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• W1543281911 abstract "Background Melanoma is the leading cause of skin cancer‐associated mortality. The vast majority of newly diagnosed melanomas are confined to the primary cutaneous site. Surgery represents the mainstay of melanoma treatment. Treatment strategies include wide excision of the primary tumour and sentinel lymph node biopsy (SLNB) to assess the status of the regional nodal basin(s). SLNB has become an important component of initial melanoma management providing accurate disease staging. Objectives To assess the effects and safety of SLNB followed by completion lymph node dissection (CLND) for the treatment of localised primary cutaneous melanoma. Search methods We searched the following databases up to February 2015: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (2015, Issue 1), MEDLINE (from 1946), EMBASE (from 1974), and LILACS ((Latin American and Caribbean Health Science Information database, from 1982). We also searched the following from inception: African Index Medicus, IndMED of India, Index Medicus for the South‐East Asia Region, and six trials registers. We checked the reference lists of included and excluded studies for further references to relevant randomised controlled trials (RCTs). We searched ISI Web of Science Conference Proceedings from inception to February 2015, and we scanned the abstracts of major dermatology and oncology conference proceedings up to 2015. Selection criteria Two review authors independently assessed all RCTs comparing SLNB followed by CLND for the treatment of primary localised cutaneous melanoma for inclusion. Primary outcome measures were overall survival and rate of treatment complications and side effects. Data collection and analysis Two review authors independently extracted and analysed data on survival and recurrence, assessed risk of bias, and collected adverse effect information from included trials. Main results We identified and included a single eligible trial comparing SLNB with observation which was published in eight different reports (from 2005 to 2014) with 2001 participants. This trial did not report on our first primary outcome of overall survival (which was also the planned primary outcome of this trial). When contacted for this important data, the trial authors stated there are numerous additional analyses that have yet to be reported for the trial. We were able however to estimate overall survival from data included in the appendix of the published report and found no evidence of benefit for SLNB for overall survival. The overall survival hazard ratio (HR) using ITT (intention‐to‐treat) analysis was 0.99 95% confidence interval [CI] 0.82 to 1.19, 1661 participants). The overall survival using ITT for intermediate thickness melanomas was (HR 0.92, 95% CI 0.73 to 1.16) and for thick melanomas it was (HR 1.15, 95% CI 0.82 to 1.61). The study did report on our second primary outcome of rate of treatment complications: short‐term surgical morbidity (30 days) in 1735 participants showed no difference between SLNB and observation (risk ratio [RR] 1.11, 955 CI 0.9 to 1.37) for wide excision of the tumour site but favoured observation for complications related to the regional nodal basin (RR 14.36, 95% CI 6.74 to 30.59). Our secondary outcomes of disease‐specific and disease‐free survival, local recurrence and distant metastases were reported. There were 1347 participants in the intermediate‐thickness melanoma group and 314 in the thick melanoma group.The study did not report the actual 10‐year melanoma‐specific survival rate for all included participants. Instead, melanoma‐specific survival rates for each group of participants: intermediate‐thickness melanoma (defined as 1.2 to 3.5 mm) and thick melanomas (defined as 3.50 mm or more) was reported. In the intermediate‐thickness melanoma group there was no statistically significant difference in disease‐specific survival between study groups at 10 years (81.4 ± 1.5% versus 78.3 ± 2.0%, HR 0.84, 95% CI 0.65 to 1.09). In the thick melanoma group, again there was no statistically significant difference in disease‐specific survival between study groups at 10 years (58.9.3 ± 4.1% versus 64.4 ± 4.6%, HR 1.12, 95% CI 0.77 to 1.64). Combining these groups there was some heterogeneity (I² = 34%) but the total HR was not statistically significant (HR 0.92, 95% CI 0.74 to 1.14). The summary estimate for disease‐free survival at 10 years favoured SLNB over observation in participants with intermediate‐thickness and thick melanomas (HR 0.75, 95% CI 0.63 to 0.89). With regard to the rate of local and regional recurrence as the site of first recurrence, a benefit of SLNB uniformly existed in both groups of participants with intermediate‐thickness and thick melanomas (RR 0.56, 95% CI 0.45 to 0.69). This is in contrast with a uniformly unfavourable effect of SLNB with regard to the rate of distant metastases as site of first recurrence, in both groups of participants with intermediate‐thickness and thick melanomas (HR 1.33, 95% CI 1.03 to 1.72). Authors' conclusions We found no evidence of improved overall survival or melanoma‐specific survival rates for participants with intermediate or thick melanomas who underwent SLNB compared with observation alone. Disease‐free survival and rate of local and regional recurrence favoured SLNB in both groups of participants with intermediate‐thickness and thick melanomas but short‐term surgical morbidity was higher in the SLNB group, especially with regard to complications in the nodal basin. The evidence for the outcomes of interest in this review is of low quality due to the risk of bias and imprecision of the estimated effects. Further research may have an important impact on our estimate of the effectiveness of SLNB in managing primary localised cutaneous melanoma. Currently this evidence is not sufficient to document a benefit of SLNB when compared to observation in individuals with primary localised cutaneous melanoma." @default.
• W1543281911 created "2016-06-24" @default.
• W1543281911 creator A5002280676 @default.
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• W1543281911 date "2015-05-16" @default.
• W1543281911 modified "2023-09-27" @default.
• W1543281911 title "Sentinel lymph node biopsy followed by lymph node dissection for localised primary cutaneous melanoma" @default.
• W1543281911 cites W1487970491 @default.
• W1543281911 cites W1511655739 @default.
• W1543281911 cites W1514700298 @default.
• W1543281911 cites W1532199737 @default.
• W1543281911 cites W1543281911 @default.
• W1543281911 cites W1585375233 @default.
• W1543281911 cites W1594293291 @default.
• W1543281911 cites W1726528668 @default.
• W1543281911 cites W1868033648 @default.
• W1543281911 cites W1951046932 @default.
• W1543281911 cites W1964032255 @default.
• W1543281911 cites W1964336392 @default.
• W1543281911 cites W1966143395 @default.
• W1543281911 cites W1978756965 @default.
• W1543281911 cites W1981989535 @default.
• W1543281911 cites W1985198734 @default.
• W1543281911 cites W1990120792 @default.
• W1543281911 cites W1996151478 @default.
• W1543281911 cites W2018862493 @default.
• W1543281911 cites W2030467932 @default.
• W1543281911 cites W2033209427 @default.
• W1543281911 cites W2036193982 @default.
• W1543281911 cites W2039232461 @default.
• W1543281911 cites W2040753000 @default.
• W1543281911 cites W2042322476 @default.
• W1543281911 cites W2053039213 @default.
• W1543281911 cites W2057714325 @default.
• W1543281911 cites W2062145108 @default.
• W1543281911 cites W2075642745 @default.
• W1543281911 cites W2086263927 @default.
• W1543281911 cites W2088095316 @default.
• W1543281911 cites W2093422846 @default.
• W1543281911 cites W2093447786 @default.
• W1543281911 cites W2096333298 @default.
• W1543281911 cites W2097400215 @default.
• W1543281911 cites W2106005668 @default.
• W1543281911 cites W2106787323 @default.
• W1543281911 cites W2107328434 @default.
• W1543281911 cites W2114611119 @default.
• W1543281911 cites W2118863192 @default.
• W1543281911 cites W2129165890 @default.
• W1543281911 cites W2131109593 @default.
• W1543281911 cites W2136421130 @default.
• W1543281911 cites W2143455014 @default.
• W1543281911 cites W2145439424 @default.
• W1543281911 cites W2145956339 @default.
• W1543281911 cites W2148785579 @default.
• W1543281911 cites W2156098321 @default.
• W1543281911 cites W2157635895 @default.
• W1543281911 cites W2157823046 @default.
• W1543281911 cites W2161438292 @default.
• W1543281911 cites W2163568480 @default.
• W1543281911 cites W2164857025 @default.
• W1543281911 cites W2169681125 @default.
• W1543281911 cites W2170756646 @default.
• W1543281911 cites W2171746061 @default.
• W1543281911 cites W2245495037 @default.
• W1543281911 cites W2321592657 @default.
• W1543281911 cites W2328204920 @default.
• W1543281911 cites W2406482027 @default.
• W1543281911 cites W2415989474 @default.
• W1543281911 cites W246286872 @default.
• W1543281911 cites W2592429207 @default.
• W1543281911 cites W4235274132 @default.
• W1543281911 cites W4238510935 @default.
• W1543281911 cites W4244068819 @default.
• W1543281911 cites W4294215472 @default.
• W1543281911 cites W6423048 @default.
• W1543281911 doi "https://doi.org/10.1002/14651858.cd010307.pub2" @default.
• W1543281911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6461196" @default.
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