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• W1542013166 abstract "A series of 17 analogs of 1-acetyl-4,5-dihydro(1H)pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1–7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure–activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H2DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect." @default.
• W1542013166 created "2016-06-24" @default.
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• W1542013166 date "2014-08-19" @default.
• W1542013166 modified "2023-09-23" @default.
• W1542013166 title "1-Acetyl-3,5-diaryl-4,5-dihydro(1<i>H</i>)pyrazoles: Exhibiting Anticancer Activity through Intracellular ROS Scavenging and the Mitochondria-Dependent Death Pathway" @default.
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• W1542013166 doi "https://doi.org/10.1002/ardp.201400199" @default.
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