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• W1542642891 startingPage "155" @default.
• W1542642891 abstract "This review describes a series of studies on the tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in various experimental animal model systems, their abilities to form PAH–DNA adducts in target tissues, and their abilities to mutate ras oncogenes in PAH-induced tumors. The review is limited to those PAHs that do not contain nitrogen, for which ras mutations have been detected in induced tumors, and for which some information is available about the structures of the DNA adducts induced in the target tissue. In general, PAHs that form DNA adducts at deoxyadenosine induce mutations at codon 61, whereas those PAHs that form DNA adducts at deoxyguanosine primarily induce mutations at codons 12 or 13. Those PAHs that induce adducts at both bases induce both types of mutations. These correlations provide evidence for the involvement of adduct-directed mutations in ras in the etiology of these tumors. The induced mutation spectra in ras may in fact point back to the identity of the type of adduct formed." @default.
• W1542642891 created "2016-06-24" @default.
• W1542642891 creator A5014221194 @default.
• W1542642891 creator A5080154408 @default.
• W1542642891 date "1999-03-01" @default.
• W1542642891 modified "2023-09-30" @default.
• W1542642891 title "Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations1This manuscript has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. EPA and approved for publication. Mention of trade names or commercial products should not be construed as endorsement or recommendation for use.1" @default.
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• W1542642891 doi "https://doi.org/10.1016/s0027-5107(99)00016-0" @default.
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• W1542642891 hasPublicationYear "1999" @default.
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