FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543197907> ?p ?o ?g. }

• W1543197907 endingPage "24812" @default.
• W1543197907 startingPage "24808" @default.
• W1543197907 abstract "NGFI-B is an orphan member of the nuclear receptor superfamily encoded by an immediate-early gene. It is rapidly synthesized and phosphorylated in PC12 cells in response to nerve growth factor (NGF) and other agents and is differentially phosphorylated dependent upon the inducing stimulus. The DNA-binding domain (DBD) of NGFI-B has been expressed in bacteria and purified. The purified protein is phosphorylated by protein kinase or by extracts from NGF-treated PC12 cells. The phosphorylated residues within the DBD have been identified as Ser-340 and Ser-350. The use of mutants in which either or both of these residues were replaced with alanines revealed that phosphorylation of Ser-350, located within the A box, a motif necessary for DNA binding by NGFI-B, resulted in a decrease in binding to the NGFI-B response element, while phosphorylation of Ser-340 had little or no effect. These findings demonstrate that phosphorylation of a nuclear receptor DBD results in a change in DNA binding and provides another potential mechanism for regulating NGFI-B activity." @default.
• W1543197907 created "2016-06-24" @default.
• W1543197907 creator A5004205875 @default.
• W1543197907 creator A5062395164 @default.
• W1543197907 creator A5062895847 @default.
• W1543197907 creator A5071810640 @default.
• W1543197907 creator A5073916948 @default.
• W1543197907 date "1993-11-01" @default.
• W1543197907 modified "2023-10-03" @default.
• W1543197907 title "The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B." @default.
• W1543197907 cites W1524158037 @default.
• W1543197907 cites W1528493806 @default.
• W1543197907 cites W1968199586 @default.
• W1543197907 cites W1969349734 @default.
• W1543197907 cites W1970587959 @default.
• W1543197907 cites W1973135307 @default.
• W1543197907 cites W1979753840 @default.
• W1543197907 cites W1986309376 @default.
• W1543197907 cites W1987783037 @default.
• W1543197907 cites W1993243592 @default.
• W1543197907 cites W1997772243 @default.
• W1543197907 cites W2009274120 @default.
• W1543197907 cites W2011035028 @default.
• W1543197907 cites W2014138876 @default.
• W1543197907 cites W2023664289 @default.
• W1543197907 cites W2024308660 @default.
• W1543197907 cites W2027243420 @default.
• W1543197907 cites W2028242823 @default.
• W1543197907 cites W2037831105 @default.
• W1543197907 cites W2047466377 @default.
• W1543197907 cites W2065301449 @default.
• W1543197907 cites W2077309544 @default.
• W1543197907 cites W2078146089 @default.
• W1543197907 cites W2080669192 @default.
• W1543197907 cites W2080997610 @default.
• W1543197907 cites W2082658535 @default.
• W1543197907 cites W2082797919 @default.
• W1543197907 cites W2091309613 @default.
• W1543197907 cites W2106113241 @default.
• W1543197907 cites W2107359522 @default.
• W1543197907 doi "https://doi.org/10.1016/s0021-9258(19)74536-0" @default.
• W1543197907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8227042" @default.
• W1543197907 hasPublicationYear "1993" @default.
• W1543197907 type Work @default.
• W1543197907 sameAs 1543197907 @default.
• W1543197907 citedByCount "107" @default.
• W1543197907 countsByYear W15431979072012 @default.
• W1543197907 countsByYear W15431979072013 @default.
• W1543197907 countsByYear W15431979072014 @default.
• W1543197907 countsByYear W15431979072015 @default.
• W1543197907 countsByYear W15431979072016 @default.
• W1543197907 countsByYear W15431979072018 @default.
• W1543197907 countsByYear W15431979072019 @default.
• W1543197907 countsByYear W15431979072021 @default.
• W1543197907 countsByYear W15431979072022 @default.
• W1543197907 countsByYear W15431979072023 @default.
• W1543197907 crossrefType "journal-article" @default.
• W1543197907 hasAuthorship W1543197907A5004205875 @default.
• W1543197907 hasAuthorship W1543197907A5062395164 @default.
• W1543197907 hasAuthorship W1543197907A5062895847 @default.
• W1543197907 hasAuthorship W1543197907A5071810640 @default.
• W1543197907 hasAuthorship W1543197907A5073916948 @default.
• W1543197907 hasBestOaLocation W15431979071 @default.
• W1543197907 hasConcept C104317684 @default.
• W1543197907 hasConcept C107824862 @default.
• W1543197907 hasConcept C11960822 @default.
• W1543197907 hasConcept C153911025 @default.
• W1543197907 hasConcept C185592680 @default.
• W1543197907 hasConcept C23525593 @default.
• W1543197907 hasConcept C25166345 @default.
• W1543197907 hasConcept C2779161069 @default.
• W1543197907 hasConcept C33987129 @default.
• W1543197907 hasConcept C552990157 @default.
• W1543197907 hasConcept C55493867 @default.
• W1543197907 hasConcept C63932345 @default.
• W1543197907 hasConcept C86339819 @default.
• W1543197907 hasConcept C86803240 @default.
• W1543197907 hasConcept C95444343 @default.
• W1543197907 hasConceptScore W1543197907C104317684 @default.
• W1543197907 hasConceptScore W1543197907C107824862 @default.
• W1543197907 hasConceptScore W1543197907C11960822 @default.
• W1543197907 hasConceptScore W1543197907C153911025 @default.
• W1543197907 hasConceptScore W1543197907C185592680 @default.
• W1543197907 hasConceptScore W1543197907C23525593 @default.
• W1543197907 hasConceptScore W1543197907C25166345 @default.
• W1543197907 hasConceptScore W1543197907C2779161069 @default.
• W1543197907 hasConceptScore W1543197907C33987129 @default.
• W1543197907 hasConceptScore W1543197907C552990157 @default.
• W1543197907 hasConceptScore W1543197907C55493867 @default.
• W1543197907 hasConceptScore W1543197907C63932345 @default.
• W1543197907 hasConceptScore W1543197907C86339819 @default.
• W1543197907 hasConceptScore W1543197907C86803240 @default.
• W1543197907 hasConceptScore W1543197907C95444343 @default.
• W1543197907 hasIssue "33" @default.
• W1543197907 hasLocation W15431979071 @default.
• W1543197907 hasOpenAccess W1543197907 @default.
• W1543197907 hasPrimaryLocation W15431979071 @default.
• W1543197907 hasRelatedWork W1518355825 @default.

• next