Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542871190> ?p ?o ?g. }
- W1542871190 endingPage "425" @default.
- W1542871190 startingPage "411" @default.
- W1542871190 abstract "Publisher Summary This chapter explores the definition and mechanism of the latent reservoir, its resistance and treatment implications, and the impact of the latent reservoir on future drug development. A viral reservoir is a cell type or anatomic location in which virus or virally infected cells persist with slower replication kinetics and/or turnover rate than that of the main pool of actively replicating virus. A stable reservoir for human immunodeficiency virus type 1 (HIV‐1) is created when activated CD4+ T cells that are converting into memory T cells become infected. Viral DNA becomes integrated into the chromosomal DNA of the cell. This stable integration into the genomes of long‐lived memory cells provides a mechanism for the archiving of all major forms of virus that have circulated in an infected individual, including viral variants that have resistance to antiretroviral drugs. The chapter explores several approaches to counter these challenges, including scheduled treatment interruptions, which ultimately proved to be ineffective, the development of drugs with higher barriers to resistance, and the development of new drug classes with novel mechanisms of action. Efforts to combat the latent reservoir directly through the intensification of highly active antiretroviral therapy (HAART) and activating agents unfortunately show only limited success." @default.
- W1542871190 created "2016-06-24" @default.
- W1542871190 creator A5019175642 @default.
- W1542871190 creator A5023336784 @default.
- W1542871190 creator A5079324608 @default.
- W1542871190 creator A5083582080 @default.
- W1542871190 date "2007-01-01" @default.
- W1542871190 modified "2023-09-27" @default.
- W1542871190 title "Treatment Implications of the Latent Reservoir for HIV‐1" @default.
- W1542871190 cites W1497870368 @default.
- W1542871190 cites W1976828027 @default.
- W1542871190 cites W1977074734 @default.
- W1542871190 cites W1996604523 @default.
- W1542871190 cites W2011626958 @default.
- W1542871190 cites W2011630381 @default.
- W1542871190 cites W2013711784 @default.
- W1542871190 cites W2015134483 @default.
- W1542871190 cites W2026323517 @default.
- W1542871190 cites W2030844138 @default.
- W1542871190 cites W2034360565 @default.
- W1542871190 cites W2049772283 @default.
- W1542871190 cites W2051269276 @default.
- W1542871190 cites W2053570554 @default.
- W1542871190 cites W2057426739 @default.
- W1542871190 cites W2060829964 @default.
- W1542871190 cites W2073036247 @default.
- W1542871190 cites W2080237955 @default.
- W1542871190 cites W2090238266 @default.
- W1542871190 cites W2090646713 @default.
- W1542871190 cites W2097726246 @default.
- W1542871190 cites W2101516953 @default.
- W1542871190 cites W2104514309 @default.
- W1542871190 cites W2116618689 @default.
- W1542871190 cites W2120830682 @default.
- W1542871190 cites W2125638681 @default.
- W1542871190 cites W2127672164 @default.
- W1542871190 cites W2135547889 @default.
- W1542871190 cites W2137728388 @default.
- W1542871190 cites W2137795402 @default.
- W1542871190 cites W2137903260 @default.
- W1542871190 cites W2139250164 @default.
- W1542871190 cites W2143726534 @default.
- W1542871190 cites W2143763222 @default.
- W1542871190 cites W2149767613 @default.
- W1542871190 cites W2156065260 @default.
- W1542871190 cites W2158934536 @default.
- W1542871190 cites W2163921097 @default.
- W1542871190 cites W2164167813 @default.
- W1542871190 cites W2165473677 @default.
- W1542871190 cites W2166861522 @default.
- W1542871190 cites W2171136144 @default.
- W1542871190 cites W2171196763 @default.
- W1542871190 cites W2331670444 @default.
- W1542871190 cites W2427700717 @default.
- W1542871190 cites W4230958379 @default.
- W1542871190 doi "https://doi.org/10.1016/s1054-3589(07)55012-x" @default.
- W1542871190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17586322" @default.
- W1542871190 hasPublicationYear "2007" @default.
- W1542871190 type Work @default.
- W1542871190 sameAs 1542871190 @default.
- W1542871190 citedByCount "16" @default.
- W1542871190 countsByYear W15428711902012 @default.
- W1542871190 countsByYear W15428711902013 @default.
- W1542871190 crossrefType "book-chapter" @default.
- W1542871190 hasAuthorship W1542871190A5019175642 @default.
- W1542871190 hasAuthorship W1542871190A5023336784 @default.
- W1542871190 hasAuthorship W1542871190A5079324608 @default.
- W1542871190 hasAuthorship W1542871190A5083582080 @default.
- W1542871190 hasConcept C104317684 @default.
- W1542871190 hasConcept C111472728 @default.
- W1542871190 hasConcept C114851261 @default.
- W1542871190 hasConcept C138885662 @default.
- W1542871190 hasConcept C140704245 @default.
- W1542871190 hasConcept C141231307 @default.
- W1542871190 hasConcept C142462285 @default.
- W1542871190 hasConcept C159047783 @default.
- W1542871190 hasConcept C18903297 @default.
- W1542871190 hasConcept C203014093 @default.
- W1542871190 hasConcept C2522874641 @default.
- W1542871190 hasConcept C2780035454 @default.
- W1542871190 hasConcept C2910737674 @default.
- W1542871190 hasConcept C2993143319 @default.
- W1542871190 hasConcept C3013748606 @default.
- W1542871190 hasConcept C54355233 @default.
- W1542871190 hasConcept C57473165 @default.
- W1542871190 hasConcept C86803240 @default.
- W1542871190 hasConcept C89611455 @default.
- W1542871190 hasConcept C98274493 @default.
- W1542871190 hasConceptScore W1542871190C104317684 @default.
- W1542871190 hasConceptScore W1542871190C111472728 @default.
- W1542871190 hasConceptScore W1542871190C114851261 @default.
- W1542871190 hasConceptScore W1542871190C138885662 @default.
- W1542871190 hasConceptScore W1542871190C140704245 @default.
- W1542871190 hasConceptScore W1542871190C141231307 @default.
- W1542871190 hasConceptScore W1542871190C142462285 @default.
- W1542871190 hasConceptScore W1542871190C159047783 @default.
- W1542871190 hasConceptScore W1542871190C18903297 @default.
- W1542871190 hasConceptScore W1542871190C203014093 @default.