FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543229017> ?p ?o ?g. }

• W1543229017 endingPage "314" @default.
• W1543229017 startingPage "306" @default.
• W1543229017 abstract "The pathogenic Friend virus complex is of considerable interest in that, although members of this group are genetically related, they differ markedly in biochemical and biological properties. Heteroduplex mapping of molecular clones of the Friend virus complex, which includes the replication-competent ecotropic Friend murine leukemia virus (F-MuLV) and mink cell focus-forming virus (F-MCF) and replication-defective polycythemia- and anemia-inducing strains of spleen focus-forming virus (SFFVp and SFFVa, respectively), was employed to provide insight into the molecular basis of their relationships. In heteroduplexes of F-MuLV X F-MCF, a major substitution of 0.89 kilobases in the env gene of F-MCF was discerned. Heteroduplexes of SFFVp X F-MuLV or F-MCF and SFFVa X F-MuLV or F-MCF showed several major deletions in the pol gene region and a single major deletion in the 3' half of the env gene region of SFFVp and SFFVa. A major substitution of 0.89 kilobases was mapped to the 5' end of the env deletion of SFFVp and SFFVa in heteroduplexes with F-MuLV, similar to that seen in F-MuLV X F-MCF heteroduplexes. In contrast, this env gene region was totally homologous in F-MCF X SFFVp or SFFVa and SFFVp X SFFVa heteroduplexes. Our results suggest that (i) both SFFVp and SFFVa lack part of the env gene at its 3' end, corresponding to the p15(E) coding region, (ii) major deletions occur in the pol and env genes which account for the replication defectiveness of SFFVp and SFFVa, (iii) minor substitutions occur in the gag gene region of SFFVa that are not present in SFFVp, F-MuLV, or F-MCF, (iv) a major substitution exists in the gp70 region of the env gene between F-MuLV and F-MCF that probably accounts for the differences in their host range specificities, (v) this substitution in F-MCF is identical to the gp70 part of the gp52 coding region of SFFVp and SFFVa, and (vi) heteroduplexes to F-MCF show unambiguously that no additional large substitutions are present in SFFVp or SFFVa that could account for differences in their leukemogenicity." @default.
• W1543229017 created "2016-06-24" @default.
• W1543229017 creator A5017507332 @default.
• W1543229017 creator A5027286849 @default.
• W1543229017 creator A5051134735 @default.
• W1543229017 creator A5053626123 @default.
• W1543229017 creator A5058979535 @default.
• W1543229017 creator A5069268501 @default.
• W1543229017 date "1984-08-01" @default.
• W1543229017 modified "2023-09-26" @default.
• W1543229017 title "Heteroduplex analysis of molecular clones of the pathogenic Friend virus complex: Friend murine leukemia virus, Friend mink cell focus-forming virus, and the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus" @default.
• W1543229017 cites W1024839969 @default.
• W1543229017 cites W1500112053 @default.
• W1543229017 cites W1530392303 @default.
• W1543229017 cites W1543411722 @default.
• W1543229017 cites W1548288666 @default.
• W1543229017 cites W1569809786 @default.
• W1543229017 cites W1686094598 @default.
• W1543229017 cites W1770638410 @default.
• W1543229017 cites W1884315183 @default.
• W1543229017 cites W1925604540 @default.
• W1543229017 cites W1941739095 @default.
• W1543229017 cites W1942505448 @default.
• W1543229017 cites W1954023423 @default.
• W1543229017 cites W1973684947 @default.
• W1543229017 cites W1977069628 @default.
• W1543229017 cites W1980231518 @default.
• W1543229017 cites W1981316974 @default.
• W1543229017 cites W1984686066 @default.
• W1543229017 cites W1985150901 @default.
• W1543229017 cites W1993813688 @default.
• W1543229017 cites W2012792526 @default.
• W1543229017 cites W2015639517 @default.
• W1543229017 cites W2017801198 @default.
• W1543229017 cites W2020211697 @default.
• W1543229017 cites W2025344374 @default.
• W1543229017 cites W2029356350 @default.
• W1543229017 cites W2033035349 @default.
• W1543229017 cites W2047966179 @default.
• W1543229017 cites W2049050946 @default.
• W1543229017 cites W2050804157 @default.
• W1543229017 cites W2051559781 @default.
• W1543229017 cites W2073181596 @default.
• W1543229017 cites W2075928272 @default.
• W1543229017 cites W2080554496 @default.
• W1543229017 cites W2090073458 @default.
• W1543229017 cites W2090098790 @default.
• W1543229017 cites W2117234718 @default.
• W1543229017 cites W2127392410 @default.
• W1543229017 cites W2128212228 @default.
• W1543229017 cites W2142288945 @default.
• W1543229017 cites W2151416944 @default.
• W1543229017 cites W2166887978 @default.
• W1543229017 cites W2169414553 @default.
• W1543229017 cites W2214716537 @default.
• W1543229017 cites W2318818254 @default.
• W1543229017 cites W2402396691 @default.
• W1543229017 cites W2412580131 @default.
• W1543229017 cites W1739701195 @default.
• W1543229017 doi "https://doi.org/10.1128/jvi.51.2.306-314.1984" @default.
• W1543229017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/254439" @default.
• W1543229017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6086947" @default.
• W1543229017 hasPublicationYear "1984" @default.
• W1543229017 type Work @default.
• W1543229017 sameAs 1543229017 @default.
• W1543229017 citedByCount "7" @default.
• W1543229017 crossrefType "journal-article" @default.
• W1543229017 hasAuthorship W1543229017A5017507332 @default.
• W1543229017 hasAuthorship W1543229017A5027286849 @default.
• W1543229017 hasAuthorship W1543229017A5051134735 @default.
• W1543229017 hasAuthorship W1543229017A5053626123 @default.
• W1543229017 hasAuthorship W1543229017A5058979535 @default.
• W1543229017 hasAuthorship W1543229017A5069268501 @default.
• W1543229017 hasBestOaLocation W15432290171 @default.
• W1543229017 hasConcept C104317684 @default.
• W1543229017 hasConcept C134494468 @default.
• W1543229017 hasConcept C140704245 @default.
• W1543229017 hasConcept C153911025 @default.
• W1543229017 hasConcept C159047783 @default.
• W1543229017 hasConcept C18903297 @default.
• W1543229017 hasConcept C2522874641 @default.
• W1543229017 hasConcept C2779562191 @default.
• W1543229017 hasConcept C2780754187 @default.
• W1543229017 hasConcept C54355233 @default.
• W1543229017 hasConcept C86803240 @default.
• W1543229017 hasConceptScore W1543229017C104317684 @default.
• W1543229017 hasConceptScore W1543229017C134494468 @default.
• W1543229017 hasConceptScore W1543229017C140704245 @default.
• W1543229017 hasConceptScore W1543229017C153911025 @default.
• W1543229017 hasConceptScore W1543229017C159047783 @default.
• W1543229017 hasConceptScore W1543229017C18903297 @default.
• W1543229017 hasConceptScore W1543229017C2522874641 @default.
• W1543229017 hasConceptScore W1543229017C2779562191 @default.
• W1543229017 hasConceptScore W1543229017C2780754187 @default.
• W1543229017 hasConceptScore W1543229017C54355233 @default.
• W1543229017 hasConceptScore W1543229017C86803240 @default.
• W1543229017 hasIssue "2" @default.
• W1543229017 hasLocation W15432290171 @default.

• next