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- W1543217210 abstract "1 The binding of [3H]-muscimol, a potent gamma-aminobutyric acid (GABA) receptor agonist, to crude membrane preparations of bovine retina was studied, using a filtration method to isolate membrane-bound ligand. 2 Specific binding was found to be saturable and occurred at two binding sites with affinity constants of 4.3 nM and 38.2 nM. 3 Binding was sodium-independent, enhanced by both freezing and Triton X-100 treatment but abolished with sodium laurylsulphate. 4 The binding sites demonstrated a high degree of pharmacological specificity, GABA being a potent displacer of [3H]-muscimol. 5 A higher degree of [3H]-muscimol binding was associated with subcellular fractions enriched with photoreceptor synaptosomes rather than with fractions enriched with conventional synaptosomes." @default.
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- W1543217210 date "1980-01-01" @default.
- W1543217210 modified "2023-09-26" @default.
- W1543217210 title "BINDING OF [3H]-MUSCIMOL, A POTENT γ-AMINOBUTYRIC ACID RECEPTOR AGONIST, TO MEMBRANES OF THE BOVINE RETINA" @default.
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- W1543217210 doi "https://doi.org/10.1111/j.1476-5381.1980.tb10934.x" @default.
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