FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542740939> ?p ?o ?g. }

• W1542740939 endingPage "10339" @default.
• W1542740939 startingPage "10334" @default.
• W1542740939 abstract "Type II collagen, like other fibrillar collagens, is synthesized as a procollagen containing amino (NH2)-and carboxyl (COOH)-terminal extension peptides. Based on cDNA cloning of human (Baldwin, C. T., Reginato, A. M., Smith, C., Jimenez, S. A., and Prockop, D. J. (1989) Biochem. J. 262, 521-528) and rat (Kohno, K., Martin, G. R., and Yamada, Y. (1984) J. Biol. Chem. 259, 13668-13673) type II procollagen, it was concluded that much of the NH2-terminal propeptide seen in pro-alpha 1(I) was missing. Analysis of human genomic clones for type II collagen revealed an additional exon encoding a 69-amino acid cysteine-rich domain in the NH2-terminal propeptide. This exon (exon 2) is expressed in the mRNA population of chondrocytes isolated from human fetal skeleton and notochord, juvenile costal cartilage, and bovine articular cartilage. Oligonucleotide probes spanning specific exon boundaries were used to detect two populations of procollagen mRNA by Northern blot analysis. Amplification of cDNA templates using polymerase chain reaction provided direct evidence for two distinct pro-alpha 1(II) collagen mRNAs. DNA sequence analysis showed that the two mRNAs resulted from the alternative splicing of exon 2. The protein domain encoded by exon 2 is conserved between the fibrillar collagens and two other extracellular matrix proteins, thrombospondin and von Willebrand factor. In fibrillar collagens, this protein domain may play a regulatory role in fibrillogenesis and feedback inhibition of collagen biosynthesis. Consequently, the differential expression of this protein domain could alter the biosynthesis or fibril formation of type II collagen. In addition, the expression of exon 2 may be a marker for a distinct population of chondrocytes." @default.
• W1542740939 created "2016-06-24" @default.
• W1542740939 creator A5048352998 @default.
• W1542740939 creator A5082172901 @default.
• W1542740939 date "1990-06-01" @default.
• W1542740939 modified "2023-10-17" @default.
• W1542740939 title "Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA." @default.
• W1542740939 cites W1481283361 @default.
• W1542740939 cites W1503802780 @default.
• W1542740939 cites W1512958538 @default.
• W1542740939 cites W1522211375 @default.
• W1542740939 cites W1533292277 @default.
• W1542740939 cites W1550311908 @default.
• W1542740939 cites W1557792852 @default.
• W1542740939 cites W1564677921 @default.
• W1542740939 cites W1567446113 @default.
• W1542740939 cites W1707451623 @default.
• W1542740939 cites W1972969685 @default.
• W1542740939 cites W2010463792 @default.
• W1542740939 cites W2026990679 @default.
• W1542740939 cites W2029708892 @default.
• W1542740939 cites W2030763052 @default.
• W1542740939 cites W2048962670 @default.
• W1542740939 cites W2056639980 @default.
• W1542740939 cites W2058628450 @default.
• W1542740939 cites W2066188919 @default.
• W1542740939 cites W2077443612 @default.
• W1542740939 cites W2081930723 @default.
• W1542740939 cites W2091261804 @default.
• W1542740939 cites W2092189218 @default.
• W1542740939 cites W2113676927 @default.
• W1542740939 cites W2138270253 @default.
• W1542740939 cites W2149526194 @default.
• W1542740939 cites W2398689627 @default.
• W1542740939 cites W255028057 @default.
• W1542740939 cites W1972927986 @default.
• W1542740939 doi "https://doi.org/10.1016/s0021-9258(18)86950-2" @default.
• W1542740939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2355003" @default.
• W1542740939 hasPublicationYear "1990" @default.
• W1542740939 type Work @default.
• W1542740939 sameAs 1542740939 @default.
• W1542740939 citedByCount "255" @default.
• W1542740939 countsByYear W15427409392012 @default.
• W1542740939 countsByYear W15427409392013 @default.
• W1542740939 countsByYear W15427409392014 @default.
• W1542740939 countsByYear W15427409392015 @default.
• W1542740939 countsByYear W15427409392016 @default.
• W1542740939 countsByYear W15427409392017 @default.
• W1542740939 countsByYear W15427409392018 @default.
• W1542740939 countsByYear W15427409392019 @default.
• W1542740939 countsByYear W15427409392020 @default.
• W1542740939 countsByYear W15427409392021 @default.
• W1542740939 countsByYear W15427409392022 @default.
• W1542740939 countsByYear W15427409392023 @default.
• W1542740939 crossrefType "journal-article" @default.
• W1542740939 hasAuthorship W1542740939A5048352998 @default.
• W1542740939 hasAuthorship W1542740939A5082172901 @default.
• W1542740939 hasBestOaLocation W15427409391 @default.
• W1542740939 hasConcept C102063271 @default.
• W1542740939 hasConcept C104317684 @default.
• W1542740939 hasConcept C105580179 @default.
• W1542740939 hasConcept C105702510 @default.
• W1542740939 hasConcept C153911025 @default.
• W1542740939 hasConcept C167625842 @default.
• W1542740939 hasConcept C181199279 @default.
• W1542740939 hasConcept C185592680 @default.
• W1542740939 hasConcept C194583182 @default.
• W1542740939 hasConcept C2779201268 @default.
• W1542740939 hasConcept C2779664074 @default.
• W1542740939 hasConcept C2780550940 @default.
• W1542740939 hasConcept C3018824666 @default.
• W1542740939 hasConcept C41008148 @default.
• W1542740939 hasConcept C54458228 @default.
• W1542740939 hasConcept C55493867 @default.
• W1542740939 hasConcept C64348721 @default.
• W1542740939 hasConcept C67705224 @default.
• W1542740939 hasConcept C76155785 @default.
• W1542740939 hasConcept C7860815 @default.
• W1542740939 hasConcept C86803240 @default.
• W1542740939 hasConcept C95444343 @default.
• W1542740939 hasConceptScore W1542740939C102063271 @default.
• W1542740939 hasConceptScore W1542740939C104317684 @default.
• W1542740939 hasConceptScore W1542740939C105580179 @default.
• W1542740939 hasConceptScore W1542740939C105702510 @default.
• W1542740939 hasConceptScore W1542740939C153911025 @default.
• W1542740939 hasConceptScore W1542740939C167625842 @default.
• W1542740939 hasConceptScore W1542740939C181199279 @default.
• W1542740939 hasConceptScore W1542740939C185592680 @default.
• W1542740939 hasConceptScore W1542740939C194583182 @default.
• W1542740939 hasConceptScore W1542740939C2779201268 @default.
• W1542740939 hasConceptScore W1542740939C2779664074 @default.
• W1542740939 hasConceptScore W1542740939C2780550940 @default.
• W1542740939 hasConceptScore W1542740939C3018824666 @default.
• W1542740939 hasConceptScore W1542740939C41008148 @default.
• W1542740939 hasConceptScore W1542740939C54458228 @default.
• W1542740939 hasConceptScore W1542740939C55493867 @default.
• W1542740939 hasConceptScore W1542740939C64348721 @default.
• W1542740939 hasConceptScore W1542740939C67705224 @default.

• next