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- W1543237802 abstract "The copper utilization in mutated Brindled mice is impaired. Copper accumulates in various tissues, e.g., the kidney, of the mutated mice. The renal copper binding protein is characterized as copper-thionein--metallothionein to which copper is bound. The L-[35S]cystine incorporation experiments without prior induction with copper revealed an abnormal synthesis of metallothionein in the mutated mice. Two models are proposed which link the abnormal metallothionein synthesis with an impaired copper utilization. Model 1 is an unrestrained translation of renal mRNA which codes for metallothionein. Model 2 is an impaired renal copper reabsorption resulting in a toxic intracellular copper concentration which induces metallothionein synthesis to sequester copper. The impaired copper utilization results in a fatal copper deficiency in Menkes Brindled mice." @default.
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- W1543237802 date "1980-01-01" @default.
- W1543237802 modified "2023-09-30" @default.
- W1543237802 title "Abnormal Copper-Thionein Synthesis and Impaired Copper Utilization in Mutated Brindled Mice: Model for Menkes' Disease" @default.
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- W1543237802 doi "https://doi.org/10.1093/jn/110.1.151" @default.
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