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• W1542622476 abstract "In the present study, we examined the role of the neurokinin‐1 receptor (NK1R) in the modulation of respiratory rhythm in a functionally identified bradypnoeic region of the ventral respiratory group (VRG) in the in situ arterially perfused juvenile rat preparation. In electrophysiologically and functionally identified bradypnoeic sites corresponding to the Bötzinger complex (BötC), microinjection of the selective NK1R agonist [Sar 9 ‐Met(O 2 ) 11 ]‐substance P (SSP) produced a significant reduction in phrenic frequency mediated exclusively by an increase in expiratory duration ( T E ). The reduction was characterized by a significant increase in postinspiratory (post‐I) duration with no effect on either late‐expiratory duration (E2) or inspiratory duration ( T I ). In contrast, in a functionally identified tachypnoeic region, corresponding to the preBötzinger complex (Pre‐BötC), control microinjection of SSP elicited tachypnoea. Pretreatment with the NK1R antagonist CP99994 in the BötC significantly attenuated the bradypnoeic response to SSP injection and blunted the increase in T E duration. This effect of SSP mimicked the extension of T E produced by activation of the Hering‐Breuer reflex. Therefore, we hypothesized that activation of NK1Rs in the BötC is requisite for the expiratory‐lengthening effect of the Hering‐Breuer reflex. Unilateral electrical stimulation of the cervical vagus nerve produced bradypnoea by exclusively extending T E . Ipsilateral blockade of NK1Rs by CP99994 following blockade of the contralateral BötC by the GABA A receptor agonist muscimol significantly reduced the extension of T E produced by vagal stimulation. Results from the present study demonstrate that selective activation of NK1Rs in a functionally identified bradypnoeic region of the VRG can depress respiratory frequency by selectively lengthening post‐I duration and provide evidence that endogenous activation of NK1Rs in the BötC appears to be involved in the expiratory‐lengthening effect of the Hering‐Breuer reflex. In conclusion, our findings demonstrate that selective activation of NK1Rs in discrete regions of the VRG can exert functionally diverse effects on breathing." @default.
• W1542622476 created "2016-06-24" @default.
• W1542622476 creator A5013429688 @default.
• W1542622476 creator A5014979834 @default.
• W1542622476 date "2006-09-06" @default.
• W1542622476 modified "2023-10-18" @default.
• W1542622476 title "Neurokinin-1 receptor activation in Bötzinger complex evokes bradypnoea" @default.
• W1542622476 cites W1528079484 @default.
• W1542622476 cites W1532787109 @default.
• W1542622476 cites W1578558352 @default.
• W1542622476 cites W1791522543 @default.
• W1542622476 cites W1824793895 @default.
• W1542622476 cites W1885861019 @default.
• W1542622476 cites W1939572055 @default.
• W1542622476 cites W1943484341 @default.
• W1542622476 cites W1963746743 @default.
• W1542622476 cites W1966354546 @default.
• W1542622476 cites W1972480373 @default.
• W1542622476 cites W1977546294 @default.
• W1542622476 cites W1983775575 @default.
• W1542622476 cites W1985836140 @default.
• W1542622476 cites W1990745861 @default.
• W1542622476 cites W1991120317 @default.
• W1542622476 cites W1994230705 @default.
• W1542622476 cites W1997603485 @default.
• W1542622476 cites W2000744528 @default.
• W1542622476 cites W2001394888 @default.
• W1542622476 cites W2001767827 @default.
• W1542622476 cites W2002728692 @default.
• W1542622476 cites W2003738567 @default.
• W1542622476 cites W2006219353 @default.
• W1542622476 cites W2006410388 @default.
• W1542622476 cites W2008230320 @default.
• W1542622476 cites W2009159343 @default.
• W1542622476 cites W2011362828 @default.
• W1542622476 cites W2011678207 @default.
• W1542622476 cites W2015692972 @default.
• W1542622476 cites W2016195705 @default.
• W1542622476 cites W2017058483 @default.
• W1542622476 cites W2018799018 @default.
• W1542622476 cites W2027536438 @default.
• W1542622476 cites W2027648013 @default.
• W1542622476 cites W2037233574 @default.
• W1542622476 cites W2037688283 @default.
• W1542622476 cites W2040614569 @default.
• W1542622476 cites W2042571545 @default.
• W1542622476 cites W2042879230 @default.
• W1542622476 cites W2045712239 @default.
• W1542622476 cites W2046618353 @default.
• W1542622476 cites W2050168291 @default.
• W1542622476 cites W2060216575 @default.
• W1542622476 cites W2063630842 @default.
• W1542622476 cites W2067181640 @default.
• W1542622476 cites W2069344808 @default.
• W1542622476 cites W2069447865 @default.
• W1542622476 cites W2069709454 @default.
• W1542622476 cites W2081474897 @default.
• W1542622476 cites W2083189257 @default.
• W1542622476 cites W2086248309 @default.
• W1542622476 cites W2086255598 @default.
• W1542622476 cites W2089665943 @default.
• W1542622476 cites W2093021229 @default.
• W1542622476 cites W2093225726 @default.
• W1542622476 cites W2094444142 @default.
• W1542622476 cites W2102548400 @default.
• W1542622476 cites W2104966233 @default.
• W1542622476 cites W2108957007 @default.
• W1542622476 cites W2110756853 @default.
• W1542622476 cites W2113143776 @default.
• W1542622476 cites W2116099756 @default.
• W1542622476 cites W2133236751 @default.
• W1542622476 cites W2135526008 @default.
• W1542622476 cites W2141545336 @default.
• W1542622476 cites W2142990168 @default.
• W1542622476 cites W2150595146 @default.
• W1542622476 cites W2156302632 @default.
• W1542622476 cites W2165525801 @default.
• W1542622476 cites W2281172766 @default.
• W1542622476 cites W2324830287 @default.
• W1542622476 cites W2378610320 @default.
• W1542622476 cites W2748123803 @default.
• W1542622476 cites W3092805160 @default.
• W1542622476 cites W4244992753 @default.
• W1542622476 doi "https://doi.org/10.1113/jphysiol.2006.114314" @default.
• W1542622476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1995693" @default.
• W1542622476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16825299" @default.
• W1542622476 hasPublicationYear "2006" @default.
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