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- W1543460695 abstract "Publisher Summary This chapter discusses a study to examine the cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Six normal infants were studied. They were born at 28–40 weeks of gestation and NMR spectra were obtained when they were 16 h to 97 days old: their gestational-equivalent age at this time was 38–42 weeks. Unilateral lesions were detected by ultrasound in four infants born at 34–40 weeks of gestation and aged 1–14 days. In three of them the diagnosis was thought to be early cerebral infarction, and in the fourth, a small hemorrhage into a possibly infarcted area. PCr/Pi was always reduced in the affected hemisphere compared with the normal one. Depletion was far worse than encountered in any of the birth asphyxiated babies, and was accompanied by a profound intracellular acidosis. The infants subsequently died but there was no reason to suppose that the oxygen supply to the brain was seriously inadequate at the time when the studies were done. The metabolic abnormalities in both these illnesses inhibit the tricarboxylic acid cycle. The most likely explanation for the extremely severe disruption of energy status is that insufficient substrate was available for oxidative phosphorylation to occur." @default.
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- W1543460695 date "1986-01-01" @default.
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- W1543460695 title "Cerebral metabolism in newborn infants studied by phosphorus nuclear magnetic resonance spectroscopy" @default.
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- W1543460695 doi "https://doi.org/10.1016/b978-0-407-00451-1.50058-8" @default.
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