Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543106775> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1543106775 endingPage "555" @default.
- W1543106775 startingPage "551" @default.
- W1543106775 abstract "Human placentas were perfused in vitro through fetal vessels of a single cotyledon with a solution of tritiated androstenedione (A) or tritiated testosterone in oxygenated Krebs-Ringer bicarbonate buffer containing glucose. The same buffer, without labeled steroids, was used to perfuse the maternal side of the placenta. Fractions of unrecycled fetal and maternal perfusates were collected to estimate the steady-state rates of output into each perfusate of labeled estrone (E1) and estradiol (E2), formed by aromatization of the perfused androgens. An unequal distribution of the two estrogens was observed, i.e., a significantly larger proportion of E2 than of E1 was released to the maternal perfusate. Addition of unlabeled A or ethinyl estradiol (10(-5)M) to the fetal perfusion buffer resulted in a redistribution of the E2 output toward the fetal perfusate. These in vitro results are similar to the findings of Walsh and McCarthy, who detected by tracer experiments an unequality in the in vivo fetomaternal distribution of the output of placentally produced E1 and E2 in rhesus monkeys. These results also support the possibility of the existence of saturable specific E2 carriers in the syncytiotrophoblast, postulated by the same authors to explain their findings. However, an extrasyncytial conversion of E2 to E1 could also account for the disproportion in the relative output of the estrogens toward mother and fetus. The perfusion system used in these studies may be useful for the elucidation of factors determining the relative rates of placental secretion of steroids toward mother and fetus." @default.
- W1543106775 created "2016-06-24" @default.
- W1543106775 creator A5010647622 @default.
- W1543106775 creator A5017339168 @default.
- W1543106775 creator A5041662098 @default.
- W1543106775 creator A5051540329 @default.
- W1543106775 creator A5086827680 @default.
- W1543106775 date "1982-11-01" @default.
- W1543106775 modified "2023-10-14" @default.
- W1543106775 title "Asymmetric release of estrone and estradiol derived from labeled precursors in perfused human placentas" @default.
- W1543106775 cites W1537220258 @default.
- W1543106775 cites W1965204208 @default.
- W1543106775 cites W1966355964 @default.
- W1543106775 cites W2006154044 @default.
- W1543106775 cites W2035486814 @default.
- W1543106775 cites W2067781320 @default.
- W1543106775 cites W2069143100 @default.
- W1543106775 cites W2090402602 @default.
- W1543106775 cites W2165118718 @default.
- W1543106775 cites W2415699957 @default.
- W1543106775 doi "https://doi.org/10.1016/0002-9378(82)90226-5" @default.
- W1543106775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7137241" @default.
- W1543106775 hasPublicationYear "1982" @default.
- W1543106775 type Work @default.
- W1543106775 sameAs 1543106775 @default.
- W1543106775 citedByCount "25" @default.
- W1543106775 countsByYear W15431067752019 @default.
- W1543106775 countsByYear W15431067752020 @default.
- W1543106775 crossrefType "journal-article" @default.
- W1543106775 hasAuthorship W1543106775A5010647622 @default.
- W1543106775 hasAuthorship W1543106775A5017339168 @default.
- W1543106775 hasAuthorship W1543106775A5041662098 @default.
- W1543106775 hasAuthorship W1543106775A5051540329 @default.
- W1543106775 hasAuthorship W1543106775A5086827680 @default.
- W1543106775 hasConcept C126322002 @default.
- W1543106775 hasConcept C134018914 @default.
- W1543106775 hasConcept C146957229 @default.
- W1543106775 hasConcept C150903083 @default.
- W1543106775 hasConcept C172680121 @default.
- W1543106775 hasConcept C185592680 @default.
- W1543106775 hasConcept C202751555 @default.
- W1543106775 hasConcept C207001950 @default.
- W1543106775 hasConcept C2776683971 @default.
- W1543106775 hasConcept C2776953305 @default.
- W1543106775 hasConcept C2777164284 @default.
- W1543106775 hasConcept C2777911890 @default.
- W1543106775 hasConcept C2778656385 @default.
- W1543106775 hasConcept C2779234561 @default.
- W1543106775 hasConcept C2779315647 @default.
- W1543106775 hasConcept C2779753670 @default.
- W1543106775 hasConcept C2781112554 @default.
- W1543106775 hasConcept C54355233 @default.
- W1543106775 hasConcept C55493867 @default.
- W1543106775 hasConcept C71315377 @default.
- W1543106775 hasConcept C71924100 @default.
- W1543106775 hasConcept C86803240 @default.
- W1543106775 hasConceptScore W1543106775C126322002 @default.
- W1543106775 hasConceptScore W1543106775C134018914 @default.
- W1543106775 hasConceptScore W1543106775C146957229 @default.
- W1543106775 hasConceptScore W1543106775C150903083 @default.
- W1543106775 hasConceptScore W1543106775C172680121 @default.
- W1543106775 hasConceptScore W1543106775C185592680 @default.
- W1543106775 hasConceptScore W1543106775C202751555 @default.
- W1543106775 hasConceptScore W1543106775C207001950 @default.
- W1543106775 hasConceptScore W1543106775C2776683971 @default.
- W1543106775 hasConceptScore W1543106775C2776953305 @default.
- W1543106775 hasConceptScore W1543106775C2777164284 @default.
- W1543106775 hasConceptScore W1543106775C2777911890 @default.
- W1543106775 hasConceptScore W1543106775C2778656385 @default.
- W1543106775 hasConceptScore W1543106775C2779234561 @default.
- W1543106775 hasConceptScore W1543106775C2779315647 @default.
- W1543106775 hasConceptScore W1543106775C2779753670 @default.
- W1543106775 hasConceptScore W1543106775C2781112554 @default.
- W1543106775 hasConceptScore W1543106775C54355233 @default.
- W1543106775 hasConceptScore W1543106775C55493867 @default.
- W1543106775 hasConceptScore W1543106775C71315377 @default.
- W1543106775 hasConceptScore W1543106775C71924100 @default.
- W1543106775 hasConceptScore W1543106775C86803240 @default.
- W1543106775 hasIssue "5" @default.
- W1543106775 hasLocation W15431067751 @default.
- W1543106775 hasLocation W15431067752 @default.
- W1543106775 hasOpenAccess W1543106775 @default.
- W1543106775 hasPrimaryLocation W15431067751 @default.
- W1543106775 hasRelatedWork W1543106775 @default.
- W1543106775 hasRelatedWork W1992502576 @default.
- W1543106775 hasRelatedWork W2003738655 @default.
- W1543106775 hasRelatedWork W2032534827 @default.
- W1543106775 hasRelatedWork W2054872702 @default.
- W1543106775 hasRelatedWork W2060300693 @default.
- W1543106775 hasRelatedWork W2081054699 @default.
- W1543106775 hasRelatedWork W2086288557 @default.
- W1543106775 hasRelatedWork W2120682794 @default.
- W1543106775 hasRelatedWork W2130662388 @default.
- W1543106775 hasVolume "144" @default.
- W1543106775 isParatext "false" @default.
- W1543106775 isRetracted "false" @default.
- W1543106775 magId "1543106775" @default.
- W1543106775 workType "article" @default.