FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543096777> ?p ?o ?g. }

• W1543096777 abstract "Simulations of asexual populations undergoing continual adaptation present a definite prediction: mutator hitchhiking should drive the mutation rate upwards in an asexual population until it reaches an intolerable level, at which point the population will be driven extinct. Experimental studies have shown that a mutator allele can readily hitchhike to fixation with beneficial mutations in an asexual population having a low, wildtype mutation rate. Using Eshcerichia coli, I show that a genotype bearing two mutator alleles can supplant an asexual population already fixed for one mutator allele. My results provide experimental support for recent theory predicting that mutator alleles will tend to accumulate in asexual populations by hitchhiking with beneficial mutations, causing an ever-higher genomic mutation rate. Interestingly, results from recent simulations also suggest that the deleterious mutational load which accompanies an increased mutation rate is not immediately incurred. The delay in accruing a mutational load may potentially allow a succession of mutator hitch hiking events to occur before the cost of the initial hitchhiking event is incurred. Ultimately, mutation rates in asexual populations may evolve upwards to a rate that threatens extinction due to overwhelming mutational pressure. To test this prediction, I established independent populations of E. coli bearing either a singleor double-mutator genotype and propagated them for several thousand generations. At the conclusion of the experiment, the growth rate of the single-mutator populations had risen substantially, consistent with the substitution of beneficial mutations; in contrast, the growth rate of the double-mutator populations had fallen significantly, consistent with erosion of fitness by deleterious mutations. In addition, both sets of populations had maintained the mutation rate present at the outset of the experiment. Strikingly, the experiment seems to have provided evidence of mutation-driven fitness decline in the double-mutator populations despite the presence of beneficial mutations. I address the experimental results in the context of theoretical predication of fitness decline at a high mutation rates. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Biology First Advisor Paul Sniegowski" @default.
• W1543096777 created "2016-06-24" @default.
• W1543096777 creator A5055344574 @default.
• W1543096777 date "2012-01-01" @default.
• W1543096777 modified "2023-09-26" @default.
• W1543096777 title "The evolution of a high mutation rate and declining fitness in asexual populations" @default.
• W1543096777 cites W1476588 @default.
• W1543096777 cites W1491876634 @default.
• W1543096777 cites W1509558837 @default.
• W1543096777 cites W1532181314 @default.
• W1543096777 cites W1533555842 @default.
• W1543096777 cites W1543102554 @default.
• W1543096777 cites W1544605831 @default.
• W1543096777 cites W1549102133 @default.
• W1543096777 cites W1550165896 @default.
• W1543096777 cites W1563789515 @default.
• W1543096777 cites W1566245339 @default.
• W1543096777 cites W1691962367 @default.
• W1543096777 cites W1736186606 @default.
• W1543096777 cites W1768787945 @default.
• W1543096777 cites W1782193066 @default.
• W1543096777 cites W1842944877 @default.
• W1543096777 cites W1879472236 @default.
• W1543096777 cites W1907834430 @default.
• W1543096777 cites W1913707695 @default.
• W1543096777 cites W1930328714 @default.
• W1543096777 cites W1951480739 @default.
• W1543096777 cites W1955582561 @default.
• W1543096777 cites W1957128425 @default.
• W1543096777 cites W1960351623 @default.
• W1543096777 cites W1960610464 @default.
• W1543096777 cites W1967600116 @default.
• W1543096777 cites W1969394745 @default.
• W1543096777 cites W1972014674 @default.
• W1543096777 cites W1977388783 @default.
• W1543096777 cites W1977745444 @default.
• W1543096777 cites W1977852064 @default.
• W1543096777 cites W1978544314 @default.
• W1543096777 cites W1978696864 @default.
• W1543096777 cites W1980167367 @default.
• W1543096777 cites W1983679519 @default.
• W1543096777 cites W1987221915 @default.
• W1543096777 cites W1991595275 @default.
• W1543096777 cites W1992915676 @default.
• W1543096777 cites W1997850663 @default.
• W1543096777 cites W2000492287 @default.
• W1543096777 cites W2001505139 @default.
• W1543096777 cites W2003215842 @default.
• W1543096777 cites W2004778468 @default.
• W1543096777 cites W2005306868 @default.
• W1543096777 cites W2007411058 @default.
• W1543096777 cites W2014496483 @default.
• W1543096777 cites W2019784560 @default.
• W1543096777 cites W2024498677 @default.
• W1543096777 cites W2026083933 @default.
• W1543096777 cites W2028224301 @default.
• W1543096777 cites W2032105952 @default.
• W1543096777 cites W2032240052 @default.
• W1543096777 cites W2036925580 @default.
• W1543096777 cites W2038600933 @default.
• W1543096777 cites W2042712534 @default.
• W1543096777 cites W2042807099 @default.
• W1543096777 cites W2045716211 @default.
• W1543096777 cites W2045765967 @default.
• W1543096777 cites W204778017 @default.
• W1543096777 cites W2048471787 @default.
• W1543096777 cites W2048896614 @default.
• W1543096777 cites W2049718034 @default.
• W1543096777 cites W2053822186 @default.
• W1543096777 cites W2054547280 @default.
• W1543096777 cites W2055633360 @default.
• W1543096777 cites W2056301301 @default.
• W1543096777 cites W2056732862 @default.
• W1543096777 cites W2057743071 @default.
• W1543096777 cites W2062594085 @default.
• W1543096777 cites W2062984704 @default.
• W1543096777 cites W2067548727 @default.
• W1543096777 cites W2068578280 @default.
• W1543096777 cites W2069094876 @default.
• W1543096777 cites W2080449796 @default.
• W1543096777 cites W2080860912 @default.
• W1543096777 cites W2082118089 @default.
• W1543096777 cites W2084076901 @default.
• W1543096777 cites W2087004016 @default.
• W1543096777 cites W2087895317 @default.
• W1543096777 cites W2091330414 @default.
• W1543096777 cites W2096368961 @default.
• W1543096777 cites W2101994201 @default.
• W1543096777 cites W2107743271 @default.
• W1543096777 cites W2111878373 @default.
• W1543096777 cites W2112570446 @default.
• W1543096777 cites W2113430775 @default.
• W1543096777 cites W2116791869 @default.
• W1543096777 cites W2116887235 @default.
• W1543096777 cites W2120289437 @default.
• W1543096777 cites W2120655331 @default.
• W1543096777 cites W2120838291 @default.
• W1543096777 cites W2123832578 @default.
• W1543096777 cites W2129432952 @default.
• W1543096777 cites W2131055368 @default.

• next