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- W1543283568 abstract "Summary Newborn mice immunized at the 3rd day of life did not produce ME-resistant antibody to sheep erythrocytes throughout the observation period of 31 days, although half of them produced ME-sensitive antibody. The interval between the appearance of ME-sensitive and ME-resistant antibodies became shorter as mice were immunized at an older age. The mice immunized at 25 days of age showed an almost completely matured type of immunologic response to sheep erythrocyte antigens. In neonatally thymectomized mice not only were the capacities for immunologic response generally suppressed, but ME-resistant antibody appeared much later than it did in control mice after injections of sheep erythrocytes. The time-course of the ME-resistant antibody response of neonatally thymectomized mice resembled that of young mice. The size of hemolysin plaques produced by spleen cells of mice 10 days of age was smaller than that observed with the spleen cells of adult mice. It is concluded that in extremely young mice the number of hemolysin plaque-forming cells is small, and also that the capacity of each antibody-producing cell is less than it is in adult mice. In neonatally thymectomized mice injected repeatedly with sheep erythrocytes, hemagglutinin titers increased to levels almost as high as those in sham-thymectomized mice that were immunized according to the same schedule. This increase in ME-resistant antibody production after repeated injections in neonatally thymectomized mice was specific for the antigen that was given." @default.
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- W1543283568 date "1967-10-01" @default.
- W1543283568 modified "2023-10-15" @default.
- W1543283568 title "Characteristics of Antibody Response in Young or Thymectomized Mice" @default.
- W1543283568 doi "https://doi.org/10.4049/jimmunol.99.4.831" @default.
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