FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543451657> ?p ?o ?g. }

• W1543451657 endingPage "171" @default.
• W1543451657 startingPage "170" @default.
• W1543451657 abstract "Top of pageAbstractThe need for new anti-cancer treatments is evident from the fact that malignant neoplasms are the second leading cause of death in the United States and third leading cause of death world-wide. Oncolytic adenovirus (Ad) vectors, which kill cancer cells by harnessing the cytolytic nature of the virus life cycle, are a new class of anti-cancer agents that have been demonstrated to be safe in humans but that have thus far yielded disappointing clinical efficacy results, despite demonstrating efficacy in pre-clinical models. We have constructed several new oncolytic Ad vectors that contain features designed to enhance vector efficacy while maintaining safety. All of our vectors over-express ADP, the viral protein required late in infection for efficient cell lysis and release of progeny virions at the culmination of the infectious cycle. Because our vectors over-express ADP, infected cells are lysed rapidly and progeny virions are released efficiently, which translates into improved cell-to-cell dissemination of the vector. Our vectors are also engineered to express the cancer therapeutic protein tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF family of cytokines that shows specificity for neoplastic cells. TRAIL expression and secretion provides a means of enhancing vector efficacy by providing a way to kill uninfected tumor cells. The TRAIL cDNA was inserted into our vectors such that it would be expressed similarly to ADP, that is, abundant expression late in the infectious cycle. We have shown in cultured cancer cells that our TRAIL-expressing vectors synthesize a large quantity of TRAIL late in the infection and are highly cytolytic to both infected and uninfected cells. TRAIL expression in infected cells leads to apoptosis in nearby uninfected cells and ADP expression results in efficient cytolysis of infected cells. As a safety feature, all of the vectors contain a deletion that eliminates expression of nearly all of the E3 proteins; these proteins function to protect infected cells from the immune system. As an additional safety feature, some vectors also contain deletions within the E1A gene that result in selective replication of the vector in cancer cells because the mutant E1A proteins are no longer able to bind to pRB family members or p300/CBP. The vectors were shown to reduce the growth of Hep3B liver cell tumor xenografts grown in nude mice." @default.
• W1543451657 created "2016-06-24" @default.
• W1543451657 creator A5004508225 @default.
• W1543451657 creator A5032387026 @default.
• W1543451657 creator A5069979824 @default.
• W1543451657 creator A5074721194 @default.
• W1543451657 creator A5075189401 @default.
• W1543451657 creator A5080845131 @default.
• W1543451657 creator A5081236075 @default.
• W1543451657 date "2004-05-01" @default.
• W1543451657 modified "2023-09-27" @default.
• W1543451657 title "Replication-competent oncolytic adenovirus vectors that express TRAIL and over-express ADP" @default.
• W1543451657 doi "https://doi.org/10.1016/j.ymthe.2004.06.385" @default.
• W1543451657 hasPublicationYear "2004" @default.
• W1543451657 type Work @default.
• W1543451657 sameAs 1543451657 @default.
• W1543451657 citedByCount "0" @default.
• W1543451657 crossrefType "journal-article" @default.
• W1543451657 hasAuthorship W1543451657A5004508225 @default.
• W1543451657 hasAuthorship W1543451657A5032387026 @default.
• W1543451657 hasAuthorship W1543451657A5069979824 @default.
• W1543451657 hasAuthorship W1543451657A5074721194 @default.
• W1543451657 hasAuthorship W1543451657A5075189401 @default.
• W1543451657 hasAuthorship W1543451657A5080845131 @default.
• W1543451657 hasAuthorship W1543451657A5081236075 @default.
• W1543451657 hasBestOaLocation W15434516571 @default.
• W1543451657 hasConcept C104317684 @default.
• W1543451657 hasConcept C12590798 @default.
• W1543451657 hasConcept C159047783 @default.
• W1543451657 hasConcept C2522874641 @default.
• W1543451657 hasConcept C2777283488 @default.
• W1543451657 hasConcept C40767141 @default.
• W1543451657 hasConcept C54355233 @default.
• W1543451657 hasConcept C70721500 @default.
• W1543451657 hasConcept C82210918 @default.
• W1543451657 hasConcept C86803240 @default.
• W1543451657 hasConcept C92087593 @default.
• W1543451657 hasConcept C95444343 @default.
• W1543451657 hasConceptScore W1543451657C104317684 @default.
• W1543451657 hasConceptScore W1543451657C12590798 @default.
• W1543451657 hasConceptScore W1543451657C159047783 @default.
• W1543451657 hasConceptScore W1543451657C2522874641 @default.
• W1543451657 hasConceptScore W1543451657C2777283488 @default.
• W1543451657 hasConceptScore W1543451657C40767141 @default.
• W1543451657 hasConceptScore W1543451657C54355233 @default.
• W1543451657 hasConceptScore W1543451657C70721500 @default.
• W1543451657 hasConceptScore W1543451657C82210918 @default.
• W1543451657 hasConceptScore W1543451657C86803240 @default.
• W1543451657 hasConceptScore W1543451657C92087593 @default.
• W1543451657 hasConceptScore W1543451657C95444343 @default.
• W1543451657 hasLocation W15434516571 @default.
• W1543451657 hasOpenAccess W1543451657 @default.
• W1543451657 hasPrimaryLocation W15434516571 @default.
• W1543451657 hasRelatedWork W17101588 @default.
• W1543451657 hasRelatedWork W1994217611 @default.
• W1543451657 hasRelatedWork W2026719326 @default.
• W1543451657 hasRelatedWork W2079316258 @default.
• W1543451657 hasRelatedWork W2079317833 @default.
• W1543451657 hasRelatedWork W2331318261 @default.
• W1543451657 hasRelatedWork W2333571229 @default.
• W1543451657 hasRelatedWork W4238535787 @default.
• W1543451657 hasRelatedWork W4248136714 @default.
• W1543451657 hasRelatedWork W4252139816 @default.
• W1543451657 hasVolume "9" @default.
• W1543451657 isParatext "false" @default.
• W1543451657 isRetracted "false" @default.
• W1543451657 magId "1543451657" @default.
• W1543451657 workType "article" @default.