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• W1543283434 abstract "The second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT II)1 randomized 2,839 patients with intracerebral hemorrhage (ICH) within 6 h of symptom onset to intensive systolic blood pressure (SBP) reduction, with a target of <140 mm Hg within 1 h, or guideline-recommended SBP reduction, with a target of <180 mm Hg using a variety of antihypertensive medications. The primary outcome was death or major disability defined by a score of 3–6 on the modified Rankin scale (mRS) at 3 months post-randomization. The proportion of subjects with death or major disability was 719 of 1,382 (52%) in the group randomized to receive intensive BP reduction compared with 785 of 1,412 (55.6%) in the group randomized to receive guideline-recommended treatment (odds ratio [OR] with intensive treatment, 0.87; 95% confidence interval [CI], 0.75–1.01; p = 0.06). In the secondary analysis, mRS grades were analyzed as an ordinal scale, which detected significantly lower mRS scores in subjects randomized to intensive SBP reduction (common OR, 0.87; 95% CI, 0.77–1.00; p = 0.04).After the publication, the Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II investigators’ prepared a report for its Data and Safety Monitoring Board to determine implications of INTERACT II on current practice and on ATACH II trial design and conduct ( Table 1).Table 1Differences between INTERACT II and ATACH II with regard to addressing common issues in trials involving patients with ICH" @default.
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• W1543283434 date "2014-06-01" @default.
• W1543283434 modified "2023-10-01" @default.
• W1543283434 title "Interpretation and Implementation of Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT II)." @default.
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• W1543283434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4132943" @default.
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