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- W1542235768 abstract "High-density lipoproteins (HDLs) are antiatherogenic through their role in reverse cholesterol transport (RCT), that is, the transfer of cholesterol from macrophages in the subendothelial space of the arterial wall to HDL carriers to the liver for disposal. Many mechanisms that increase HDL are not atheroprotective; enhancing RCT via improved cholesterol efflux or esterification is not clearly atheroprotective. Only the final RCT step, cholesterol disposal to liver via scavenger receptor class B, Type I (SR-BI) by reducing plasma HDL-C concentrations, seems to atheroprotect. This chapter discusses two major points. First, a low plasma HDL-C concentration is associated with increased cardiovascular disease. Second, central fat is strongly associated with increased cardiovascular disease. It deals with discovery of compounds superior to PPARγ agonists that promote fat storage in noncentral fat depots without promoting weight gain, and the identification of the underlying cause of age-dependent insulin resistance in noncentral fat depots." @default.
- W1542235768 created "2016-06-24" @default.
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- W1542235768 date "2015-03-27" @default.
- W1542235768 modified "2023-10-12" @default.
- W1542235768 title "High‐Density Lipoprotein Therapies—Then and Now" @default.
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- W1542235768 doi "https://doi.org/10.1002/9781118828533.ch42" @default.
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