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• W1542694667 abstract "Summary Production of the main virulence determinant pectate lyases (Pels) of the phytopathogenic bacterium Erwinia chrysanthemi is modulated by a complex regulatory network involving the repressor proteins KdgR, PecS and PecT and the activator systems Pir, ExpI–ExpR and CRP. Of these regulators, CRP and PecT are particularly important since the absence of CRP or a slight overproduction of PecT leads to a drastic reduction in synthesis of Pel species. Recently, it has been shown that production of Pel species is strongly reduced in an E. chrysanthemi hns mutant, suggesting an activator function of the nucleoid‐associated protein H‐NS in the expression of the pel genes. Here, we report that the reduced synthesis of Pel species in the hns mutant results from a negative control, exerted by H‐NS, on the transcription of the regulatory gene pecT . This H‐NS/PecT cascade regulation is one of the first elucidations of a positive effect of H‐NS on target gene expression. Moreover, we found that H‐NS also represses the expression of expI , expR and pel genes. H‐NS control is the result of H‐NS binding to extended regions within the pecT , expI , expR and pel genes. Investigation of the simultaneous binding of CRP, RNA polymerase (RNAP) and H‐NS on the pelD gene revealed that these three proteins form a nucleoprotein com‐plex. Together, these data indicate that, by exerting a negative control at multiple levels, H‐NS plays a crucial role in the E. chrysanthemi pel regulatory network." @default.
• W1542694667 created "2016-06-24" @default.
• W1542694667 creator A5029211736 @default.
• W1542694667 creator A5034197066 @default.
• W1542694667 date "2002-02-01" @default.
• W1542694667 modified "2023-10-18" @default.
• W1542694667 title "H-NS-dependent activation of pectate lyases synthesis in the phytopathogenic bacterium<i>Erwinia chrysanthemi</i>is mediated by the PecT repressor" @default.
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• W1542694667 doi "https://doi.org/10.1046/j.1365-2958.2002.02782.x" @default.
• W1542694667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11929528" @default.
• W1542694667 hasPublicationYear "2002" @default.
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