FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542016002> ?p ?o ?g. }

• W1542016002 endingPage "3911" @default.
• W1542016002 startingPage "3903" @default.
• W1542016002 abstract "Research Article1 October 1993free access Multiple and cooperative phosphorylation events regulate the CREM activator function. R.P. de Groot R.P. de Groot Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J. den Hertog J. den Hertog Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J.R. Vandenheede J.R. Vandenheede Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J. Goris J. Goris Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author P. Sassone-Corsi P. Sassone-Corsi Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author R.P. de Groot R.P. de Groot Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J. den Hertog J. den Hertog Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J.R. Vandenheede J.R. Vandenheede Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author J. Goris J. Goris Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author P. Sassone-Corsi P. Sassone-Corsi Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. Search for more papers by this author Author Information R.P. Groot1, J. Hertog1, J.R. Vandenheede1, J. Goris1 and P. Sassone-Corsi1 1Laboratoire Génétique Moléculaire des Eucaryotes, CNRS, U184 de l'INSERM, Faculté de Médecine, Institut de Chimie Biologique, Strasbourg, France. The EMBO Journal (1993)12:3903-3911https://doi.org/10.1002/j.1460-2075.1993.tb06068.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Phosphorylation is one of the major mechanisms by which the activity of transcription factors can be regulated. We have investigated the role of phosphorylation in the regulation of the transcription factor CREM. We show that the CREM tau activator is phosphorylated on multiple serine and threonine residues in vivo. Stimulation of various signal transduction pathways by forskolin, TPA or Ca2+ ionophore leads to enhanced phosphorylation of serine 117, concomitant with an increase in the transactivation potential of CREM tau. We have identified multiple kinases that can also phosphorylate S117 in vitro. Moreover, we show that casein kinase I and II cooperatively phosphorylate CREM tau on multiple residues, eliciting enhanced DNA binding. Cooperative phosphorylation is also observed with other kinases. These results show that the activity of CREM tau is regulated by multiple phosphorylation events, suggesting that CREM could be considered as a nuclear effector where signalling pathways may converge and/or cross-talk. Previous ArticleNext Article Volume 12Issue 101 October 1993In this issue RelatedDetailsLoading ..." @default.
• W1542016002 created "2016-06-24" @default.
• W1542016002 creator A5001911257 @default.
• W1542016002 creator A5027622225 @default.
• W1542016002 creator A5034335838 @default.
• W1542016002 creator A5037786135 @default.
• W1542016002 creator A5056922106 @default.
• W1542016002 date "1993-10-01" @default.
• W1542016002 modified "2023-10-16" @default.
• W1542016002 title "Multiple and cooperative phosphorylation events regulate the CREM activator function." @default.
• W1542016002 cites W1484266107 @default.
• W1542016002 cites W1490733930 @default.
• W1542016002 cites W1528493806 @default.
• W1542016002 cites W1533422392 @default.
• W1542016002 cites W1534965462 @default.
• W1542016002 cites W1537623701 @default.
• W1542016002 cites W1562004079 @default.
• W1542016002 cites W1599831143 @default.
• W1542016002 cites W1850214287 @default.
• W1542016002 cites W1873199501 @default.
• W1542016002 cites W1887488204 @default.
• W1542016002 cites W1958327809 @default.
• W1542016002 cites W1973135307 @default.
• W1542016002 cites W1987519198 @default.
• W1542016002 cites W1996339709 @default.
• W1542016002 cites W1998861020 @default.
• W1542016002 cites W2000024512 @default.
• W1542016002 cites W2005150284 @default.
• W1542016002 cites W2005396212 @default.
• W1542016002 cites W2021334674 @default.
• W1542016002 cites W2025308343 @default.
• W1542016002 cites W2028242823 @default.
• W1542016002 cites W2034160157 @default.
• W1542016002 cites W2058332440 @default.
• W1542016002 cites W2066060074 @default.
• W1542016002 cites W2071140879 @default.
• W1542016002 cites W2076063939 @default.
• W1542016002 cites W2077088537 @default.
• W1542016002 cites W2077309544 @default.
• W1542016002 cites W2078962110 @default.
• W1542016002 cites W2081704409 @default.
• W1542016002 cites W2082797919 @default.
• W1542016002 cites W2088335423 @default.
• W1542016002 cites W2109399660 @default.
• W1542016002 cites W2126203912 @default.
• W1542016002 cites W2169844307 @default.
• W1542016002 cites W2209144728 @default.
• W1542016002 cites W2240996803 @default.
• W1542016002 cites W49383898 @default.
• W1542016002 cites W9258115 @default.
• W1542016002 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06068.x" @default.
• W1542016002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413673" @default.
• W1542016002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8404858" @default.
• W1542016002 hasPublicationYear "1993" @default.
• W1542016002 type Work @default.
• W1542016002 sameAs 1542016002 @default.
• W1542016002 citedByCount "187" @default.
• W1542016002 countsByYear W15420160022012 @default.
• W1542016002 countsByYear W15420160022013 @default.
• W1542016002 countsByYear W15420160022014 @default.
• W1542016002 countsByYear W15420160022016 @default.
• W1542016002 countsByYear W15420160022017 @default.
• W1542016002 countsByYear W15420160022018 @default.
• W1542016002 countsByYear W15420160022019 @default.
• W1542016002 countsByYear W15420160022021 @default.
• W1542016002 countsByYear W15420160022022 @default.
• W1542016002 crossrefType "journal-article" @default.
• W1542016002 hasAuthorship W1542016002A5001911257 @default.
• W1542016002 hasAuthorship W1542016002A5027622225 @default.
• W1542016002 hasAuthorship W1542016002A5034335838 @default.
• W1542016002 hasAuthorship W1542016002A5037786135 @default.
• W1542016002 hasAuthorship W1542016002A5056922106 @default.
• W1542016002 hasBestOaLocation W15420160021 @default.
• W1542016002 hasConcept C104317684 @default.
• W1542016002 hasConcept C121332964 @default.
• W1542016002 hasConcept C138885662 @default.
• W1542016002 hasConcept C153911025 @default.
• W1542016002 hasConcept C15708023 @default.
• W1542016002 hasConcept C55493867 @default.
• W1542016002 hasConcept C86803240 @default.
• W1542016002 hasConcept C88045685 @default.
• W1542016002 hasConceptScore W1542016002C104317684 @default.
• W1542016002 hasConceptScore W1542016002C121332964 @default.
• W1542016002 hasConceptScore W1542016002C138885662 @default.
• W1542016002 hasConceptScore W1542016002C153911025 @default.
• W1542016002 hasConceptScore W1542016002C15708023 @default.
• W1542016002 hasConceptScore W1542016002C55493867 @default.
• W1542016002 hasConceptScore W1542016002C86803240 @default.
• W1542016002 hasConceptScore W1542016002C88045685 @default.
• W1542016002 hasIssue "10" @default.
• W1542016002 hasLocation W15420160021 @default.
• W1542016002 hasLocation W15420160022 @default.
• W1542016002 hasLocation W15420160023 @default.
• W1542016002 hasOpenAccess W1542016002 @default.
• W1542016002 hasPrimaryLocation W15420160021 @default.
• W1542016002 hasRelatedWork W2271181815 @default.
• W1542016002 hasRelatedWork W2902782467 @default.
• W1542016002 hasRelatedWork W2935759653 @default.

• next