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- W1543665257 abstract "Embryonic stem (ES) cells are isolated from the inner cell mass (ICM) of a blastocyst stage embryo, which consists of a layer of trophoblast cells lining the ICM and blastocoel or blastocyst cavity. The ICM and trophoblast cells give rise to the embryo proper and extraembryonic tissue, respectively. Thirthy years ago the in vitro culture of mouse ES (mES) cells was first described (Evans and Kaufman, 1981; Martin, 1981) and later in 1998 also human ES (hES) cells were derived (Thomson et al. 1998). ES cells are characterized by the unique properties of unlimited self-renewal without senescence and pluripotency. The latter infers that ES cells give rise to all cell types of the body. These specific properties led to the great scientific interest in ES cell either for their potential medical applications or as models to address more fundamental questions in development." @default.
- W1543665257 created "2016-06-24" @default.
- W1543665257 creator A5029807963 @default.
- W1543665257 creator A5046259279 @default.
- W1543665257 date "2012-04-20" @default.
- W1543665257 modified "2023-09-25" @default.
- W1543665257 title "Genomic Integrity of Mouse Embryonic Stem Cells" @default.
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- W1543665257 doi "https://doi.org/10.5772/37327" @default.
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