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• W1543871129 endingPage "763" @default.
• W1543871129 startingPage "741" @default.
• W1543871129 abstract "Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ is being challenged by new evidence for an essential function of Aβ at the synapse. Aβ protein exists in different assembly states in the central nervous system and plays distinct roles ranging from synapse and memory formation to memory loss and neuronal cell death. Aβ is present in the brain of symptom-free people where it likely performs important physiological roles. New evidence indicates that synaptic activity directly evokes the release of Aβ at the synapse. At physiological levels, Aβ is a normal, soluble product of neuronal metabolism that regulates synaptic function beginning early in life. Monomeric Aβ40 and Aβ42 are the predominant forms required for synaptic plasticity and neuronal survival. With age, some assemblies of Aβ are associated with synaptic failure and Alzheimer's disease pathology, possibly targeting the N-methyl-D-aspartic acid receptor through the nicotinic acetylcholine receptor, mitochondrial Aβ alcohol dehydrogenase, and cyclophilin D. But emerging data suggests a distinction between age effects on the target response in contrast to the assembly state or the accumulation of the peptide. Both aging and Aβ independently decrease neuronal plasticity. Our laboratory has reported that Aβ, glutamate, and lactic acid are each increasingly toxic with neuron age. The basis of the age-related toxicity partly resides in age-related mitochondrial dysfunction and an oxidative shift in mitochondrial and cytoplasmic redox potential. In turn, signaling through phosphorylated extracellular signal-regulated protein kinases is affected along with an age-independent increase in phosphorylated cAMP response element-binding protein. This review examines the long-awaited functional impact of Aβ on synaptic plasticity." @default.
• W1543871129 created "2016-06-24" @default.
• W1543871129 creator A5011704834 @default.
• W1543871129 creator A5025475085 @default.
• W1543871129 date "2010-11-25" @default.
• W1543871129 modified "2023-10-13" @default.
• W1543871129 title "Amyloid-β as a Modulator of Synaptic Plasticity" @default.
• W1543871129 cites W1511457910 @default.
• W1543871129 cites W1514559719 @default.
• W1543871129 cites W152142312 @default.
• W1543871129 cites W1523103679 @default.
• W1543871129 cites W1533021419 @default.
• W1543871129 cites W1536538075 @default.
• W1543871129 cites W1566737177 @default.
• W1543871129 cites W1567624342 @default.
• W1543871129 cites W1569248335 @default.
• W1543871129 cites W1570789308 @default.
• W1543871129 cites W1572640432 @default.
• W1543871129 cites W1573292604 @default.
• W1543871129 cites W1585306115 @default.
• W1543871129 cites W1597908762 @default.
• W1543871129 cites W1605971438 @default.
• W1543871129 cites W1631718287 @default.
• W1543871129 cites W1677883125 @default.
• W1543871129 cites W1857293157 @default.
• W1543871129 cites W1890393292 @default.
• W1543871129 cites W1900806927 @default.
• W1543871129 cites W1909502264 @default.
• W1543871129 cites W1929267935 @default.
• W1543871129 cites W1932612562 @default.
• W1543871129 cites W1955491145 @default.
• W1543871129 cites W1963627192 @default.
• W1543871129 cites W1963885312 @default.
• W1543871129 cites W1964049915 @default.
• W1543871129 cites W1964371958 @default.
• W1543871129 cites W1965050626 @default.
• W1543871129 cites W1965505012 @default.
• W1543871129 cites W1965516341 @default.
• W1543871129 cites W1967917932 @default.
• W1543871129 cites W1968032657 @default.
• W1543871129 cites W1968129825 @default.
• W1543871129 cites W1968257316 @default.
• W1543871129 cites W1969853133 @default.
• W1543871129 cites W1969906096 @default.
• W1543871129 cites W1970164987 @default.
• W1543871129 cites W1971566977 @default.
• W1543871129 cites W1972995966 @default.
• W1543871129 cites W1974179395 @default.
• W1543871129 cites W1975775468 @default.
• W1543871129 cites W1976678585 @default.
• W1543871129 cites W1977390447 @default.
• W1543871129 cites W1977892449 @default.
• W1543871129 cites W1978106990 @default.
• W1543871129 cites W1979543098 @default.
• W1543871129 cites W1979586675 @default.
• W1543871129 cites W1980750700 @default.
• W1543871129 cites W1980825524 @default.
• W1543871129 cites W1981458288 @default.
• W1543871129 cites W1983600166 @default.
• W1543871129 cites W1984924722 @default.
• W1543871129 cites W1986900475 @default.
• W1543871129 cites W1987888225 @default.
• W1543871129 cites W1988731658 @default.
• W1543871129 cites W1988772292 @default.
• W1543871129 cites W1990752558 @default.
• W1543871129 cites W1991988242 @default.
• W1543871129 cites W1992191171 @default.
• W1543871129 cites W1992476409 @default.
• W1543871129 cites W1992500403 @default.
• W1543871129 cites W1993158184 @default.
• W1543871129 cites W1993465897 @default.
• W1543871129 cites W1995580860 @default.
• W1543871129 cites W1996603253 @default.
• W1543871129 cites W1997411557 @default.
• W1543871129 cites W1998553787 @default.
• W1543871129 cites W2000303677 @default.
• W1543871129 cites W2002217566 @default.
• W1543871129 cites W2002984652 @default.
• W1543871129 cites W2003729768 @default.
• W1543871129 cites W2004343753 @default.
• W1543871129 cites W2005320724 @default.
• W1543871129 cites W2006214613 @default.
• W1543871129 cites W2006472192 @default.
• W1543871129 cites W2006675359 @default.
• W1543871129 cites W2006718453 @default.
• W1543871129 cites W2007047564 @default.
• W1543871129 cites W2007239691 @default.
• W1543871129 cites W2009320319 @default.
• W1543871129 cites W2013823660 @default.
• W1543871129 cites W2014033528 @default.
• W1543871129 cites W2014739744 @default.
• W1543871129 cites W2014764883 @default.
• W1543871129 cites W2015588918 @default.
• W1543871129 cites W2016425872 @default.
• W1543871129 cites W2016811754 @default.
• W1543871129 cites W2017239646 @default.
• W1543871129 cites W2017492709 @default.
• W1543871129 cites W2018885303 @default.

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