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- W1543004714 abstract "The bacterial flagellar switch that controls the direction of flagellar rotation during Chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation. Here, we used high-resolution optical microscopy to observe switching of single motors and uncover the stochastic multistate nature of the switch. Our observations are in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread-the stochastic growth and shrinkage of domains of adjacent subunits sharing a particular conformational state. We expect that conformational spread will be important in explaining cooperativity in other large signaling complexes." @default.
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- W1543004714 date "2010-01-01" @default.
- W1543004714 modified "2023-09-24" @default.
- W1543004714 title "Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch" @default.
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