FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543243386> ?p ?o ?g. }

• W1543243386 endingPage "OED.S2855" @default.
• W1543243386 startingPage "OED.S2855" @default.
• W1543243386 abstract "Hyperhomocysteinemia has been implicated in visual dysfunction. We reported recently that mice with endogenous hyperhomocysteinemia, due to mutation of the cystathionine-β-synthase ( cbs) gene, demonstrate loss of neurons in the retinal ganglion cell (RGC) layer and other retinal layers as homocysteine levels increase. Some clinical studies implicate hyperhomocysteinemia in the pathogenesis of diabetic retinopathy, which is also characterized by RGC loss. The present study used cbs +/– mice to determine whether modest elevation of plasma homocysteine, in the presence of diabetes, accelerates neuronal cell loss. Diabetes (DB) was induced in 3 wk old cbs +/– and wildtype mice using streptozotocin; four groups of mice were studied: DB cbs +/– non-DB cbs +/– DB cbs +/+ ; non-DB cbs +/+ . One group of diabetic cbs +/– mice was maintained on a high methionine diet (HMD, 0.5% methionine drinking water) to increase plasma homocysteine slightly. Eyes were harvested at 5, 10 and 15 weeks post-onset of diabetes; retinal cryosections were examined by light microscopy and subjected to systematic morphometric analysis. Diabetic cbs +/– had significantly fewer RGCs at 5 weeks compared to age-matched, non-diabetic cbs +/– and wildtype controls (10.0 ± 0.5 versus 14.9 ± 0.5 and 15.8 ± 0.6 cells/100 μm retina length, respectively). Significant differences in retinas of DB/high homocysteine versus controls were obtained 15 wks post-onset of diabetes including fewer RGCS and decreased thickness of inner nuclear and plexiform layers. Moderate increases in plasma homocysteine coupled with diabetes cause a more dramatic alteration of retinal phenotype than elevated homocysteine or diabetes alone and suggest that diabetes accelerates the retinal neuronal death in hyperhomocysteinemic mice." @default.
• W1543243386 created "2016-06-24" @default.
• W1543243386 creator A5004543881 @default.
• W1543243386 creator A5006524742 @default.
• W1543243386 creator A5043406437 @default.
• W1543243386 creator A5044459542 @default.
• W1543243386 creator A5091310136 @default.
• W1543243386 date "2009-01-01" @default.
• W1543243386 modified "2023-10-14" @default.
• W1543243386 title "Diabetes Accelerates Retinal neuronal cell Death in A Mouse Model of endogenous Hyperhomocysteinemia" @default.
• W1543243386 cites W1959742141 @default.
• W1543243386 cites W1965047178 @default.
• W1543243386 cites W1967551315 @default.
• W1543243386 cites W1967709839 @default.
• W1543243386 cites W1980260825 @default.
• W1543243386 cites W1981931963 @default.
• W1543243386 cites W1992860572 @default.
• W1543243386 cites W1999146990 @default.
• W1543243386 cites W1999837902 @default.
• W1543243386 cites W2010355346 @default.
• W1543243386 cites W2014735208 @default.
• W1543243386 cites W2020410272 @default.
• W1543243386 cites W2022433283 @default.
• W1543243386 cites W2025945219 @default.
• W1543243386 cites W2032237444 @default.
• W1543243386 cites W2036481972 @default.
• W1543243386 cites W2045841974 @default.
• W1543243386 cites W2047746047 @default.
• W1543243386 cites W2051075706 @default.
• W1543243386 cites W2052211882 @default.
• W1543243386 cites W2054847530 @default.
• W1543243386 cites W2057246312 @default.
• W1543243386 cites W2061610905 @default.
• W1543243386 cites W2062023215 @default.
• W1543243386 cites W2082448556 @default.
• W1543243386 cites W2083555321 @default.
• W1543243386 cites W2096473999 @default.
• W1543243386 cites W2098198202 @default.
• W1543243386 cites W2103841959 @default.
• W1543243386 cites W2112729660 @default.
• W1543243386 cites W2117559470 @default.
• W1543243386 cites W2132949972 @default.
• W1543243386 cites W2144393300 @default.
• W1543243386 cites W2167954232 @default.
• W1543243386 cites W2170431784 @default.
• W1543243386 cites W2230572536 @default.
• W1543243386 doi "https://doi.org/10.4137/oed.s2855" @default.
• W1543243386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2856105" @default.
• W1543243386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20407615" @default.
• W1543243386 hasPublicationYear "2009" @default.
• W1543243386 type Work @default.
• W1543243386 sameAs 1543243386 @default.
• W1543243386 citedByCount "18" @default.
• W1543243386 countsByYear W15432433862012 @default.
• W1543243386 countsByYear W15432433862013 @default.
• W1543243386 countsByYear W15432433862014 @default.
• W1543243386 countsByYear W15432433862015 @default.
• W1543243386 countsByYear W15432433862018 @default.
• W1543243386 countsByYear W15432433862019 @default.
• W1543243386 countsByYear W15432433862020 @default.
• W1543243386 crossrefType "journal-article" @default.
• W1543243386 hasAuthorship W1543243386A5004543881 @default.
• W1543243386 hasAuthorship W1543243386A5006524742 @default.
• W1543243386 hasAuthorship W1543243386A5043406437 @default.
• W1543243386 hasAuthorship W1543243386A5044459542 @default.
• W1543243386 hasAuthorship W1543243386A5091310136 @default.
• W1543243386 hasBestOaLocation W15432433861 @default.
• W1543243386 hasConcept C118487528 @default.
• W1543243386 hasConcept C126322002 @default.
• W1543243386 hasConcept C134018914 @default.
• W1543243386 hasConcept C16525657 @default.
• W1543243386 hasConcept C169760540 @default.
• W1543243386 hasConcept C2776523773 @default.
• W1543243386 hasConcept C2777090595 @default.
• W1543243386 hasConcept C2777093970 @default.
• W1543243386 hasConcept C2777180221 @default.
• W1543243386 hasConcept C2779280383 @default.
• W1543243386 hasConcept C2779829184 @default.
• W1543243386 hasConcept C2780827179 @default.
• W1543243386 hasConcept C2780912031 @default.
• W1543243386 hasConcept C515207424 @default.
• W1543243386 hasConcept C55493867 @default.
• W1543243386 hasConcept C555293320 @default.
• W1543243386 hasConcept C71924100 @default.
• W1543243386 hasConcept C86803240 @default.
• W1543243386 hasConceptScore W1543243386C118487528 @default.
• W1543243386 hasConceptScore W1543243386C126322002 @default.
• W1543243386 hasConceptScore W1543243386C134018914 @default.
• W1543243386 hasConceptScore W1543243386C16525657 @default.
• W1543243386 hasConceptScore W1543243386C169760540 @default.
• W1543243386 hasConceptScore W1543243386C2776523773 @default.
• W1543243386 hasConceptScore W1543243386C2777090595 @default.
• W1543243386 hasConceptScore W1543243386C2777093970 @default.
• W1543243386 hasConceptScore W1543243386C2777180221 @default.
• W1543243386 hasConceptScore W1543243386C2779280383 @default.
• W1543243386 hasConceptScore W1543243386C2779829184 @default.
• W1543243386 hasConceptScore W1543243386C2780827179 @default.
• W1543243386 hasConceptScore W1543243386C2780912031 @default.

• next