FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542676327> ?p ?o ?g. }

• W1542676327 endingPage "563" @default.
• W1542676327 startingPage "553" @default.
• W1542676327 abstract "Eos belongs to the Ikaros family of transcription factors. It was reported to be a regulatory T cell (Treg) signature gene, to play a critical role in Treg suppressor functions, and to maintain Treg stability. We used mice with a global deficiency in Eos to re-examine the role of Eos expression in both Tregs and conventional T cells (Tconvs). Tregs from Eos-deficient (Eos(-/-)) mice developed normally, displayed a normal Treg phenotype, and exhibited normal suppressor function in vitro. Eos(-/-) Tregs were as effective as Tregs from wild-type (WT) mice in suppressing inflammation in a model of inflammatory bowel disease. Bone marrow (BM) from Eos(-/-) mice was as effective as that from WT mice in controlling T cell activation when used to reconstitute immunodeficient mice in the presence of scurfy fetal liver cells. Surprisingly, Eos was expressed in activated Tconvs and was required for IL-2 production, CD25 expression, and proliferation in vitro by CD4(+) Tconvs. Eos(-/-) mice developed more severe experimental autoimmune encephalomyelitis than WT mice, displayed increased numbers of effector T cells in the periphery and CNS, and amplified IL-17 production. In conclusion, our studies are not consistent with a role for Eos in Treg development and function but demonstrate that Eos plays an important role in the activation and differentiation of Tconvs." @default.
• W1542676327 created "2016-06-24" @default.
• W1542676327 creator A5005119540 @default.
• W1542676327 creator A5006191907 @default.
• W1542676327 creator A5027082213 @default.
• W1542676327 creator A5027130926 @default.
• W1542676327 creator A5040006686 @default.
• W1542676327 creator A5066834159 @default.
• W1542676327 creator A5069767496 @default.
• W1542676327 date "2015-07-15" @default.
• W1542676327 modified "2023-10-13" @default.
• W1542676327 title "Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells" @default.
• W1542676327 cites W1506549735 @default.
• W1542676327 cites W1563193652 @default.
• W1542676327 cites W1973949165 @default.
• W1542676327 cites W1976162569 @default.
• W1542676327 cites W1977165060 @default.
• W1542676327 cites W2000316267 @default.
• W1542676327 cites W2007317520 @default.
• W1542676327 cites W2007955797 @default.
• W1542676327 cites W2020748502 @default.
• W1542676327 cites W2036209857 @default.
• W1542676327 cites W2057373464 @default.
• W1542676327 cites W2094823633 @default.
• W1542676327 cites W2100142435 @default.
• W1542676327 cites W2102158172 @default.
• W1542676327 cites W2108819594 @default.
• W1542676327 cites W2111329034 @default.
• W1542676327 cites W2115346550 @default.
• W1542676327 cites W2145514961 @default.
• W1542676327 cites W2166282414 @default.
• W1542676327 doi "https://doi.org/10.4049/jimmunol.1500627" @default.
• W1542676327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4491037" @default.
• W1542676327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26062998" @default.
• W1542676327 hasPublicationYear "2015" @default.
• W1542676327 type Work @default.
• W1542676327 sameAs 1542676327 @default.
• W1542676327 citedByCount "34" @default.
• W1542676327 countsByYear W15426763272016 @default.
• W1542676327 countsByYear W15426763272017 @default.
• W1542676327 countsByYear W15426763272018 @default.
• W1542676327 countsByYear W15426763272019 @default.
• W1542676327 countsByYear W15426763272020 @default.
• W1542676327 countsByYear W15426763272021 @default.
• W1542676327 countsByYear W15426763272022 @default.
• W1542676327 countsByYear W15426763272023 @default.
• W1542676327 crossrefType "journal-article" @default.
• W1542676327 hasAuthorship W1542676327A5005119540 @default.
• W1542676327 hasAuthorship W1542676327A5006191907 @default.
• W1542676327 hasAuthorship W1542676327A5027082213 @default.
• W1542676327 hasAuthorship W1542676327A5027130926 @default.
• W1542676327 hasAuthorship W1542676327A5040006686 @default.
• W1542676327 hasAuthorship W1542676327A5066834159 @default.
• W1542676327 hasAuthorship W1542676327A5069767496 @default.
• W1542676327 hasBestOaLocation W15426763271 @default.
• W1542676327 hasConcept C104317684 @default.
• W1542676327 hasConcept C179185449 @default.
• W1542676327 hasConcept C203014093 @default.
• W1542676327 hasConcept C2776090121 @default.
• W1542676327 hasConcept C2776914184 @default.
• W1542676327 hasConcept C2778296632 @default.
• W1542676327 hasConcept C2778486448 @default.
• W1542676327 hasConcept C54355233 @default.
• W1542676327 hasConcept C79484868 @default.
• W1542676327 hasConcept C86803240 @default.
• W1542676327 hasConcept C8891405 @default.
• W1542676327 hasConcept C95444343 @default.
• W1542676327 hasConceptScore W1542676327C104317684 @default.
• W1542676327 hasConceptScore W1542676327C179185449 @default.
• W1542676327 hasConceptScore W1542676327C203014093 @default.
• W1542676327 hasConceptScore W1542676327C2776090121 @default.
• W1542676327 hasConceptScore W1542676327C2776914184 @default.
• W1542676327 hasConceptScore W1542676327C2778296632 @default.
• W1542676327 hasConceptScore W1542676327C2778486448 @default.
• W1542676327 hasConceptScore W1542676327C54355233 @default.
• W1542676327 hasConceptScore W1542676327C79484868 @default.
• W1542676327 hasConceptScore W1542676327C86803240 @default.
• W1542676327 hasConceptScore W1542676327C8891405 @default.
• W1542676327 hasConceptScore W1542676327C95444343 @default.
• W1542676327 hasIssue "2" @default.
• W1542676327 hasLocation W15426763271 @default.
• W1542676327 hasLocation W15426763272 @default.
• W1542676327 hasLocation W15426763273 @default.
• W1542676327 hasLocation W15426763274 @default.
• W1542676327 hasOpenAccess W1542676327 @default.
• W1542676327 hasPrimaryLocation W15426763271 @default.
• W1542676327 hasRelatedWork W1531752497 @default.
• W1542676327 hasRelatedWork W1977208635 @default.
• W1542676327 hasRelatedWork W2113345769 @default.
• W1542676327 hasRelatedWork W2158225802 @default.
• W1542676327 hasRelatedWork W2259227165 @default.
• W1542676327 hasRelatedWork W2350946838 @default.
• W1542676327 hasRelatedWork W2351867950 @default.
• W1542676327 hasRelatedWork W2381120565 @default.
• W1542676327 hasRelatedWork W2524538250 @default.
• W1542676327 hasRelatedWork W3030857689 @default.
• W1542676327 hasVolume "195" @default.
• W1542676327 isParatext "false" @default.

• next