Matches in SemOpenAlex for { <https://semopenalex.org/work/W154231079> ?p ?o ?g. }
- W154231079 endingPage "904" @default.
- W154231079 startingPage "893" @default.
- W154231079 abstract "The impact of epoetin beta (recombinant human erythropoietin) on brain infarction area (BIA) and neurological status in a rat model of acute ischemic stroke (IS) induced by distal left internal carotid artery occlusion was investigated.Adult male Sprague-Dawley rats (n = 30) were categorized into group 2 (IS only) and group 3 (IS plus intraperitoneal erythropoietin 5000 IU/kg at 0, 12, and 24 hours after IS). Healthy Sprague-Dawley rats (n = 10) served as group 1.Analysis of brain tissues showed larger BIA in group 2 than in group 3 (P < 0.001). Corner test identified highest frequency of left turn in group 2 (P < 0.05). The mRNA expressions of Bax, caspase 3, interleukin 18, toll-like receptor 4, and plasminogen activator inhibitor 1 were highest, whereas Bcl-2 was lowest in group 2 (P < 0.05). Lower CXCR4 and stromal cell-derived factor 1 expressions were noted in group 2 than in group 3 (P < 0.01). Immunohistofluorescence staining showed lower expressions of CXCR4, stromal cell-derived factor 1, von Willebrand factor, and doublecortin with higher number of apoptotic nuclei in group 2 than in group 3 (P < 0.001). Immunohistochemical staining demonstrated lower cellular proliferation and number of small vessels with higher glial fibrillary acid protein expression in group 2 than in group 3 (P < 0.01).Erythropoietin significantly limited BIA and improved sensorimotor dysfunction after acute IS." @default.
- W154231079 created "2016-06-24" @default.
- W154231079 creator A5003281072 @default.
- W154231079 creator A5013863560 @default.
- W154231079 creator A5020200326 @default.
- W154231079 creator A5026347136 @default.
- W154231079 creator A5026977220 @default.
- W154231079 creator A5027864839 @default.
- W154231079 creator A5028066500 @default.
- W154231079 creator A5029274782 @default.
- W154231079 creator A5033472339 @default.
- W154231079 creator A5040918042 @default.
- W154231079 creator A5055736175 @default.
- W154231079 creator A5068512351 @default.
- W154231079 date "2010-10-01" @default.
- W154231079 modified "2023-10-17" @default.
- W154231079 title "Erythropoietin markedly attenuates brain infarct size and improves neurological function in the rat." @default.
- W154231079 cites W1504583940 @default.
- W154231079 cites W1971442835 @default.
- W154231079 cites W1986639306 @default.
- W154231079 cites W2022123825 @default.
- W154231079 cites W2039707890 @default.
- W154231079 cites W2052350491 @default.
- W154231079 cites W2056268998 @default.
- W154231079 cites W2058141781 @default.
- W154231079 cites W2058554403 @default.
- W154231079 cites W2060736583 @default.
- W154231079 cites W2066323398 @default.
- W154231079 cites W2074901593 @default.
- W154231079 cites W2092103542 @default.
- W154231079 cites W2093401662 @default.
- W154231079 cites W2093445223 @default.
- W154231079 cites W2097949483 @default.
- W154231079 cites W2100167607 @default.
- W154231079 cites W2103986943 @default.
- W154231079 cites W2108089603 @default.
- W154231079 cites W2108875285 @default.
- W154231079 cites W2117752891 @default.
- W154231079 cites W2127179948 @default.
- W154231079 cites W2128143634 @default.
- W154231079 cites W2131499646 @default.
- W154231079 cites W2133496200 @default.
- W154231079 cites W2135605048 @default.
- W154231079 cites W2138595885 @default.
- W154231079 cites W2142463112 @default.
- W154231079 cites W2143058635 @default.
- W154231079 cites W2143063196 @default.
- W154231079 cites W2153190058 @default.
- W154231079 cites W2157113161 @default.
- W154231079 cites W2157312122 @default.
- W154231079 cites W2158273615 @default.
- W154231079 cites W2164763924 @default.
- W154231079 cites W2180318774 @default.
- W154231079 cites W2212003002 @default.
- W154231079 doi "https://doi.org/10.231/jim.0b013e3181e80c40" @default.
- W154231079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20601898" @default.
- W154231079 hasPublicationYear "2010" @default.
- W154231079 type Work @default.
- W154231079 sameAs 154231079 @default.
- W154231079 citedByCount "5" @default.
- W154231079 countsByYear W1542310792012 @default.
- W154231079 countsByYear W1542310792014 @default.
- W154231079 countsByYear W1542310792015 @default.
- W154231079 countsByYear W1542310792017 @default.
- W154231079 crossrefType "journal-article" @default.
- W154231079 hasAuthorship W154231079A5003281072 @default.
- W154231079 hasAuthorship W154231079A5013863560 @default.
- W154231079 hasAuthorship W154231079A5020200326 @default.
- W154231079 hasAuthorship W154231079A5026347136 @default.
- W154231079 hasAuthorship W154231079A5026977220 @default.
- W154231079 hasAuthorship W154231079A5027864839 @default.
- W154231079 hasAuthorship W154231079A5028066500 @default.
- W154231079 hasAuthorship W154231079A5029274782 @default.
- W154231079 hasAuthorship W154231079A5033472339 @default.
- W154231079 hasAuthorship W154231079A5040918042 @default.
- W154231079 hasAuthorship W154231079A5055736175 @default.
- W154231079 hasAuthorship W154231079A5068512351 @default.
- W154231079 hasConcept C126322002 @default.
- W154231079 hasConcept C129470790 @default.
- W154231079 hasConcept C13373296 @default.
- W154231079 hasConcept C134018914 @default.
- W154231079 hasConcept C142724271 @default.
- W154231079 hasConcept C170493617 @default.
- W154231079 hasConcept C204232928 @default.
- W154231079 hasConcept C2776464000 @default.
- W154231079 hasConcept C2776610909 @default.
- W154231079 hasConcept C2778534260 @default.
- W154231079 hasConcept C2780495277 @default.
- W154231079 hasConcept C2781461022 @default.
- W154231079 hasConcept C529278444 @default.
- W154231079 hasConcept C71924100 @default.
- W154231079 hasConceptScore W154231079C126322002 @default.
- W154231079 hasConceptScore W154231079C129470790 @default.
- W154231079 hasConceptScore W154231079C13373296 @default.
- W154231079 hasConceptScore W154231079C134018914 @default.
- W154231079 hasConceptScore W154231079C142724271 @default.
- W154231079 hasConceptScore W154231079C170493617 @default.
- W154231079 hasConceptScore W154231079C204232928 @default.