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- W1543622415 abstract "Functional renal failure is a common complication of advanced cirrhosis with ascites, to be distinguished from organic renal diseases that are now increasingly seen in patients with cirrhosis. The basis for the development of functional renal failure is systemic arterial vasodilatation with paradoxical renal vasoconstriction. Cardiac dysfunction and altered renal autoregulation also contribute to the pathogenesis. There are recent efforts to lower the cutoff value for diagnosing functional renal failure, so as to encourage early application of treatment. Clinical presentations can range from volume-responsive prerenal failure to potentially fatal hepatorenal syndrome. The mainstay of treatment includes the removal of precipitating factors, intravascular volume replacement, vasoconstrictor therapy, insertion of a transjugular intrahepatic portosystemic stent shunt, or liver transplantation. Liver transplantation remains the treatment of choice for hepatorenal syndrome as it corrects many of the pathophysiologic abnormalities associated with this condition. Patient outcome is improved further if renal function is normalized before liver transplantation." @default.
- W1543622415 created "2016-06-24" @default.
- W1543622415 creator A5064394293 @default.
- W1543622415 date "2011-10-31" @default.
- W1543622415 modified "2023-09-27" @default.
- W1543622415 title "Renal Complications of Liver Disease and the Hepatorenal Syndrome" @default.
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- W1543622415 doi "https://doi.org/10.1002/9781119950509.ch15" @default.
- W1543622415 hasPublicationYear "2011" @default.
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