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- W1542679244 abstract "Here we review the features and applications of some dictionaries used for classifying medicines, adverse reactions, and medical conditions, and briefly explore the concept of the anatomical–therapeutic–chemical classification of drugs, the structure of the World Health Organization's drug dictionary, and the EudraVigilance Medicinal Product Dictionary. We present the structure and hierarchy of the WHO Adverse Reaction Terminology, as well as the elements of the International Classifications of Diseases (ICD 9, ICD 9-CM, and ICD 10). We also briefly cover the SNOMED Disease Nomenclature. These adverse reactions dictionaries and disease classifications have been widely used in the pharmacovigilance environment in the past, but following the adoption of the Medical Dictionary for Regulatory Activities (MedDRA®) as an international standard in many organizations, the use of some of them in this context has declined. We present the regulatory requirements for the use of MedDRA, with information about the maintenance of the dictionary and how new terms are added and other changes effected. MedDRA is a large hierarchical multi-axial terminology that includes terms for medical diagnoses, signs and symptoms, syndromes, qualitative investigation findings, medical and surgical procedures, and social circumstances. We present details of the structure and principal conventions used in MedDRA, together with an outline of how term selection is performed. We briefly consider various approaches to database searches and data retrieval, with an outline of some of the problems relating to data analysis and tabulation. We also discuss the CIOMS initiative on Standardised MedDRA Queries and describe the work of CIOMS in producing standard definitions for adverse reactions terms." @default.
- W1542679244 created "2016-06-24" @default.
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- W1542679244 date "2011-12-02" @default.
- W1542679244 modified "2023-10-17" @default.
- W1542679244 title "Dictionaries and Coding in Pharmacovigilance" @default.
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- W1542679244 doi "https://doi.org/10.1002/9780470975053.ch10" @default.
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