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- W154344186 abstract "Research Article1 August 1984free access Actin-like sequences are present on human X and Y chromosomes. R. Heilig R. Heilig Search for more papers by this author A. Hanauer A. Hanauer Search for more papers by this author K.H. Grzeschik K.H. Grzeschik Search for more papers by this author M.C. Hors-Cayla M.C. Hors-Cayla Search for more papers by this author J.L. Mandel J.L. Mandel Search for more papers by this author R. Heilig R. Heilig Search for more papers by this author A. Hanauer A. Hanauer Search for more papers by this author K.H. Grzeschik K.H. Grzeschik Search for more papers by this author M.C. Hors-Cayla M.C. Hors-Cayla Search for more papers by this author J.L. Mandel J.L. Mandel Search for more papers by this author Author Information R. Heilig, A. Hanauer, K.H. Grzeschik, M.C. Hors-Cayla and J.L. Mandel The EMBO Journal (1984)3:1803-1807https://doi.org/10.1002/j.1460-2075.1984.tb02049.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The human genome contains greater than 20 actin-related sequences, six of which at least are expressed as protein. We have shown by blot hybridization the presence of actin-like sequences on both the X and the Y chromosomes. These sequences can be detected in HindIII digests of genomic DNA, using as probe cDNA clones corresponding to human alpha skeletal actin or to a hamster (beta or gamma) cytoskeletal actin; they show more homology to the latter probe. The actin probes also detect a polymorphic DNA fragment showing autosomal inheritance with a frequency for the major allele of 0.55 in the population studied. The X-linked actin sequence has been assigned to a centromeric region between Xp11 and Xq11 by hybridization to DNAs from a panel of human-mouse hybrid cell lines, and thus lies outside the postulated region of homology between the X and Y chromosomes. The Y-linked actin sequence can serve as a marker to analyse anomalies of sex determination or of gametogenesis in man. It was found in all XY males studied but was absent from the genomic DNA of four unrelated ‘XX male’ subjects and two XX hermaphrodites. This shows that the region of chromosome Y which contains the actin sequence is not translocated onto the X chromosome (or onto autosomes) in these patients. Previous ArticleNext Article Volume 3Issue 81 August 1984In this issue RelatedDetailsLoading ..." @default.
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- W154344186 title "Actin-like sequences are present on human X and Y chromosomes." @default.
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- W154344186 doi "https://doi.org/10.1002/j.1460-2075.1984.tb02049.x" @default.
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