Matches in SemOpenAlex for { <https://semopenalex.org/work/W1543829478> ?p ?o ?g. }
- W1543829478 endingPage "454" @default.
- W1543829478 startingPage "449" @default.
- W1543829478 abstract "Exome sequencings were conducted using 59 patients having rheumatoid arthritis (RA) and 93 controls. After stepwise filtering, 107 genes showed less than 0.05 of P-values by gene-burden tests. Among 107 genes, NDUFA7 which is a subunit of the complex I in the mitochondrial respiratory chain was selected for further analysis based on previous reports. A case–control study was performed on the three single-nucleotide variants (SNVs) of NDUFA7 with 432 cases and 432 controls. An association was observed between NDUFA7 and RA with severe erosive arthritis. These results together with previous reports suggested the involvement of reactive oxygen species (ROS) in the pathogenesis of RA. In the next step, four SNVs from three genes related to the mitochondrial respiratory chain were selected, which is a major source of ROS, and conducted a case–control study. An association was observed based on a pathway-burden test comprising NDUFA7, SDHAF2, SCO1 and ATP5O: P=1.56E-04, odds ratio=2.16, 95% confidence interval=1.43–3.28. Previous reports suggested the involvement of ROS in the pathogenesis of RA. The aggregation of SNVs in the mitochondria respiratory chain suggests the pivotal role of those SNVs in the pathogenesis of RA with severe erosive arthritis." @default.
- W1543829478 created "2016-06-24" @default.
- W1543829478 creator A5005631158 @default.
- W1543829478 creator A5010644445 @default.
- W1543829478 creator A5039165431 @default.
- W1543829478 creator A5040888877 @default.
- W1543829478 creator A5044520086 @default.
- W1543829478 creator A5048157255 @default.
- W1543829478 creator A5052702717 @default.
- W1543829478 creator A5056822373 @default.
- W1543829478 creator A5065226364 @default.
- W1543829478 creator A5066182280 @default.
- W1543829478 creator A5075788011 @default.
- W1543829478 creator A5076319786 @default.
- W1543829478 creator A5079189006 @default.
- W1543829478 date "2015-05-28" @default.
- W1543829478 modified "2023-10-12" @default.
- W1543829478 title "Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients" @default.
- W1543829478 cites W1513024220 @default.
- W1543829478 cites W1970037245 @default.
- W1543829478 cites W1971102564 @default.
- W1543829478 cites W1971978135 @default.
- W1543829478 cites W1973687895 @default.
- W1543829478 cites W1973878786 @default.
- W1543829478 cites W1977895192 @default.
- W1543829478 cites W1984068087 @default.
- W1543829478 cites W1985213494 @default.
- W1543829478 cites W1986680425 @default.
- W1543829478 cites W1989590412 @default.
- W1543829478 cites W1989763054 @default.
- W1543829478 cites W2013573826 @default.
- W1543829478 cites W2028612636 @default.
- W1543829478 cites W2030578737 @default.
- W1543829478 cites W2036210716 @default.
- W1543829478 cites W2041076416 @default.
- W1543829478 cites W2045790063 @default.
- W1543829478 cites W2051172646 @default.
- W1543829478 cites W2056171616 @default.
- W1543829478 cites W2063655230 @default.
- W1543829478 cites W2065386692 @default.
- W1543829478 cites W2075874339 @default.
- W1543829478 cites W2079100436 @default.
- W1543829478 cites W2090096683 @default.
- W1543829478 cites W2091583677 @default.
- W1543829478 cites W2093120748 @default.
- W1543829478 cites W2095158157 @default.
- W1543829478 cites W2099248872 @default.
- W1543829478 cites W2103441770 @default.
- W1543829478 cites W2108234281 @default.
- W1543829478 cites W2110826367 @default.
- W1543829478 cites W2112113834 @default.
- W1543829478 cites W2119180969 @default.
- W1543829478 cites W2121966499 @default.
- W1543829478 cites W2126105762 @default.
- W1543829478 cites W2143992683 @default.
- W1543829478 cites W2146634870 @default.
- W1543829478 cites W2147914485 @default.
- W1543829478 cites W2152348310 @default.
- W1543829478 cites W2163652380 @default.
- W1543829478 cites W2168133698 @default.
- W1543829478 cites W2416322894 @default.
- W1543829478 doi "https://doi.org/10.1038/jhg.2015.50" @default.
- W1543829478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26016412" @default.
- W1543829478 hasPublicationYear "2015" @default.
- W1543829478 type Work @default.
- W1543829478 sameAs 1543829478 @default.
- W1543829478 citedByCount "17" @default.
- W1543829478 countsByYear W15438294782017 @default.
- W1543829478 countsByYear W15438294782018 @default.
- W1543829478 countsByYear W15438294782019 @default.
- W1543829478 countsByYear W15438294782020 @default.
- W1543829478 countsByYear W15438294782021 @default.
- W1543829478 countsByYear W15438294782022 @default.
- W1543829478 crossrefType "journal-article" @default.
- W1543829478 hasAuthorship W1543829478A5005631158 @default.
- W1543829478 hasAuthorship W1543829478A5010644445 @default.
- W1543829478 hasAuthorship W1543829478A5039165431 @default.
- W1543829478 hasAuthorship W1543829478A5040888877 @default.
- W1543829478 hasAuthorship W1543829478A5044520086 @default.
- W1543829478 hasAuthorship W1543829478A5048157255 @default.
- W1543829478 hasAuthorship W1543829478A5052702717 @default.
- W1543829478 hasAuthorship W1543829478A5056822373 @default.
- W1543829478 hasAuthorship W1543829478A5065226364 @default.
- W1543829478 hasAuthorship W1543829478A5066182280 @default.
- W1543829478 hasAuthorship W1543829478A5075788011 @default.
- W1543829478 hasAuthorship W1543829478A5076319786 @default.
- W1543829478 hasAuthorship W1543829478A5079189006 @default.
- W1543829478 hasBestOaLocation W15438294781 @default.
- W1543829478 hasConcept C104317684 @default.
- W1543829478 hasConcept C126322002 @default.
- W1543829478 hasConcept C135763542 @default.
- W1543829478 hasConcept C146304588 @default.
- W1543829478 hasConcept C153209595 @default.
- W1543829478 hasConcept C156957248 @default.
- W1543829478 hasConcept C24586158 @default.
- W1543829478 hasConcept C2777077863 @default.
- W1543829478 hasConcept C2777575956 @default.
- W1543829478 hasConcept C2780942790 @default.