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- W1543500603 abstract "The Antarctic fish Pagothenia bernacchii has one major haemoglobin, Hbl (over 95% of the total blood content). Hbl has a strong alkaline Bohr effect and at low pH exhibits the reduced ligand affinity and co-operativity that comprise the Root effect. We have determined the complete amino acid sequence of P. bernacchii Hbl and also the structure of its carbonmonoxy derivative by X-ray crystallography, to a resolution of 2·5 Å. The crystallographic R-factor of the refined structure is 18%. The three-dimensional structure of this fish haemoglobin is similar to that of human haemoglobin A, with a root-mean-square difference in main-chain atom positions of 1.4 Å after superimposition of the two structures, despite only 48 % homology of their amino acid sequences (including insertion of a single residue in the CD region of the fish α-chain). Large structural differences occur only at the N and C termini of both the α- and β-chains. Neither these nor other smaller structural differences provide any obvious explanation of the Root effect of this or other fish haemoglobins." @default.
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- W1543500603 date "1992-03-01" @default.
- W1543500603 modified "2023-10-17" @default.
- W1543500603 title "Haemoglobin of the Antarctic fish Pagothenia bernacchii" @default.
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- W1543500603 doi "https://doi.org/10.1016/0022-2836(92)91007-c" @default.
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