FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543177795> ?p ?o ?g. }

• W1543177795 endingPage "863" @default.
• W1543177795 startingPage "854" @default.
• W1543177795 abstract "Abstract Substance P receptor (SPR) and its naturally occurring splice‐variant, lacking the C‐terminal tail, are found in brain and spinal cord. Whether C‐terminally truncated SPR desensitizes like full‐length SPR is controversial. We used a multivaried approach to determine whether human SPR (hSPR) and a C‐terminally truncated mutant, hSPRΔ325, differ in their desensitization and internalization. In HEK‐293 cells expressing either hSPRΔ325 or hSPR, SP‐induced desensitization of the two receptors was similar when measured by inositol triphosphate accumulation or by transient translocation of coexpressed PKCβII‐GFP to the plasma membrane. Moreover, translocation of β‐arrestin 1 or 2‐GFP (βarr1‐GFP or βarr2‐GFP) to the plasma membrane, and receptor internalization were also similar. However, hSPR and hSPRΔ325 differ in their phosphorylation and in their ability to form β‐arrestin‐containing endocytic vesicles. Unlike hSPR, hSPRΔ325 is not phosphorylated to a detectable level in intact HEK293 cells, and whereas hSPR forms vesicles containing either βarr1‐GFP or βarr2‐GFP, hSPRΔ325 does not form any vesicles with βarr1‐GFP, and forms fewer vesicles with βarr2‐GFP. We conclude that truncated hSPR undergoes agonist‐dependent desensitization and internalization without detectable receptor phosphorylation." @default.
• W1543177795 created "2016-06-24" @default.
• W1543177795 creator A5039499461 @default.
• W1543177795 creator A5045680803 @default.
• W1543177795 creator A5059247721 @default.
• W1543177795 creator A5062963224 @default.
• W1543177795 creator A5070559235 @default.
• W1543177795 creator A5075649567 @default.
• W1543177795 date "2003-01-31" @default.
• W1543177795 modified "2023-10-15" @default.
• W1543177795 title "Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize" @default.
• W1543177795 cites W1537025841 @default.
• W1543177795 cites W1542228742 @default.
• W1543177795 cites W1598468222 @default.
• W1543177795 cites W1605056014 @default.
• W1543177795 cites W1650183152 @default.
• W1543177795 cites W1933410007 @default.
• W1543177795 cites W1963912362 @default.
• W1543177795 cites W1968544303 @default.
• W1543177795 cites W1969041583 @default.
• W1543177795 cites W1974628528 @default.
• W1543177795 cites W1975386197 @default.
• W1543177795 cites W1986538961 @default.
• W1543177795 cites W2005842839 @default.
• W1543177795 cites W2009144626 @default.
• W1543177795 cites W2023629636 @default.
• W1543177795 cites W2031706219 @default.
• W1543177795 cites W2038891224 @default.
• W1543177795 cites W2042748844 @default.
• W1543177795 cites W2045106976 @default.
• W1543177795 cites W2045891423 @default.
• W1543177795 cites W2061277049 @default.
• W1543177795 cites W2079688483 @default.
• W1543177795 cites W2083334427 @default.
• W1543177795 cites W2086524338 @default.
• W1543177795 cites W2087773298 @default.
• W1543177795 cites W2089330962 @default.
• W1543177795 cites W2091073917 @default.
• W1543177795 cites W2094469376 @default.
• W1543177795 cites W2094892613 @default.
• W1543177795 cites W2097446876 @default.
• W1543177795 cites W2106627591 @default.
• W1543177795 cites W2114195564 @default.
• W1543177795 cites W2125468282 @default.
• W1543177795 cites W2132987876 @default.
• W1543177795 cites W2136983454 @default.
• W1543177795 cites W2151526347 @default.
• W1543177795 cites W2166639141 @default.
• W1543177795 cites W2170384223 @default.
• W1543177795 doi "https://doi.org/10.1046/j.1471-4159.2003.01577.x" @default.
• W1543177795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12562528" @default.
• W1543177795 hasPublicationYear "2003" @default.
• W1543177795 type Work @default.
• W1543177795 sameAs 1543177795 @default.
• W1543177795 citedByCount "41" @default.
• W1543177795 countsByYear W15431777952013 @default.
• W1543177795 countsByYear W15431777952014 @default.
• W1543177795 countsByYear W15431777952015 @default.
• W1543177795 countsByYear W15431777952017 @default.
• W1543177795 countsByYear W15431777952018 @default.
• W1543177795 countsByYear W15431777952019 @default.
• W1543177795 countsByYear W15431777952020 @default.
• W1543177795 countsByYear W15431777952021 @default.
• W1543177795 crossrefType "journal-article" @default.
• W1543177795 hasAuthorship W1543177795A5039499461 @default.
• W1543177795 hasAuthorship W1543177795A5045680803 @default.
• W1543177795 hasAuthorship W1543177795A5059247721 @default.
• W1543177795 hasAuthorship W1543177795A5062963224 @default.
• W1543177795 hasAuthorship W1543177795A5070559235 @default.
• W1543177795 hasAuthorship W1543177795A5075649567 @default.
• W1543177795 hasBestOaLocation W15431777951 @default.
• W1543177795 hasConcept C118303440 @default.
• W1543177795 hasConcept C11960822 @default.
• W1543177795 hasConcept C130316041 @default.
• W1543177795 hasConcept C139770010 @default.
• W1543177795 hasConcept C170493617 @default.
• W1543177795 hasConcept C174510640 @default.
• W1543177795 hasConcept C185592680 @default.
• W1543177795 hasConcept C2776533618 @default.
• W1543177795 hasConcept C41625074 @default.
• W1543177795 hasConcept C55493867 @default.
• W1543177795 hasConcept C55938493 @default.
• W1543177795 hasConcept C86803240 @default.
• W1543177795 hasConcept C95444343 @default.
• W1543177795 hasConceptScore W1543177795C118303440 @default.
• W1543177795 hasConceptScore W1543177795C11960822 @default.
• W1543177795 hasConceptScore W1543177795C130316041 @default.
• W1543177795 hasConceptScore W1543177795C139770010 @default.
• W1543177795 hasConceptScore W1543177795C170493617 @default.
• W1543177795 hasConceptScore W1543177795C174510640 @default.
• W1543177795 hasConceptScore W1543177795C185592680 @default.
• W1543177795 hasConceptScore W1543177795C2776533618 @default.
• W1543177795 hasConceptScore W1543177795C41625074 @default.
• W1543177795 hasConceptScore W1543177795C55493867 @default.
• W1543177795 hasConceptScore W1543177795C55938493 @default.
• W1543177795 hasConceptScore W1543177795C86803240 @default.
• W1543177795 hasConceptScore W1543177795C95444343 @default.
• W1543177795 hasIssue "4" @default.

• next