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- W1542374145 abstract "Objectives: To investigate the effect of a three-day trail run on markers of muscle damage and inflammation in recreational runners. Method: An observational cohort study was conducted on 19 recreational male (n=6) and female (n=13) athletes during a 95km trail run consisting of three stages, covering 29.3, 37.9 and 27.8 km with peak elevation gains and losses of 1226 and 1231m, respectively. Main Outcome Measures: Pre-and post-stage and 24 and 72 h post-race concentrations of serum creatine phosphokinase (CPK), high sensitivity C-reactive Protein (hsCRP), cortisol, cardiac Troponin T (cTnT), and osmolality (sOsm) as well as urinary myoglobin (uMb), changes in body mass, delayed onset muscle soreness (DOMS) and thigh circumference (TC) were measured. Continuous recordings of heart rate (HR) and intestinal temperature (Tintest ) were made throughout each stage. Results: Heart rate ranged between 77 and 83% age-predicted-maximum (APmax) and Tintest between 36.1 and 40.2 oC during the three stages. Significant rises in mean serum CPK, hsCRP, sOsm and blood neutrophil count reached peak concentrations of 1488U/L, 8.91mg/l, 298mosm/L and 10.21 10^9/L (p≤0.001), respectively. No evidence of elevations in uMb and cTnT were detected. The stage-induced increments in DOMS correlated positively with CPK, r=0.71; 95% CI [0.62, 0.78], TC decreased significantly post S1post and S2post (p≤0.05) and a maximum mean body mass loss of 3.09% (±1.04%) occurred during S2. Conclusion: Three consecutive days of 95km trail running resulted in modest increases in markers of muscle damage and inflammation, despite the maintenance of a heart rate above 77% APmax, Tintest rising above 39 C and mean body mass decrement of >2.0%." @default.
- W1542374145 created "2016-06-24" @default.
- W1542374145 creator A5020828013 @default.
- W1542374145 date "2012-01-01" @default.
- W1542374145 modified "2023-09-26" @default.
- W1542374145 title "Muscle damage and inflammation following a three-day trail run" @default.
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