FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543102642> ?p ?o ?g. }

• W1543102642 abstract "Skin toxicity is a common side effect of radiotherapy for solid tumors. Its management can cause treatment gaps and thus can impair cancer treatment. At present, in many countries no standard recommendation for treatment of skin during radiotherapy exists. In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. We investigated the underlying molecular mechanisms and compared effects of tea extracts with the effects of epigallocatechin-gallate, the proposed most-active moiety of green tea. Data from 60 patients with cancer of the head and neck or pelvic region topically treated with green or black tea extracts were analyzed retrospectively. Tea extracts were compared for their ability to modulate IL-1β, IL-6, IL-8, TNFα and PGE2 release from human monocytes. Effects of tea extracts on 26S proteasome function were assessed. NF-κB activity was monitored by EMSAs. Viability and radiation response of macrophages after exposure to tea extracts was measured by MTT assays. Tea extracts supported the restitution of skin integrity. Tea extracts inhibited proteasome function and suppressed cytokine release. NF-κB activity was altered by tea extracts in a complex, caspase-dependent manner, which differed from the effects of epigallocatechin-gallate. Additionally, both tea extracts, as well as epigallocatechin-gallate, slightly protected macrophages from ionizing radiation Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. The molecular mechanisms underlying the beneficial effects are complex, and most likely not exclusively dependent on effects of tea polyphenols such as epigallocatechin-gallate." @default.
• W1543102642 created "2016-06-24" @default.
• W1543102642 creator A5001462136 @default.
• W1543102642 creator A5020417788 @default.
• W1543102642 creator A5035925368 @default.
• W1543102642 creator A5039693749 @default.
• W1543102642 creator A5044488631 @default.
• W1543102642 date "2006-12-01" @default.
• W1543102642 modified "2023-10-09" @default.
• W1543102642 title "The effects of tea extracts on proinflammatory signaling" @default.
• W1543102642 cites W102626522 @default.
• W1543102642 cites W119139793 @default.
• W1543102642 cites W1485472095 @default.
• W1543102642 cites W1586228578 @default.
• W1543102642 cites W1607829491 @default.
• W1543102642 cites W1878438595 @default.
• W1543102642 cites W1984055188 @default.
• W1543102642 cites W1988775004 @default.
• W1543102642 cites W1990876232 @default.
• W1543102642 cites W2003825045 @default.
• W1543102642 cites W2012908941 @default.
• W1543102642 cites W2016894937 @default.
• W1543102642 cites W2022267557 @default.
• W1543102642 cites W2023179211 @default.
• W1543102642 cites W2023437754 @default.
• W1543102642 cites W2034924616 @default.
• W1543102642 cites W2043945205 @default.
• W1543102642 cites W2057732608 @default.
• W1543102642 cites W2059167987 @default.
• W1543102642 cites W2068180652 @default.
• W1543102642 cites W2068908935 @default.
• W1543102642 cites W2096240885 @default.
• W1543102642 cites W2112808044 @default.
• W1543102642 cites W2140226147 @default.
• W1543102642 cites W2147192624 @default.
• W1543102642 cites W2173048202 @default.
• W1543102642 cites W2464428080 @default.
• W1543102642 cites W2999065750 @default.
• W1543102642 cites W4379365691 @default.
• W1543102642 cites W98899775 @default.
• W1543102642 doi "https://doi.org/10.1186/1741-7015-4-28" @default.
• W1543102642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1698929" @default.
• W1543102642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17140430" @default.
• W1543102642 hasPublicationYear "2006" @default.
• W1543102642 type Work @default.
• W1543102642 sameAs 1543102642 @default.
• W1543102642 citedByCount "45" @default.
• W1543102642 countsByYear W15431026422012 @default.
• W1543102642 countsByYear W15431026422013 @default.
• W1543102642 countsByYear W15431026422014 @default.
• W1543102642 countsByYear W15431026422015 @default.
• W1543102642 countsByYear W15431026422016 @default.
• W1543102642 countsByYear W15431026422018 @default.
• W1543102642 countsByYear W15431026422019 @default.
• W1543102642 countsByYear W15431026422020 @default.
• W1543102642 countsByYear W15431026422021 @default.
• W1543102642 countsByYear W15431026422022 @default.
• W1543102642 countsByYear W15431026422023 @default.
• W1543102642 crossrefType "journal-article" @default.
• W1543102642 hasAuthorship W1543102642A5001462136 @default.
• W1543102642 hasAuthorship W1543102642A5020417788 @default.
• W1543102642 hasAuthorship W1543102642A5035925368 @default.
• W1543102642 hasAuthorship W1543102642A5039693749 @default.
• W1543102642 hasAuthorship W1543102642A5044488631 @default.
• W1543102642 hasBestOaLocation W15431026421 @default.
• W1543102642 hasConcept C126322002 @default.
• W1543102642 hasConcept C164027704 @default.
• W1543102642 hasConcept C2776914184 @default.
• W1543102642 hasConcept C2777192995 @default.
• W1543102642 hasConcept C2778004101 @default.
• W1543102642 hasConcept C2779431889 @default.
• W1543102642 hasConcept C29730261 @default.
• W1543102642 hasConcept C55493867 @default.
• W1543102642 hasConcept C70899900 @default.
• W1543102642 hasConcept C71924100 @default.
• W1543102642 hasConcept C86803240 @default.
• W1543102642 hasConcept C98274493 @default.
• W1543102642 hasConceptScore W1543102642C126322002 @default.
• W1543102642 hasConceptScore W1543102642C164027704 @default.
• W1543102642 hasConceptScore W1543102642C2776914184 @default.
• W1543102642 hasConceptScore W1543102642C2777192995 @default.
• W1543102642 hasConceptScore W1543102642C2778004101 @default.
• W1543102642 hasConceptScore W1543102642C2779431889 @default.
• W1543102642 hasConceptScore W1543102642C29730261 @default.
• W1543102642 hasConceptScore W1543102642C55493867 @default.
• W1543102642 hasConceptScore W1543102642C70899900 @default.
• W1543102642 hasConceptScore W1543102642C71924100 @default.
• W1543102642 hasConceptScore W1543102642C86803240 @default.
• W1543102642 hasConceptScore W1543102642C98274493 @default.
• W1543102642 hasIssue "1" @default.
• W1543102642 hasLocation W15431026421 @default.
• W1543102642 hasLocation W15431026422 @default.
• W1543102642 hasLocation W15431026423 @default.
• W1543102642 hasLocation W15431026424 @default.
• W1543102642 hasLocation W15431026425 @default.
• W1543102642 hasOpenAccess W1543102642 @default.
• W1543102642 hasPrimaryLocation W15431026421 @default.
• W1543102642 hasRelatedWork W1995851064 @default.
• W1543102642 hasRelatedWork W2024962401 @default.
• W1543102642 hasRelatedWork W2059331092 @default.

• next