Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543695514> ?p ?o ?g. }
- W1543695514 endingPage "1113" @default.
- W1543695514 startingPage "1107" @default.
- W1543695514 abstract "Urinary tract infections (UTIs), which are mainly due to uropathogenic Escherichia coli (UPEC), occur via the retrograde ascent of the bacteria along the urinary tract system. The adhesion and invasion mechanisms of UPEC have been extensively studied in bladder epithelial cells, but less is known about the role of renal tubule epithelial cells (RTEC) in renal antibacterial defences. This review considers recent advances in the understanding of the role of RTECs in inducing an innate immune response mediated by Toll-like receptors (TLRs) in experimental UTI. Collecting duct cells are a preferential site of adhesion of UPEC colonizing the kidneys. Epithelial TLR4 activation induces an inflammatory response and the recruitment of lipid rafts to the plasma membrane, both of which facilitate the transcytosis of non-cytolytic UPEC strains across intact collecting duct cell layers to invade the renal interstitium. Arginine vasopressin, which regulates water absorption in the collecting duct, also acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by UPEC. The role of epithelial TLR5 in renal host defences is also discussed. These findings highlight the role of RTECs in triggering the innate immune response in the context of ascending UTIs." @default.
- W1543695514 created "2016-06-24" @default.
- W1543695514 creator A5001718959 @default.
- W1543695514 creator A5017473486 @default.
- W1543695514 creator A5023281192 @default.
- W1543695514 creator A5089949394 @default.
- W1543695514 date "2011-05-25" @default.
- W1543695514 modified "2023-09-25" @default.
- W1543695514 title "A role for collecting duct epithelial cells in renal antibacterial defences" @default.
- W1543695514 cites W135825401 @default.
- W1543695514 cites W1502075862 @default.
- W1543695514 cites W1511030747 @default.
- W1543695514 cites W1582409628 @default.
- W1543695514 cites W1585991998 @default.
- W1543695514 cites W1603155783 @default.
- W1543695514 cites W1666110846 @default.
- W1543695514 cites W1940749453 @default.
- W1543695514 cites W1970012260 @default.
- W1543695514 cites W1971696954 @default.
- W1543695514 cites W1974404363 @default.
- W1543695514 cites W1977378846 @default.
- W1543695514 cites W1977466269 @default.
- W1543695514 cites W1980273234 @default.
- W1543695514 cites W1988456469 @default.
- W1543695514 cites W1990731735 @default.
- W1543695514 cites W1991987254 @default.
- W1543695514 cites W1999823179 @default.
- W1543695514 cites W2004465286 @default.
- W1543695514 cites W2005843299 @default.
- W1543695514 cites W2007908049 @default.
- W1543695514 cites W2009168326 @default.
- W1543695514 cites W2009651486 @default.
- W1543695514 cites W2030605887 @default.
- W1543695514 cites W2036083275 @default.
- W1543695514 cites W2036428031 @default.
- W1543695514 cites W2039110498 @default.
- W1543695514 cites W2039418057 @default.
- W1543695514 cites W2043633262 @default.
- W1543695514 cites W2044539436 @default.
- W1543695514 cites W2046721427 @default.
- W1543695514 cites W2053191479 @default.
- W1543695514 cites W2054800529 @default.
- W1543695514 cites W2055128358 @default.
- W1543695514 cites W2062431830 @default.
- W1543695514 cites W2072442344 @default.
- W1543695514 cites W2085418238 @default.
- W1543695514 cites W2087369502 @default.
- W1543695514 cites W2089877898 @default.
- W1543695514 cites W2095891588 @default.
- W1543695514 cites W2096770031 @default.
- W1543695514 cites W2109359144 @default.
- W1543695514 cites W2120046045 @default.
- W1543695514 cites W2126149196 @default.
- W1543695514 cites W2140433991 @default.
- W1543695514 cites W2143033651 @default.
- W1543695514 cites W2160707283 @default.
- W1543695514 cites W2165642163 @default.
- W1543695514 cites W2172286252 @default.
- W1543695514 doi "https://doi.org/10.1111/j.1462-5822.2011.01614.x" @default.
- W1543695514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21615666" @default.
- W1543695514 hasPublicationYear "2011" @default.
- W1543695514 type Work @default.
- W1543695514 sameAs 1543695514 @default.
- W1543695514 citedByCount "29" @default.
- W1543695514 countsByYear W15436955142012 @default.
- W1543695514 countsByYear W15436955142013 @default.
- W1543695514 countsByYear W15436955142014 @default.
- W1543695514 countsByYear W15436955142015 @default.
- W1543695514 countsByYear W15436955142016 @default.
- W1543695514 countsByYear W15436955142017 @default.
- W1543695514 countsByYear W15436955142018 @default.
- W1543695514 countsByYear W15436955142019 @default.
- W1543695514 countsByYear W15436955142021 @default.
- W1543695514 countsByYear W15436955142022 @default.
- W1543695514 countsByYear W15436955142023 @default.
- W1543695514 crossrefType "journal-article" @default.
- W1543695514 hasAuthorship W1543695514A5001718959 @default.
- W1543695514 hasAuthorship W1543695514A5017473486 @default.
- W1543695514 hasAuthorship W1543695514A5023281192 @default.
- W1543695514 hasAuthorship W1543695514A5089949394 @default.
- W1543695514 hasConcept C105702510 @default.
- W1543695514 hasConcept C134018914 @default.
- W1543695514 hasConcept C136449434 @default.
- W1543695514 hasConcept C203014093 @default.
- W1543695514 hasConcept C2780091579 @default.
- W1543695514 hasConcept C2781212128 @default.
- W1543695514 hasConcept C86803240 @default.
- W1543695514 hasConcept C8891405 @default.
- W1543695514 hasConcept C89423630 @default.
- W1543695514 hasConcept C95444343 @default.
- W1543695514 hasConceptScore W1543695514C105702510 @default.
- W1543695514 hasConceptScore W1543695514C134018914 @default.
- W1543695514 hasConceptScore W1543695514C136449434 @default.
- W1543695514 hasConceptScore W1543695514C203014093 @default.
- W1543695514 hasConceptScore W1543695514C2780091579 @default.
- W1543695514 hasConceptScore W1543695514C2781212128 @default.
- W1543695514 hasConceptScore W1543695514C86803240 @default.
- W1543695514 hasConceptScore W1543695514C8891405 @default.