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• W1543669829 abstract "The effect of valproic acid on the distribution of gavaged 65Zn in maternal and embryonic tissue of Sprague-Dawley rats was examined 24 h after gavaging of the drug on d 13 of pregnancy. Valproic acid treatment resulted in a significantly higher retention of 65Zn in maternal liver and lower amounts in uterus, placenta and embryos than in controls. Compared to controls, gel chromatography of maternal liver from valproic acid-treated dams showed higher 65Zn counts associated with a protein peak of molecular weight of 6,500, the approximate molecular weight of the Zn-binding protein metallothionein. These results support the idea that the teratogenicity of valproic acid is in part due to an induction of embryonic Zn deficiency secondary to a drug-induced sequestering of Zn into maternal liver that results in a decrease in maternal plasma Zn and subsequent reduction in embryonic Zn uptake." @default.
• W1543669829 created "2016-06-24" @default.
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• W1543669829 date "1989-04-01" @default.
• W1543669829 modified "2023-10-04" @default.
• W1543669829 title "The Effect of Valproic Acid on 65Zn Distribution in the Pregnant Rat" @default.
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• W1543669829 doi "https://doi.org/10.1093/jn/119.4.607" @default.
• W1543669829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2495343" @default.
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