• W1541972404 citedByCount "22" @default.
• W1541972404 countsByYear W15419724042012 @default.
• W1541972404 countsByYear W15419724042018 @default.
• W1541972404 countsByYear W15419724042019 @default.
• W1541972404 countsByYear W15419724042020 @default.
• W1541972404 countsByYear W15419724042021 @default.
• W1541972404 crossrefType "journal-article" @default.
• W1541972404 hasAuthorship W1541972404A5049821571 @default.
• W1541972404 hasAuthorship W1541972404A5069926062 @default.
• W1541972404 hasBestOaLocation W15419724041 @default.
• W1541972404 hasConcept C104317684 @default.
• W1541972404 hasConcept C11960822 @default.
• W1541972404 hasConcept C150194340 @default.
• W1541972404 hasConcept C160268369 @default.
• W1541972404 hasConcept C169760540 @default.
• W1541972404 hasConcept C170493617 @default.
• W1541972404 hasConcept C189184402 @default.
• W1541972404 hasConcept C26702167 @default.
• W1541972404 hasConcept C2779555244 @default.
• W1541972404 hasConcept C2780062018 @default.
• W1541972404 hasConcept C41653306 @default.
• W1541972404 hasConcept C49051014 @default.
• W1541972404 hasConcept C513476851 @default.
• W1541972404 hasConcept C55493867 @default.
• W1541972404 hasConcept C61174792 @default.
• W1541972404 hasConcept C67018056 @default.
• W1541972404 hasConcept C85714458 @default.
• W1541972404 hasConcept C86803240 @default.
• W1541972404 hasConcept C95444343 @default.
• W1541972404 hasConceptScore W1541972404C104317684 @default.
• W1541972404 hasConceptScore W1541972404C11960822 @default.

• next