FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543364273> ?p ?o ?g. }

• W1543364273 endingPage "724" @default.
• W1543364273 startingPage "720" @default.
• W1543364273 abstract "To explore whether homocysteine (HCy), an independent risk factor for atherosclerosis (the angiopathic effect of which occurs through the generation of superoxide anions and hydrogen peroxide, augmented by copper, the superoxide anions reacting with nitric oxide, NO, to produce peroxynitrite, a highly angiopathic free radical) and copper contribute to erectile dysfunction (ED) through similar mechanisms, by assessing their interactive effects on the relaxation of corpus cavernosum using organ-bath techniques.Cavernosal smooth muscle strips were obtained from adult New Zealand White rabbits and mounted in organ baths. After precontraction with phenylephrine (100 micromol/L), relaxation responses to carbachol or sodium nitroprusside (SNP) were assessed in the presence or absence of HCy and copper. The effects of HCy and copper in the presence of superoxide dismutase or catalase were also investigated.HCy alone inhibited carbachol-stimulated (NO-dependent) but not SNP-stimulated relaxations (NO-independent). This effect of HCy was significantly augmented by copper, which alone had no effect. The combined effect of HCy and copper was significantly (P<0.05) reversed by superoxide dismutase or catalase.HCy inhibited NO-mediated cavernosal smooth muscle relaxation, an effect that was potentiated by copper and reversed by superoxide dismutase or catalase. It is therefore proposed that the effect of HCy on cavernosal smooth muscle relaxation is mediated by an interaction between NO and superoxide anions. Moreover, HCy may constitute a new risk factor for angiopathic ED." @default.
• W1543364273 created "2016-06-24" @default.
• W1543364273 creator A5020385689 @default.
• W1543364273 creator A5063473691 @default.
• W1543364273 creator A5069057976 @default.
• W1543364273 creator A5076159672 @default.
• W1543364273 creator A5077027377 @default.
• W1543364273 creator A5077336931 @default.
• W1543364273 creator A5079736323 @default.
• W1543364273 creator A5091739167 @default.
• W1543364273 date "2001-12-25" @default.
• W1543364273 modified "2023-10-10" @default.
• W1543364273 title "The interaction of homocysteine and copper markedly inhibits the relaxation of rabbit corpus cavernosum: new risk factors for angiopathic erectile dysfunction?" @default.
• W1543364273 cites W1516636175 @default.
• W1543364273 cites W1604222082 @default.
• W1543364273 cites W1934678104 @default.
• W1543364273 cites W1966292733 @default.
• W1543364273 cites W2022901952 @default.
• W1543364273 cites W2027367805 @default.
• W1543364273 cites W2029054651 @default.
• W1543364273 cites W2047122639 @default.
• W1543364273 cites W2055703366 @default.
• W1543364273 cites W2065645881 @default.
• W1543364273 cites W2068653999 @default.
• W1543364273 cites W2093108789 @default.
• W1543364273 cites W2124378690 @default.
• W1543364273 cites W2131581679 @default.
• W1543364273 cites W2163918044 @default.
• W1543364273 cites W2169939099 @default.
• W1543364273 cites W2313326603 @default.
• W1543364273 cites W67523002 @default.
• W1543364273 cites W85096918 @default.
• W1543364273 doi "https://doi.org/10.1046/j.1464-410x.1999.00253.x" @default.
• W1543364273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10510122" @default.
• W1543364273 hasPublicationYear "2001" @default.
• W1543364273 type Work @default.
• W1543364273 sameAs 1543364273 @default.
• W1543364273 citedByCount "37" @default.
• W1543364273 countsByYear W15433642732012 @default.
• W1543364273 countsByYear W15433642732014 @default.
• W1543364273 countsByYear W15433642732015 @default.
• W1543364273 countsByYear W15433642732016 @default.
• W1543364273 countsByYear W15433642732019 @default.
• W1543364273 countsByYear W15433642732021 @default.
• W1543364273 countsByYear W15433642732022 @default.
• W1543364273 crossrefType "journal-article" @default.
• W1543364273 hasAuthorship W1543364273A5020385689 @default.
• W1543364273 hasAuthorship W1543364273A5063473691 @default.
• W1543364273 hasAuthorship W1543364273A5069057976 @default.
• W1543364273 hasAuthorship W1543364273A5076159672 @default.
• W1543364273 hasAuthorship W1543364273A5077027377 @default.
• W1543364273 hasAuthorship W1543364273A5077336931 @default.
• W1543364273 hasAuthorship W1543364273A5079736323 @default.
• W1543364273 hasAuthorship W1543364273A5091739167 @default.
• W1543364273 hasConcept C126322002 @default.
• W1543364273 hasConcept C134018914 @default.
• W1543364273 hasConcept C178790620 @default.
• W1543364273 hasConcept C181199279 @default.
• W1543364273 hasConcept C185592680 @default.
• W1543364273 hasConcept C2775838275 @default.
• W1543364273 hasConcept C2776151105 @default.
• W1543364273 hasConcept C2777615887 @default.
• W1543364273 hasConcept C2778979269 @default.
• W1543364273 hasConcept C2779610285 @default.
• W1543364273 hasConcept C2780795997 @default.
• W1543364273 hasConcept C519581460 @default.
• W1543364273 hasConcept C544778455 @default.
• W1543364273 hasConcept C55493867 @default.
• W1543364273 hasConcept C71924100 @default.
• W1543364273 hasConceptScore W1543364273C126322002 @default.
• W1543364273 hasConceptScore W1543364273C134018914 @default.
• W1543364273 hasConceptScore W1543364273C178790620 @default.
• W1543364273 hasConceptScore W1543364273C181199279 @default.
• W1543364273 hasConceptScore W1543364273C185592680 @default.
• W1543364273 hasConceptScore W1543364273C2775838275 @default.
• W1543364273 hasConceptScore W1543364273C2776151105 @default.
• W1543364273 hasConceptScore W1543364273C2777615887 @default.
• W1543364273 hasConceptScore W1543364273C2778979269 @default.
• W1543364273 hasConceptScore W1543364273C2779610285 @default.
• W1543364273 hasConceptScore W1543364273C2780795997 @default.
• W1543364273 hasConceptScore W1543364273C519581460 @default.
• W1543364273 hasConceptScore W1543364273C544778455 @default.
• W1543364273 hasConceptScore W1543364273C55493867 @default.
• W1543364273 hasConceptScore W1543364273C71924100 @default.
• W1543364273 hasIssue "6" @default.
• W1543364273 hasLocation W15433642731 @default.
• W1543364273 hasLocation W15433642732 @default.
• W1543364273 hasOpenAccess W1543364273 @default.
• W1543364273 hasPrimaryLocation W15433642731 @default.
• W1543364273 hasRelatedWork W1953847668 @default.
• W1543364273 hasRelatedWork W1978123724 @default.
• W1543364273 hasRelatedWork W2025687052 @default.
• W1543364273 hasRelatedWork W2070740797 @default.
• W1543364273 hasRelatedWork W2073260254 @default.
• W1543364273 hasRelatedWork W2074324989 @default.
• W1543364273 hasRelatedWork W2081917043 @default.
• W1543364273 hasRelatedWork W2091731575 @default.
• W1543364273 hasRelatedWork W2147934559 @default.

• next