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- W1542620515 abstract "Abstract Graves' disease ( GD ) is a common polygenic multifactorial autoimmune disease. Toll‐like receptors ( TLRs ) play critical roles in the activation of innate and adaptive immune responses. This study investigated the association of TLR7 and TLR8 gene polymorphisms with susceptibility of GD . Five single nucleotide polymorphisms ( SNPs ), namely, rs179019, rs179010 and rs3853839 in TLR7 and rs3764880 and rs5744088 in TLR8 , were evaluated in 332 GD patients and 351 controls using High‐Resolution Melting analysis. After adjusting for age, SNP rs179010 was found to decrease the risk of GD in females ( OR T vs C = 0.64, P = 0.004). In the additive model, the risk of GD decreased significantly as the number of T alleles increased in females [odds ratio ( OR ) = 0.67 (0.50–0.90), P = 0.007]. The multivariate logistic regression analysis confirmed the independent contribution of rs179010 to the protective effect against GD . This study indicates that rs179010 in TLR7 may be associated with the decreased susceptibility to GD in Chinese Cantonese." @default.
- W1542620515 created "2016-06-24" @default.
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- W1542620515 date "2014-11-28" @default.
- W1542620515 modified "2023-09-30" @default.
- W1542620515 title "Association of Toll-like receptor 7 and 8 gene polymorphisms with Graves' disease in Chinese Cantonese population" @default.
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- W1542620515 doi "https://doi.org/10.1111/tan.12479" @default.
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