Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542643500> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1542643500 endingPage "49" @default.
- W1542643500 startingPage "42" @default.
- W1542643500 abstract "Many volatile organic compounds (VOCs) used in work places are neurotoxic. However, it has been difficult to study the cellular mechanisms induced by a direct exposure to neurons because of their high volatility. The objective of this study was to establish a stable system for exposing brain slices to VOCs. With a conventional recording system for brain slices, it is not possible to keep a constant bath concentration of relatively highly volatile solvents, e.g. 1-bromopropane (1-BP). Here we report a new exposure system for VOCs that we developed in which a high concentration of oxygen is dissolved to a perfused medium applying a gas-liquid equilibrium, and in which the tubing is made of Teflon, non adsorptive material. Using our system, the bath concentration of the perfused 1-BP remained stable for at least 2 h in the slice chamber. Both 6.4 and 2.2 mM of 1-BP did not change the paired-pulse response, but fully suppressed long-term potentiation in the dentate gyrus (DG) of hippocampal slices obtained from rats, suggesting that 1-BP decreases synaptic plasticity in the DG at the concentrations tested. Our new system can be applicable for investigating the underlying mechanisms of the neurotoxicity of VOCs at the cellular level." @default.
- W1542643500 created "2016-06-24" @default.
- W1542643500 creator A5031284969 @default.
- W1542643500 creator A5040665098 @default.
- W1542643500 creator A5041306034 @default.
- W1542643500 creator A5061073643 @default.
- W1542643500 creator A5077242665 @default.
- W1542643500 date "2016-01-01" @default.
- W1542643500 modified "2023-09-28" @default.
- W1542643500 title "Development of a direct exposure system for studying the mechanisms of central neurotoxicity caused by volatile organic compounds" @default.
- W1542643500 cites W1973372962 @default.
- W1542643500 cites W1982780296 @default.
- W1542643500 cites W2011175220 @default.
- W1542643500 cites W2022419428 @default.
- W1542643500 cites W2026512382 @default.
- W1542643500 cites W2028793193 @default.
- W1542643500 cites W2048163354 @default.
- W1542643500 cites W2055647379 @default.
- W1542643500 cites W2056443671 @default.
- W1542643500 cites W2061822071 @default.
- W1542643500 cites W2065480345 @default.
- W1542643500 cites W2071750665 @default.
- W1542643500 cites W2084704070 @default.
- W1542643500 cites W2086533600 @default.
- W1542643500 cites W2127933607 @default.
- W1542643500 cites W2139920939 @default.
- W1542643500 doi "https://doi.org/10.2486/indhealth.2015-0076" @default.
- W1542643500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791292" @default.
- W1542643500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26320726" @default.
- W1542643500 hasPublicationYear "2016" @default.
- W1542643500 type Work @default.
- W1542643500 sameAs 1542643500 @default.
- W1542643500 citedByCount "2" @default.
- W1542643500 countsByYear W15426435002018 @default.
- W1542643500 countsByYear W15426435002021 @default.
- W1542643500 crossrefType "journal-article" @default.
- W1542643500 hasAuthorship W1542643500A5031284969 @default.
- W1542643500 hasAuthorship W1542643500A5040665098 @default.
- W1542643500 hasAuthorship W1542643500A5041306034 @default.
- W1542643500 hasAuthorship W1542643500A5061073643 @default.
- W1542643500 hasAuthorship W1542643500A5077242665 @default.
- W1542643500 hasBestOaLocation W15426435001 @default.
- W1542643500 hasConcept C106159729 @default.
- W1542643500 hasConcept C107872376 @default.
- W1542643500 hasConcept C148762608 @default.
- W1542643500 hasConcept C162324750 @default.
- W1542643500 hasConcept C169760540 @default.
- W1542643500 hasConcept C170493617 @default.
- W1542643500 hasConcept C178790620 @default.
- W1542643500 hasConcept C185592680 @default.
- W1542643500 hasConcept C25274449 @default.
- W1542643500 hasConcept C2776464000 @default.
- W1542643500 hasConcept C2779491297 @default.
- W1542643500 hasConcept C29730261 @default.
- W1542643500 hasConcept C43617362 @default.
- W1542643500 hasConcept C55493867 @default.
- W1542643500 hasConcept C86803240 @default.
- W1542643500 hasConcept C91602232 @default.
- W1542643500 hasConceptScore W1542643500C106159729 @default.
- W1542643500 hasConceptScore W1542643500C107872376 @default.
- W1542643500 hasConceptScore W1542643500C148762608 @default.
- W1542643500 hasConceptScore W1542643500C162324750 @default.
- W1542643500 hasConceptScore W1542643500C169760540 @default.
- W1542643500 hasConceptScore W1542643500C170493617 @default.
- W1542643500 hasConceptScore W1542643500C178790620 @default.
- W1542643500 hasConceptScore W1542643500C185592680 @default.
- W1542643500 hasConceptScore W1542643500C25274449 @default.
- W1542643500 hasConceptScore W1542643500C2776464000 @default.
- W1542643500 hasConceptScore W1542643500C2779491297 @default.
- W1542643500 hasConceptScore W1542643500C29730261 @default.
- W1542643500 hasConceptScore W1542643500C43617362 @default.
- W1542643500 hasConceptScore W1542643500C55493867 @default.
- W1542643500 hasConceptScore W1542643500C86803240 @default.
- W1542643500 hasConceptScore W1542643500C91602232 @default.
- W1542643500 hasIssue "1" @default.
- W1542643500 hasLocation W15426435001 @default.
- W1542643500 hasLocation W15426435002 @default.
- W1542643500 hasLocation W15426435003 @default.
- W1542643500 hasLocation W15426435004 @default.
- W1542643500 hasOpenAccess W1542643500 @default.
- W1542643500 hasPrimaryLocation W15426435001 @default.
- W1542643500 hasRelatedWork W1979335768 @default.
- W1542643500 hasRelatedWork W1981887526 @default.
- W1542643500 hasRelatedWork W2000819625 @default.
- W1542643500 hasRelatedWork W2021551531 @default.
- W1542643500 hasRelatedWork W2069794312 @default.
- W1542643500 hasRelatedWork W2077276022 @default.
- W1542643500 hasRelatedWork W2301439562 @default.
- W1542643500 hasRelatedWork W2356635623 @default.
- W1542643500 hasRelatedWork W2365277294 @default.
- W1542643500 hasRelatedWork W3211663581 @default.
- W1542643500 hasVolume "54" @default.
- W1542643500 isParatext "false" @default.
- W1542643500 isRetracted "false" @default.
- W1542643500 magId "1542643500" @default.
- W1542643500 workType "article" @default.