Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542215809> ?p ?o ?g. }
- W1542215809 endingPage "767" @default.
- W1542215809 startingPage "759" @default.
- W1542215809 abstract "Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid, nitrotyrosine in vulnerable neurons of patients with Alzheimer disease (AD). To determine whether oxidative damage is an early- or end-stage event in the process of neurodegeneration in AD, we investigated the relationship between neuronal 8OHG and nitrotyrosine and histological and clinical variables, i.e. amyloid-beta (A beta) plaques and neurofibrillary tangles (NFT), as well as duration of dementia and apolipoprotein E (ApoE) genotype. Our findings show that oxidative damage is quantitatively greatest early in the disease and reduces with disease progression. Surprisingly, we found that increases in A beta deposition are associated with decreased oxidative damage. These relationships are more significant in ApoE epsilon4 carriers. Moreover, neurons with NFT show a 40%-56% decrease in relative 8OHG levels compared with neurons free of NFT. Our observations indicate that increased oxidative damage is an early event in AD that decreases with disease progression and lesion formation. These findings suggest that AD is associated with compensatory changes that reduce damage from reactive oxygen." @default.
- W1542215809 created "2016-06-24" @default.
- W1542215809 creator A5008252393 @default.
- W1542215809 creator A5021420538 @default.
- W1542215809 creator A5029571817 @default.
- W1542215809 creator A5032386151 @default.
- W1542215809 creator A5050757017 @default.
- W1542215809 creator A5058785206 @default.
- W1542215809 creator A5064105810 @default.
- W1542215809 creator A5067709976 @default.
- W1542215809 creator A5067804516 @default.
- W1542215809 creator A5072042064 @default.
- W1542215809 creator A5072415195 @default.
- W1542215809 creator A5085648694 @default.
- W1542215809 creator A5086751595 @default.
- W1542215809 creator A5088123955 @default.
- W1542215809 date "2001-08-01" @default.
- W1542215809 modified "2023-10-17" @default.
- W1542215809 title "Oxidative Damage Is the Earliest Event in Alzheimer Disease" @default.
- W1542215809 cites W1222036190 @default.
- W1542215809 cites W1497413374 @default.
- W1542215809 cites W1592049170 @default.
- W1542215809 cites W1662308449 @default.
- W1542215809 cites W1731253253 @default.
- W1542215809 cites W1848907877 @default.
- W1542215809 cites W1896970469 @default.
- W1542215809 cites W1975788427 @default.
- W1542215809 cites W1978254707 @default.
- W1542215809 cites W1983789627 @default.
- W1542215809 cites W1984856280 @default.
- W1542215809 cites W1985859760 @default.
- W1542215809 cites W1989178832 @default.
- W1542215809 cites W1991480450 @default.
- W1542215809 cites W1995202749 @default.
- W1542215809 cites W2003742797 @default.
- W1542215809 cites W2006409771 @default.
- W1542215809 cites W2023121717 @default.
- W1542215809 cites W2027189256 @default.
- W1542215809 cites W2028007176 @default.
- W1542215809 cites W2028488410 @default.
- W1542215809 cites W2031433969 @default.
- W1542215809 cites W2032350023 @default.
- W1542215809 cites W2035235911 @default.
- W1542215809 cites W2048360633 @default.
- W1542215809 cites W2048975745 @default.
- W1542215809 cites W2049972682 @default.
- W1542215809 cites W2053097655 @default.
- W1542215809 cites W2058799638 @default.
- W1542215809 cites W2059175252 @default.
- W1542215809 cites W2060344493 @default.
- W1542215809 cites W2061500679 @default.
- W1542215809 cites W2069787626 @default.
- W1542215809 cites W2070117026 @default.
- W1542215809 cites W2085974525 @default.
- W1542215809 cites W2087292928 @default.
- W1542215809 cites W2091404872 @default.
- W1542215809 cites W2104987607 @default.
- W1542215809 cites W2106658584 @default.
- W1542215809 cites W2106900897 @default.
- W1542215809 cites W2111774300 @default.
- W1542215809 cites W2143348288 @default.
- W1542215809 cites W2158748165 @default.
- W1542215809 cites W2161201019 @default.
- W1542215809 cites W2165427528 @default.
- W1542215809 cites W2169507086 @default.
- W1542215809 cites W2171405125 @default.
- W1542215809 cites W36946629 @default.
- W1542215809 doi "https://doi.org/10.1093/jnen/60.8.759" @default.
- W1542215809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11487050" @default.
- W1542215809 hasPublicationYear "2001" @default.
- W1542215809 type Work @default.
- W1542215809 sameAs 1542215809 @default.
- W1542215809 citedByCount "1701" @default.
- W1542215809 countsByYear W15422158092012 @default.
- W1542215809 countsByYear W15422158092013 @default.
- W1542215809 countsByYear W15422158092014 @default.
- W1542215809 countsByYear W15422158092015 @default.
- W1542215809 countsByYear W15422158092016 @default.
- W1542215809 countsByYear W15422158092017 @default.
- W1542215809 countsByYear W15422158092018 @default.
- W1542215809 countsByYear W15422158092019 @default.
- W1542215809 countsByYear W15422158092020 @default.
- W1542215809 countsByYear W15422158092021 @default.
- W1542215809 countsByYear W15422158092022 @default.
- W1542215809 countsByYear W15422158092023 @default.
- W1542215809 crossrefType "journal-article" @default.
- W1542215809 hasAuthorship W1542215809A5008252393 @default.
- W1542215809 hasAuthorship W1542215809A5021420538 @default.
- W1542215809 hasAuthorship W1542215809A5029571817 @default.
- W1542215809 hasAuthorship W1542215809A5032386151 @default.
- W1542215809 hasAuthorship W1542215809A5050757017 @default.
- W1542215809 hasAuthorship W1542215809A5058785206 @default.
- W1542215809 hasAuthorship W1542215809A5064105810 @default.
- W1542215809 hasAuthorship W1542215809A5067709976 @default.
- W1542215809 hasAuthorship W1542215809A5067804516 @default.
- W1542215809 hasAuthorship W1542215809A5072042064 @default.
- W1542215809 hasAuthorship W1542215809A5072415195 @default.
- W1542215809 hasAuthorship W1542215809A5085648694 @default.