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• W1542855719 abstract "Through whole-cell patch recordings, γ-Aminobutyric acid A receptor (GABA <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>A</sub> R)-mediated postsynaptic currents (IPSCs) were recorded from NA(+) neurons of the ventrolateral preoptic area (VLPO) in acute brain slices. Our previous study shows that propofol enhances the inhibitory γ-aminobutyric acid receptors (GABAARs) in the NA(+) neurons, thus reduces the activity of these neurons and the release of GABA onto the NA(-) neurons. In the present experiments, we found that propofol elicit a steady and sustained outward current shift on NA(+) neurons, demonstrating that propofol can enhance tonic currents. It is noteworthy that sIPSC frequency and tonic current were increased by gaboxadol, an agonist with preferential effects on extrasynaptic GABA <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>A</sub> Rs containing α4βδ subunits. Furosemide, a selective blocker for GABA <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>A</sub> Rs containing α6 subunit, which selectively and reversibly eliminated the propofol-evoked increase in sIPSC frequency without altering the propofol-evoked tonic current. Guvacine, a GABA transport blocker, which increases ambient GABA levels, induced tonic outward currents and increase sIPSCs frequency. Thus, the extrasynaptic GABA <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>A</sub> Rs may contain α4/6βδ subunits. Since the NA(+) neurons are more sensitive to tonic inhibition induced by propofol, the extrasynaptic GABA <sub xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>A</sub> Rs in the NA(+) neurons of VLPO may be a potential therapeutic target for the treatment of insomnia, sleep fragmentation and hypnosia." @default.
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• W1542855719 date "2015-06-01" @default.
• W1542855719 modified "2023-09-27" @default.
• W1542855719 title "Propofol Mediates Ambient GABA-activated Tonic Inhibition of VLPO Noradrenalin-Excited Neurons" @default.
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• W1542855719 doi "https://doi.org/10.1109/icmtma.2015.194" @default.
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