Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542649951> ?p ?o ?g. }
- W1542649951 endingPage "1312" @default.
- W1542649951 startingPage "1301" @default.
- W1542649951 abstract "PIWI-interacting RNAs (piRNAs) have long been associated with the silencing of transposable elements (TEs). However, over 20,000 unique species of piRNAs mapped to the human genome are more than the relatively few presumably required to regulate the known human transposon classes. Here, we present the results of the first genome-wide effort to study the effects of piRNAs on gene specific DNA methylation. We found that exon-derived piRNAs consist almost universally of species with 10 or fewer genomic copies, whereas piRNAs existing in high copies originate predominately from intronic and intergenic regions. Genome-wide methylation profiling following transfection of human somatic cells with piRNA mimics revealed methylation changes at numerous genic loci in single copy piRNA-transfected cells. Moreover, genomic regions directly adjacent to differentially methylated CpG sites were enriched for sequence matches to the transfected piRNAs. These findings suggest that a subset of single copy piRNAs may be able to induce DNA methylation at non-TE genic loci, a process that may be mediated in part by direct binding to either genomic DNA or nascent mRNA near target CpG sites." @default.
- W1542649951 created "2016-06-24" @default.
- W1542649951 creator A5017134695 @default.
- W1542649951 creator A5023487411 @default.
- W1542649951 creator A5042620998 @default.
- W1542649951 date "2014-10-03" @default.
- W1542649951 modified "2023-10-16" @default.
- W1542649951 title "Epigenome-wide analysis of piRNAs in gene-specific DNA methylation" @default.
- W1542649951 cites W1603935733 @default.
- W1542649951 cites W1970698209 @default.
- W1542649951 cites W1972353480 @default.
- W1542649951 cites W1976342457 @default.
- W1542649951 cites W1977733607 @default.
- W1542649951 cites W1990654003 @default.
- W1542649951 cites W2008420899 @default.
- W1542649951 cites W2011813973 @default.
- W1542649951 cites W2012203722 @default.
- W1542649951 cites W2012453729 @default.
- W1542649951 cites W2014037052 @default.
- W1542649951 cites W2015231728 @default.
- W1542649951 cites W2015402753 @default.
- W1542649951 cites W2017364735 @default.
- W1542649951 cites W2017502278 @default.
- W1542649951 cites W2020441317 @default.
- W1542649951 cites W2028444170 @default.
- W1542649951 cites W2035930185 @default.
- W1542649951 cites W2039684583 @default.
- W1542649951 cites W2046318418 @default.
- W1542649951 cites W2053811671 @default.
- W1542649951 cites W2054073386 @default.
- W1542649951 cites W2063093796 @default.
- W1542649951 cites W2068711892 @default.
- W1542649951 cites W2071617636 @default.
- W1542649951 cites W2072407844 @default.
- W1542649951 cites W2072795057 @default.
- W1542649951 cites W2077280260 @default.
- W1542649951 cites W2079499188 @default.
- W1542649951 cites W2085880427 @default.
- W1542649951 cites W2103012554 @default.
- W1542649951 cites W2103028411 @default.
- W1542649951 cites W2105097906 @default.
- W1542649951 cites W2106557257 @default.
- W1542649951 cites W2113377893 @default.
- W1542649951 cites W2113727975 @default.
- W1542649951 cites W2117418172 @default.
- W1542649951 cites W2118420574 @default.
- W1542649951 cites W2122683221 @default.
- W1542649951 cites W2123174009 @default.
- W1542649951 cites W2140360152 @default.
- W1542649951 cites W2141829495 @default.
- W1542649951 cites W2142565421 @default.
- W1542649951 cites W2150860105 @default.
- W1542649951 cites W2158217645 @default.
- W1542649951 cites W3106354469 @default.
- W1542649951 doi "https://doi.org/10.1080/15476286.2014.996091" @default.
- W1542649951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4615395" @default.
- W1542649951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25590657" @default.
- W1542649951 hasPublicationYear "2014" @default.
- W1542649951 type Work @default.
- W1542649951 sameAs 1542649951 @default.
- W1542649951 citedByCount "54" @default.
- W1542649951 countsByYear W15426499512015 @default.
- W1542649951 countsByYear W15426499512016 @default.
- W1542649951 countsByYear W15426499512017 @default.
- W1542649951 countsByYear W15426499512018 @default.
- W1542649951 countsByYear W15426499512019 @default.
- W1542649951 countsByYear W15426499512020 @default.
- W1542649951 countsByYear W15426499512021 @default.
- W1542649951 countsByYear W15426499512022 @default.
- W1542649951 countsByYear W15426499512023 @default.
- W1542649951 crossrefType "journal-article" @default.
- W1542649951 hasAuthorship W1542649951A5017134695 @default.
- W1542649951 hasAuthorship W1542649951A5023487411 @default.
- W1542649951 hasAuthorship W1542649951A5042620998 @default.
- W1542649951 hasBestOaLocation W15426499511 @default.
- W1542649951 hasConcept C104317684 @default.
- W1542649951 hasConcept C117717151 @default.
- W1542649951 hasConcept C121912465 @default.
- W1542649951 hasConcept C136953436 @default.
- W1542649951 hasConcept C140173407 @default.
- W1542649951 hasConcept C141231307 @default.
- W1542649951 hasConcept C147724379 @default.
- W1542649951 hasConcept C150194340 @default.
- W1542649951 hasConcept C163002167 @default.
- W1542649951 hasConcept C190727270 @default.
- W1542649951 hasConcept C197077220 @default.
- W1542649951 hasConcept C4918238 @default.
- W1542649951 hasConcept C54355233 @default.
- W1542649951 hasConcept C86803240 @default.
- W1542649951 hasConceptScore W1542649951C104317684 @default.
- W1542649951 hasConceptScore W1542649951C117717151 @default.
- W1542649951 hasConceptScore W1542649951C121912465 @default.
- W1542649951 hasConceptScore W1542649951C136953436 @default.
- W1542649951 hasConceptScore W1542649951C140173407 @default.
- W1542649951 hasConceptScore W1542649951C141231307 @default.
- W1542649951 hasConceptScore W1542649951C147724379 @default.
- W1542649951 hasConceptScore W1542649951C150194340 @default.
- W1542649951 hasConceptScore W1542649951C163002167 @default.