Matches in SemOpenAlex for { <https://semopenalex.org/work/W1542899887> ?p ?o ?g. }
- W1542899887 endingPage "15627" @default.
- W1542899887 startingPage "15610" @default.
- W1542899887 abstract "ENO1 plays a paradoxical role in driving the pathogenesis of tumors. However, the clinical significance of ENO1 expression remains unclear and its function and modulatory mechanisms have never been reported in endometrial carcinoma (EC). In this study, ENO1 silencing significantly reduced cell glycolysis, proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo by modulating p85 suppression. This in turn mediated inactivation of PI3K/AKT signaling and its downstream signals including glycolysis, cell cycle progression, and epithelial-mesenchymal transition (EMT)-associated genes. These effects on glycolysis and cell growth were not observed after ENO1 suppression in normal human endometrial epithelial cells (HEEC). Knocking down ENO1 could significantly enhance the sensitivity of EC cells to cisplatin (DDP) and markedly inhibited the growth of EC xenografts in vivo. In clinical samples, EC tissues exhibited higher expression levels of ENO1 mRNA and protein compared with normal endometrium tissues. Patients with higher ENO1 expression had a markedly shorter overall survival than patients with low ENO1 expression. We conclude that ENO1 favors carcinogenesis, representing a potential target for gene-based therapy." @default.
- W1542899887 created "2016-06-24" @default.
- W1542899887 creator A5010716174 @default.
- W1542899887 creator A5012816472 @default.
- W1542899887 creator A5016185718 @default.
- W1542899887 creator A5022963714 @default.
- W1542899887 creator A5028992723 @default.
- W1542899887 creator A5034544317 @default.
- W1542899887 creator A5037238652 @default.
- W1542899887 creator A5053948828 @default.
- W1542899887 creator A5055645421 @default.
- W1542899887 creator A5056813172 @default.
- W1542899887 creator A5061457824 @default.
- W1542899887 creator A5064249883 @default.
- W1542899887 creator A5067203074 @default.
- W1542899887 creator A5071974588 @default.
- W1542899887 creator A5075998876 @default.
- W1542899887 creator A5082638187 @default.
- W1542899887 creator A5091632977 @default.
- W1542899887 date "2015-04-24" @default.
- W1542899887 modified "2023-10-17" @default.
- W1542899887 title "Enolase-1 is a therapeutic target in endometrial carcinoma" @default.
- W1542899887 cites W1551034491 @default.
- W1542899887 cites W1576299870 @default.
- W1542899887 cites W1891733505 @default.
- W1542899887 cites W1966900644 @default.
- W1542899887 cites W1968651533 @default.
- W1542899887 cites W1971373526 @default.
- W1542899887 cites W1979104079 @default.
- W1542899887 cites W1987380441 @default.
- W1542899887 cites W1990673250 @default.
- W1542899887 cites W1994242450 @default.
- W1542899887 cites W1995431293 @default.
- W1542899887 cites W2001995407 @default.
- W1542899887 cites W2003322006 @default.
- W1542899887 cites W2006107811 @default.
- W1542899887 cites W2006444511 @default.
- W1542899887 cites W2008364371 @default.
- W1542899887 cites W2010869804 @default.
- W1542899887 cites W2012145163 @default.
- W1542899887 cites W2014031706 @default.
- W1542899887 cites W2022333130 @default.
- W1542899887 cites W2024275092 @default.
- W1542899887 cites W2024400556 @default.
- W1542899887 cites W2028897202 @default.
- W1542899887 cites W2033516186 @default.
- W1542899887 cites W2034400467 @default.
- W1542899887 cites W2035258932 @default.
- W1542899887 cites W2037639799 @default.
- W1542899887 cites W2043669151 @default.
- W1542899887 cites W2045448921 @default.
- W1542899887 cites W2046928159 @default.
- W1542899887 cites W2046984465 @default.
- W1542899887 cites W2058218780 @default.
- W1542899887 cites W2062644593 @default.
- W1542899887 cites W2067872596 @default.
- W1542899887 cites W2072939418 @default.
- W1542899887 cites W2074183372 @default.
- W1542899887 cites W2077036618 @default.
- W1542899887 cites W2077148929 @default.
- W1542899887 cites W2083829813 @default.
- W1542899887 cites W2092900662 @default.
- W1542899887 cites W2097259163 @default.
- W1542899887 cites W2111015378 @default.
- W1542899887 cites W2113810141 @default.
- W1542899887 cites W2128751931 @default.
- W1542899887 cites W2129526111 @default.
- W1542899887 cites W2132685226 @default.
- W1542899887 cites W2158971892 @default.
- W1542899887 cites W2161817637 @default.
- W1542899887 cites W2165577181 @default.
- W1542899887 cites W2165796043 @default.
- W1542899887 cites W2169591849 @default.
- W1542899887 cites W2171026968 @default.
- W1542899887 cites W271570111 @default.
- W1542899887 doi "https://doi.org/10.18632/oncotarget.3639" @default.
- W1542899887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4558174" @default.
- W1542899887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25951350" @default.
- W1542899887 hasPublicationYear "2015" @default.
- W1542899887 type Work @default.
- W1542899887 sameAs 1542899887 @default.
- W1542899887 citedByCount "48" @default.
- W1542899887 countsByYear W15428998872015 @default.
- W1542899887 countsByYear W15428998872016 @default.
- W1542899887 countsByYear W15428998872017 @default.
- W1542899887 countsByYear W15428998872018 @default.
- W1542899887 countsByYear W15428998872019 @default.
- W1542899887 countsByYear W15428998872020 @default.
- W1542899887 countsByYear W15428998872021 @default.
- W1542899887 countsByYear W15428998872022 @default.
- W1542899887 countsByYear W15428998872023 @default.
- W1542899887 crossrefType "journal-article" @default.
- W1542899887 hasAuthorship W1542899887A5010716174 @default.
- W1542899887 hasAuthorship W1542899887A5012816472 @default.
- W1542899887 hasAuthorship W1542899887A5016185718 @default.
- W1542899887 hasAuthorship W1542899887A5022963714 @default.
- W1542899887 hasAuthorship W1542899887A5028992723 @default.
- W1542899887 hasAuthorship W1542899887A5034544317 @default.