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• W1542226633 endingPage "29824" @default.
• W1542226633 startingPage "29817" @default.
• W1542226633 abstract "The nicotinic acetylcholine receptor (AChR) is phosphorylated on tyrosine both in vitro and in vivo. To identify the protein tyrosine kinase that phosphorylates the receptor, we have previously cloned and characterized two protein tyrosine kinases, Fyn and Fyk, that are highly expressed in Torpedo electric organ, a tissue enriched in the AChR. Both kinases were shown by coimmunoprecipitation to be specifically associated with the AChR. In this study, we examined the molecular basis for the interaction of Fyn and Fyk with the AChR using fusion proteins containing the SH2 domains of the two kinases as affinity reagents. The AChR bound specifically and in a protein concentration-dependent manner to the SH2 domain fusion proteins of Fyn and Fyk. Quantitation of the association revealed that the binding of the AChR to Fyn and Fyk SH2 domain fusion proteins was to a single class of saturable high affinity sites. In addition, the association of the AChR with the SH2 domain fusion proteins was dependent on tyrosine phosphorylation of the AChR and was mediated by the delta subunit of the receptor. Furthermore, upon dissociation of the AChR into subunits, the delta subunit coimmunoprecipitated with both Fyn and Fyk. These data suggest that the association of the AChR with Fyn and Fyk is mediated by an interaction of the tyrosine-phosphorylated delta subunit of the receptor with the SH2 domains of the protein tyrosine kinases." @default.
• W1542226633 created "2016-06-24" @default.
• W1542226633 creator A5040887108 @default.
• W1542226633 creator A5065713713 @default.
• W1542226633 date "1994-11-01" @default.
• W1542226633 modified "2023-09-27" @default.
• W1542226633 title "Binding of the nicotinic acetylcholine receptor to SH2 domains of Fyn and Fyk protein tyrosine kinases." @default.
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• W1542226633 doi "https://doi.org/10.1016/s0021-9258(18)43954-3" @default.
• W1542226633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7961974" @default.
• W1542226633 hasPublicationYear "1994" @default.
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