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- W154264524 abstract "Cell transformation in vitro is usually accompanied by alterations in morphology and growth properties which may be related directly or indirectly to malignancy. Although the initial lesion of transformation probably involves the interaction of a carcinogen with the cell genome, subsequent expression of the mutagenic event is manifested in altered cell shape, alterations in motility, spreading, and adhesive properties, loss of density-dependent growth control, loss of anchorage dependence and changes in cell surface properties. Recent evidence has suggested that many aspects of transformation may relate to changes in a delicate system of cytoplasmic microfilaments and microtubules known collectively as the cytoskeleton (Edelman 1976; Nicolson 1976). Components of the cytoskeleton play a major role in the regulation of cell form (Porter 1966; Nicolson 1976), and both microtubules and microfilaments have been shown to be involved in cell motility (Porter 1966; Allison 1973) and substrate attachment (Goldman and Follett 1970; Pollack and Rifkin 1975; Miller et al. 1977). Also, the modulation of cell surface proteins is regulated to a large extent by submembranous assemblies of microtubules and microfilaments (Edelman 1976)." @default.
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- W154264524 date "1980-01-01" @default.
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- W154264524 title "The Microtubule Cytoskeleton in Normal and Transformed Cells in Vitro" @default.
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- W154264524 doi "https://doi.org/10.1007/978-3-540-38267-6_17" @default.
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